Conserved Protein Domain Family
VOC_CChe_VCA0619_like

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cd08356: VOC_CChe_VCA0619_like 
uncharacterized subfamily of vicinal oxygen chelate (VOC) family
uncharacterized subfamily of vicinal oxygen chelate (VOC) family contains Vibrio cholerae VCA0619 and similar proteins. The VOC superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.
Statistics
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PSSM-Id: 319944
View PSSM: cd08356
Aligned: 18 rows
Threshold Bit Score: 191.746
Threshold Setting Gi: 736598351
Created: 27-Jan-2010
Updated: 18-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15601377    7 LEIKSFVPAQDFTTSKQFYLSLGFELITefgDVAYLRLGQCAFLLQNTHqRPHQGNTMMHLLVEDAQSWFDHVKTLQlee 86
gi 254845484   7 LEIKSFVPAQDFTTSKQFYLSLGFELITefgDVAYLRLGQCAFLLQNTHqRPHQGNTMMHLLVEDAQSWFDHVKTLQlee 86
gi 439973215   7 LEIKSFVPAQDFTTSKQFYLSLGFELITefgDVAYLRLGQCAFLLQNTHqRPHQGNTMMHLLVEDAQSWFDHVKTLQlee 86
gi 498051938   7 IAIQPFVPAKCFSSSIKYYQALGFELVSehsGIAAFRYQSYSFLLQDFYePKHCENYMMHLHVPDLNAWYQHILALEleh 86
gi 518332429   7 VEIKAFVPAQNFEISKAFYRDLGFIMASdedGIAYFYCGNHSFLLQDFYeREHANNFMMHLLVKDVESWYQHILSVGiad 86
gi 490543587   8 VDIKAFIPTTNYELCKAFYQDLGFELKNdmgNLAFFSLGQHNFLLQDLPeAQHISEFMMHLQVEDAKAWHQVLTEKQike 87
gi 800991189   7 IALKTFVPSKNYTQSKAFYSEIGFTKASdtqGVAFYHLGDVSFLLQDFYeKTLAENLVMHLLVEDIGAWHQNLIESGvve 86
gi 511821775   7 IEIKAFIPSKDFETSIQFYQTIGFTLASneqGVAYFHHQNCSFLLQNFYqKQLCDNLMLHWLVKDLDHWHQTISDKLsgs 86
gi 522072749   8 IDLKAFVPSKDYDESKAFYRDVGFSIASdsqGVAFVHDGACSFLLQYFYvKELAENLVMHFQVENVDAWHKRRVDNGise 87
gi 381377818   7 EEIKAFVPARDFARSLDFYQALGFELHWtdgELAYLCHGDCAFLLQDFEaPDFAANYQMHLQVLDVEAWHALARGVAerf 86
                         90       100       110
                 ....*....|....*....|....*....|...
gi 15601377   87 rfeskvtdlitQPWGMLEFCLVDPSDVLWRIGQ 119
gi 254845484  87 rfeskvtdlitQPWGMLEFCLVDPSDVLWRIGQ 119
gi 439973215  87 rfeskvtdlitQPWGMLEFCLVDPSDVLWRIGQ 119
gi 498051938  87 dfsckvtdittQPWGVREFCLYDPSGVLWRVAQ 119
gi 518332429  87 kyqvkvtepedRPWKMRDFILYDPSGVLWRIAQ 119
gi 490543587  88 kyqvqvtpvveQPWGMLDFVVTDPCGVLWRIAQ 120
gi 800991189  87 kydtkitditeQEWGMLDFIMLDPSGVMWRIAQ 119
gi 511821775  87 glafsitpiseQPWGMRDFCLTDPSGVLWRIGE 119
gi 522072749  88 kysiqiseptdQPWQMRDFTFHDPSGVLWRVGQ 120
gi 381377818  87 dts--igtpedRPWAMRDFTLFDPSGVLWRIAQ 117
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