3R4Q


Conserved Protein Domain Family
VOC_like

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cd08354: VOC_like 
Click on image for an interactive view with Cn3D
uncharacterized subfamily of vicinal oxygen chelate (VOC) family
The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.
Statistics
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PSSM-Id: 319942
View PSSM: cd08354
Aligned: 8 rows
Threshold Bit Score: 177.943
Threshold Setting Gi: 15807201
Created: 30-Oct-2009
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
putative metalhomodimer
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1: putative metal binding site [ion binding site], 3 residue positions
Conserved feature residue pattern:E H EClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on homologous proteins in the same superfamily

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          #                                                                             
3R4Q_A         9 IMETALYADDLDAAEAFYRdVFGLEMVLklPGQLVFFKCGR-QMLLLFDpqessradan--------------------- 66
gi 21229670    1 MLETGVYVADLDRACAFYAqVLGLQPMHr-DARMAAYAIAPaQVLLLFLqgsttttvrlp-------------------g 60
gi 15807201    3 ALETCLYADDLSAAEAFYSgVLGLTLHSkvAGRHLFYRLDG-SMLLIFNpeasakpg----------------------- 58
gi 55981524    3 VLETSVYAEDLEKARAFYEgVLGLPCFQfkPPRHAFFRAGR-GVFLVFNpkltaket----------------------- 58
gi 83814326    8 ALETSLYADDLAAAEQFYGdVLGLDVMLrtEGNHITFRCGP-GVVHVFDpaasrdrt----------------------- 63
gi 222439003  15 ILETAVYVDDMDAAHGFYEgILGLKRMVa-GDRLFAYDAGPaQTLLVFYrghtgedvptp-------------------g 74
gi 198258366   6 IFETILYAEDLPAAKLFYRdTLGLELMRe-SELVLVFRLQD-SVLLVFDprkssppgr---------------------- 61
gi 67901840   13 VLETCLYVRDIHASRKFYEdVLNIKPFMq-SHRSACFSLGN-TTLLLFQlgqtdadittpsgvipghgpsaqivaklnaa 90
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
Feature 1                    #                                                #    
3R4Q_A        67 npiprhgavGQGHFCFYADDkAEVDEWKTRFEALEiPVEHyhrwpnGSYSVYIRDPAGNSVEVGEG 132
gi 21229670   61 gtipphdghGHTHYALAIAT-ESLAAWEAHLHACDvAIEGrtqwpgGGQSMYFRDPDDHLVELATP 125
gi 15807201   59 -dvpshqgkPGGHACLAIPR-EQTAEWETRLRGHGlDVTRyaw-geRGESLYFDDPAGNVLELAPA 121
gi 55981524   59 -hlpphgakGSVHVAFRVEE-EELPAWEARLKAAGyPVWWae--wpKGKSLYTQDPAGNLVELAPA 120
gi 83814326   64 -slpahgaeGPVHVAFGVPT-DQLAAWRRHFNRHDvAVEDttqwgdGQRSLYVRDPAGNSVELVSS 127
gi 222439003  75 givpghdtsGHGHFAFRILN-DQLGPWRDYLSSKGvDIISevvwpaGGTSLYFKDPDGNILELASA 139
gi 198258366  62 -avpshgtsGEGHIAFAATD-EEIREWRVHLESKGiEIESvvewgeGGESLYVRDPAGNSVEFAPS 125
gi 67901840   91 kegdgdidsLKQHFCVAVQStEDVAKWEAYLQKKGvPIISctnwerGGKSIYFADLDGHLAEIASR 156

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