Conserved Protein Domain Family
ChaP_like

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cd08351: ChaP_like 
ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha), and similar proteins
ChaP is an enzyme involved in the biosynthesis of the potent antitumor agent chartreusin (cha). Cha is an aromatic polyketide glycoside produced by Streptomyces chartreusis. ChaP may play a role as a meta-cleavage dioxygenase in the oxidative rearrangement of the anthracyclic polyketide. ChaP belongs to a conserved domain superfamily that is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases.
Statistics
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PSSM-Id: 319939
View PSSM: cd08351
Aligned: 61 rows
Threshold Bit Score: 139.179
Threshold Setting Gi: 925572054
Created: 12-Nov-2009
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
metal binding
Feature 1: metal binding site [ion binding site], 3 residue positions
Conserved feature residue pattern:H H EClick to see conserved feature residue pattern help
Evidence:
  • Comment:predicted based on homologous proteins with known structure.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1            #                                                              #            
gi 68146483    3 VELNHTIVLVKDKDASATFMADL--LGLPKPkeMGPFAVLQLAND-VSIDFMDfr----gEGDIVPGHCAFLISDEEFDQ 75
gi 654476457   3 ITLNHTIVPARDKQASATFLAKL--LGLHVGepFGPFVPVRVGET-LTLDFADadfadrgVTTIAPHHYAFQVDDAEFDE 79
gi 702801254   3 VELNHTIVPARDPQASAQFLADI--LGLSVDppLAHFTPVTLANQ-VSLDYDQ-------LDDFEPHHYAFMVSEEEFDA 72
gi 917196430   3 VELNHTIVPVHDKEEGAAFLTAI--LGLEPPqhVGPFVCVRTSNG-VCLDYDD-------RWEVVSHHYCFLVSDDAFDA 72
gi 522159599   3 VQLNHTIVPATDKHASAEFLAGI--LGLEVGa-HDFFVPIELDHG-VLLDFMD-------AENFGWQHYAFLVSEAEFDA 71
gi 499921057   3 VVLNHTIVPVADKERSARLLAAL--LGVEAGepAGPFVPVRVNDE-LTLDFDD-------RLGARPGHYAFLVDDVTFDV 72
gi 407311715  17 IVLNHTIVPAADRHAAATFFADL--LGLAVGgqIGPFAPVRVNDD-LTLDFDD-------RVTVVPGHYGFLVDADTFDA 86
gi 925572054  22 ISLNHTIVLTKDKWAAAKFLADM--VESEATa-FGPFVRVHTGETdIEFQNIEdn---vaNDHIPTTHLAFLMSEGELDI 95
gi 656083527   3 IVLDHTIAPATNSRSAATFFAELmgLEVSPP--SGPFLPVSINES-LTFDFDE-------RGQIAPAHFGFLVDDDTFQA 72
gi 522126861   3 VELNHTIVCVTDREKSAEFLAAI--LGLRTGpvTGPFVPIALANG-VTLDYLR-------VDHVTSQHYAFLVGDEDFDA 72
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
Feature 1                                                             #   
gi 68146483   76 IFGRIREGG-------IEHWADQyhre---pgrINDRDGGRGVYFEDPSGHNMEIMT 122
gi 654476457  80 IFERIVAAG-------LNYYAEPheph--rygeINTWRGGRAVYFDDPNGHIMEVLT 127
gi 702801254  73 AFARIQDGG-------ITHYADPacqengqiyrSERTEGCRGTYFRDPDGHLMEILT 122
gi 917196430  73 AFARIVAAD-------LAYNGAPngsl--pgeiYHSKTGGRGVYFSDPDGHLMELLT 120
gi 522159599  72 AFARITAAG-------ARYYGTPdkaa---mgeIYFHNGGRGVYFEDPDGHAMELLT 118
gi 499921057  73 ALDQARRSG-------LAWGSAPrtv----drqINHLGGGRGVYIRDPDGIAYEFFT 118
gi 407311715  87 LLRRLARQPevdfgsgVEHGWDRa---------INQLAGGRGVYVRAPDGHSYEFFT 134
gi 925572054  96 VLEKLKRHG-------VQPYQDMfyde---pgvNNLYGGRGCYIHDPVDGHQWEFIT 142
gi 656083527  73 MLDRLATLPa------IEFGSGPehgw---drqTSAIGGGRGVYVRDPDNGHTYELF 120
gi 522126861  73 ALARIRAAG-------ITFWADPfhdr---pgeVGTVNGSRGIYFADPDGHNMELLT 119

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