1SS4


Conserved Protein Domain Family
VOC_like

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cd08353: VOC_like 
Click on image for an interactive view with Cn3D
uncharacterized subfamily of vicinal oxygen chelate (VOC) family
The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.
Statistics
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PSSM-Id: 319941
View PSSM: cd08353
Aligned: 36 rows
Threshold Bit Score: 192.02
Threshold Setting Gi: 758930031
Created: 29-Oct-2009
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
putative dimer
Conserved site includes 56 residues -Click on image for an interactive view with Cn3D
Feature 1:putative dimer interface [polypeptide binding site]
Evidence:
  • Structure:1SS4; Bacillus cereus glyoxalase family protein Apc24694 dimer, contacts at 4A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ############           ###           #  ### #            ## ## ##   #  ##       
1SS4_A         9 LLRXDNVSIVVESLDNAISFFEEIGLNLEGRANVEGEWAGRVTGLGSQCVEIAXXVTPDGHSRIELSRFLTPPtiadhrt 88
gi 739646782   1 MLRFEHVGVVVDDLDAVGAFFLDLGFESDGRMHVDGEVVDRINGLDGVRAELMMVRTPDRTCTLELVKYHAPAsgetpqp 80
gi 916968755   3 LNKMDHVGIIVEDLESVKAFFSTLGLELIGEQNINGEWIGNIYGVDALEASIAMMKVPHDETAIELIQFRDQSsttnksi 82
gi 857573821   3 INRIDHVGVIVNDLSAAKAFFLDFGLEVQGEGEVEGEWVDRVVGLNNVKGKCVVLQPTDGQANIELFKFYTPSdeqdiqk 82
gi 504715193   3 IKRIDHVSVNVNDLSAAKAFFLDLGLEVQGEWEMEGEWLGQVVGLTDVKTACVGLRTPDGQAWIELVKFHTPSdeqdflk 82
gi 910080822   3 TLRFDHVGVVVDDLDAVAAFFLDLGFEREGGMVVEGEWVDKINGLDGVRAEVVMVRVPDSSGKLELVKYHTPAdsegahp 82
gi 947454458   3 VRSLEHIGIIVRDLDTVADFFELLGFECGERAVVGGEWADRVNGLAGTEVEMVFVTAPDGSGAIELSRMISPAsveepav 82
gi 663597107   4 VRRLDHIGVVVEDLDAATEFFLGLGLEKAGAMSMRGDWIGGIIGLEDVHTDVVFVSAPDGTGKLELIKFHSPAddrgvre 83
gi 521978649   4 VRRFDHVGVTVADLDAATAFFVGLGLEIEGRTSVEGHFIDTVIGIPDSRTEIVMLRTPGGGSSVELSSFVRPDplpglpa 83
gi 916717331   8 VTNFVHIGLVVEDLDETVRFLALLGFDCGEPGVFSGEWIDRIIGLRDARVEIVMARAPDGSDMFEVVRFHSPSaraqepa 87
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
Feature 1           ##############  ##  #        #   # #     ###      ###    # 
1SS4_A        89 apvNALGYLRVXFTVEDIDEXVSRLTKHGAELVgeVVQYENSYRLCYIRGVEGILIGLAEEL 150
gi 739646782  81 apsNRLGLRHLLFEVDDLDRIVDGMREKGFDTVgeVQDYGTSWRLCYLRGPEGLIIELAQKL 142
gi 916968755  83 hfpRNVGASHFAFSVQNIEQVVEQLATTSSQVIgeITQFEDIYKLCYIKGPEGIYIELAEKL 144
gi 857573821  83 pfaNTLGIRHIAFAVEDIEAVVAKLKKKGTEIFseIQQYEDSYKLCYVRGPEGIILELAEEI 144
gi 504715193  83 plaNTLGIRHIAFAVEDIEAVVAKLKTKGTEIFseIHQYEESYKLCYVRGPEGIILELAEEI 144
gi 910080822  83 lpaNQLGFRHIAIEINDLNAIVDELRDNGFDTVgeVRDFEDAYRLCYVRGPEGLIIELTEQI 144
gi 947454458  83 lpaDALGLRHLAYRVDGLEPLLKRVRAAGYGLVgeVVNYEDVWLVCYVRGPEGIIVELGERL 144
gi 663597107  84 aaaNRLGIRHLAFVVEDLDGVLGALAAKGATRIgkIHDHEGVVRLCYVRGPEGIIVELAEEI 145
gi 521978649  84 aaaNELGLRSLGFEVDDVDAAVDWAAGQGFGLVggIGEYEGVWRMAYVRGPEGIIVALAERI 145
gi 916717331  88 paaNRPGLRHIAFTVDDVRGVVDRVREAGWETVgeIVDFENTFLLCYVRGPEGLIVELAERL 149

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