3VCX


Conserved Protein Domain Family
VOC_like

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cd08359: VOC_like 
Click on image for an interactive view with Cn3D
uncharacterized subfamily of vicinal oxygen chelate (VOC) family
The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.
Statistics
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PSSM-Id: 319947
View PSSM: cd08359
Aligned: 7 rows
Threshold Bit Score: 163.338
Threshold Setting Gi: 283807501
Created: 27-Jan-2010
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
putative dimer
Conserved site includes 23 residues -Click on image for an interactive view with Cn3D
Feature 1:putative dimer interface [polypeptide binding site]
Evidence:
  • None

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ########                                      ##  #               ##########    
3VCX_A        25 TSYYPVIXTSDVAATAAFYCQHFGFRPLFEADWYVHLQSAedp-avNLAILDGqhstip--aagrgQVSGLILNFEVDDP 101
gi 259156243   4 KSASMTIVTQSLPDTRKFYETYFNARPIFDCGWYVILRLTtrhqepEICLMSPqeg-------mqpFSGGAFFNLLVEDA 76
gi 198256083 143 SKLTVGLVSDDIGATRDFYVKHFGFQAVFDASCYVHLSREig--geQIGLMAAtaeagqaefesatTGQGVWISLEVEDV 220
gi 222436245   2 QRAFTNILTEEVAVTAAFYQKLLGYTVKFSSDWFVNLEAPdrt-glELGILLTsheivp--eaarhQPAGIILTFVVDDC 78
gi 283807501   4 AAFGATVVTARPAEVAAFYTQYFDLAVTVDLGWFVCLRRGes--dwELAICERghssvp-aavsatTESSNVFGFVVDDA 80
gi 15805697   53 QALGNVVLTPQPLADAEFYVRHFGFRYAAQLDWYVSLQHAdln-gfFLDFMDGhhpaap--aslqgQTSKPFVAFIVDDA 129
gi 125717183   3 TSLYPVLMSEDVHQAAQFFIDHFQFQESFRSDWYISLKNIes--gfELAFIDSkhgtvp--qayqsKASGLIINIEVDNV 78
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
Feature 1                       #                     #     
3VCX_A       102 DREYARLQQAGl-pILLTLRDEDFGQRHFITADPNGVLIDIIK 143
gi 259156243  77 DELHSRLTQAGl-tPTVPLEDHPWGDRRFGLLDPSGVIVYCYH 118
gi 198256083 221 DAEYERLKGEGl-vFRESPADQPWGERTCVTSDPNGVLIYVSQ 262
gi 222436245  79 DAVHDRASELGa-nIIEAPRDMPYGQRRMILRDPAGTIIDVSS 120
gi 283807501  81 DKVAARLTDGSv-eLATEVVTEPWGQRHFYVRDPEGTWLDVIQ 122
gi 15805697  130 QAEAQRLGQAGl-tLLKPVTDELWGQRRFQVGGPNGAVIEVVQ 171
gi 125717183  79 DCFYEELRQQEemeFLLPIKSEDFGQRHFIVEAPGSVLVDVIQ 121

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