Conserved Protein Domain Family
MhqB_like_C

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cd08360: MhqB_like_C 
C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins
This subfamily contains the C-terminal, catalytic, domain of Burkholderia sp. NF100 MhqB and similar proteins. MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion. The purified enzyme has shown extradiol ring cleavage activity toward 3-methylcatechol. Fe2+ was suggested as a cofactor, the same as most other enzymes in the family. Burkholderia sp. NF100 MhqB is encoded on the plasmid pNF1. The type I family of extradiol dioxygenases contains two structurally homologous barrel-shaped domains at the N- and C-terminal. The active-site metal is located in the C-terminal barrel and plays an essential role in the catalytic mechanism.
Statistics
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PSSM-Id: 319948
View PSSM: cd08360
Aligned: 5 rows
Threshold Bit Score: 236.639
Threshold Setting Gi: 8978309
Created: 22-Sep-2009
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
putative metalputative active
Feature 1: putative metal binding site [ion binding site], 3 residue positions
Conserved feature residue pattern:H H EClick to see conserved feature residue pattern help
Evidence:
  • Comment:predicted based on homologous proteins in the same family.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1             #                                                        #                 
gi 127273    165 PRRLSHVLLFTPSVQRALDFYRDALGLRLSDRSdDVIAFTHApygsDHHLLALVKSSarGWHHAAWDVADVNEVGQGASQ 244
gi 214041750 162 PRRLAHVLVFTPSVPEAIAFYSSTLGLRISDRSgDGICFMHGihgsDHHLIAFAKSSapGLHHCSWDVGGINEIGMGASQ 241
gi 58616650  150 PLRLGHLIKFSPDVDRSVDFYTQLLGMKVSDRAfDILAFLRGaaggDHHMIAFAKSShtGLHHMSFEVSDLDQIEIGAQT 229
gi 3644005   150 PLRLGHLIKFSPDVDRSVDFYTQLLGMKVSDRAfDILEFLRGaaggDHHMIAFAKSShtGLHHMSFEVSDLDQIEIGAQT 229
gi 8978309   144 PRKLGHVVLGSTDLETSMRFFRDGIGFKVSDMIqGRGSFMRCs--tDHHNLLVQNTPvnFVHHSSWQVDDVNEVGRGASR 221
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
Feature 1                                          #                     
gi 127273    245 MAKAGYTQG-WGTGRHVLGSNYFFYVLDPWGSFCEYSADIDYi-pAGQAWPAGDFA 298
gi 214041750 242 MANKGYQKG-WGLGRHVLGSNYFHYVQDPWGSFSEYSADIDYi-pVGHEWEAGDYD 295
gi 58616650  230 LLRAGYKDG-FGLGRHIGGSNYFHYIRDPWGSLVEYFWDIDVipeDDSGWVPLNVG 284
gi 3644005   230 LLRAGYKDG-FGLGRHIGGSNYFHYIRDPWGSLVEYFWDIDVipeDDSGWVPLNVG 284
gi 8978309   222 LLEADPNRHvWGLGRHHIGSNFFWYLRDPSGTFAEYYSDLDTi-lEDELWSPEVFE 276

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