3RRI


Conserved Protein Domain Family
VOC_like

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cd08357: VOC_like 
Click on image for an interactive view with Cn3D
uncharacterized subfamily of vicinal oxygen chelate (VOC) familyprotein, glyoxalase I, and type I ring-cleaving dioxygenases.
The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.
Statistics
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PSSM-Id: 319945
View PSSM: cd08357
Aligned: 10 rows
Threshold Bit Score: 179.502
Threshold Setting Gi: 343197421
Created: 18-Mar-2009
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
putative metal
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1: putative metal binding site [ion binding site], 3 residue positions
Conserved feature residue pattern:H H EClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on homologous proteins in the same superfamily

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         #                                                                     #        
3RRI_A        11 FHLAIPAr-DLDEAYDFYVT--KLGCKLARRYPDRITLDFFGDQLVCHls---------dRWDREVSXYPRHFGITFRDk 78
gi 209585781   1 FHYAFPVh-SLDAAKQFYGD--VLGCAQGRSSEKWQDYSLHGHQIVCHwvgneyrcvdyyNPVDGDEVPVPHAGLALTV- 76
gi 168056169  44 FHLAIPVh-DVQAAREFFGG--VLGCPEGRSAKTWVDFNLFGHQVVCHevrnyn-aatsaNAVDGDPVPVPHFGLAMSV- 118
gi 159028350  80 FHLAIPIt-DVSTAKSFYCD--GLGCLAGRETEKAIILNFYGHQVVAHvt--------emPLTPQNSIYPRHFGLILPDa 148
gi 118473204  11 FHLAMPVd-DLDAARHFYGG--VLGLPQGRSSERWIDWNLHGHQVVTHlaper--arqvhNPVDGHDVPVPHFGLILTV- 84
gi 159471922   5 FHIAIPVr-DVEEARAFYGG--VLSCPEGRSAATWVDFNLFGHQVVAHlvkdyh-gssahNAVDGDPVPVPHFGAALTV- 79
gi 26990045    5 FHVSYHVt-DLEASRNFYGN--ILGCKEGRTSETYVDYDFFGHQISLHkgvpf--pttrtGKVGDHEVLMPHIGLVLHL- 78
gi 167525407  12 HGLDVDQvrSVEAARKFYGD--ILGLTEGRSAPDWVDYNMFGHQVVAHvsprl--nedhtNAVDGHDVPVPHFGCVLDW- 86
gi 226455909  26 FHLAIPVr-DIEEARAFYGPdgVLGLREGRSTATWIDFNFYGHQLVTHlvrgyd-aktshNAVNGDPVPVPHFGLAMDA- 102
gi 33591402   10 FHLAFPVr-DLAEARDFYGA--LLGCPEGRSSPEWIDFNFYGHQIVAHlapqac-gsaatNAVDAHNVPVRHFGAVLSM- 84
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
Feature 1                                                     #    
3RRI_A        79 KHFDNLYKLAKQRGIPFYhDLSRRFEGLIEEHETFFLIDPSNNLLEFKYY 128
gi 209585781  77 GEFHALAERVKKAGVHFIiEPHLRFKGMPGEQWTMFFKDPSGNNLEFKAM 126
gi 168056169 119 PEFHAMAERVRAAGVRFIiEPHIRFVGQPGEQWTMFFKDSSGNALEFKAM 168
gi 159028350 149 SDWDNLLEKARVNQLKFYlEPKTRFNGEITEHKTFFLEDPFYNLLEFKHY 198
gi 118473204  85 DAFHALADRLRTAGATFViEPYVRFEGETGEQWTMFLLDPAGNALEFKAF 134
gi 159471922  80 DQFHALAMQLKSQGVKFAlEPHLRFKGTPGEQWTMFFYDPSGNALEFKAM 129
gi 26990045   79 DDWFAMADRLALHGVQFDiPPVVRFPGQPGEQRTMFFLDPSGNPIEIKGF 128
gi 167525407  87 EGFDRLAARLTAKGVKFIiAPYVRFEGMAGEQKTMFVKDNSNNNLEFKAM 136
gi 226455909 103 ESFRALVARCEERGASFEtAPSLRFEGKPGEQVACFLRDPSGNALEFKAM 152
gi 33591402   85 DQWEALAGKLTDAGTEFViEPYIRFKGEVGEQATMFFLDPSGNALEFKAF 134

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