Conserved Protein Domain Family
PpCmtC_N

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cd08361: PpCmtC_N 
N-terminal domain of 2,3-dihydroxy-p-cumate-3,4-dioxygenase (PpCmtC)
This subfamily contains the N-terminal, non-catalytic, domain of PpCmtC. 2,3-dihydroxy-p-cumate-3,4-dioxygenase (CmtC of Pseudomonas putida F1) is a dioxygenase involved in the eight-step catabolism pathway of p-cymene. CmtC acts upon the reaction intermediate 2,3-dihydroxy-p-cumate, yielding 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate. The CmtC belongs to the type I family of extradiol dioxygenases. Fe2+ was suggested as a cofactor, same as other enzymes in the family. The type I family of extradiol dioxygenases contains two structurally homologous barrel-shaped domains at the N- and C-terminal. The active-site metal is located in the C-terminal barrel and plays an essential role in the catalytic mechanism.
Statistics
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PSSM-Id: 319949
View PSSM: cd08361
Aligned: 26 rows
Threshold Bit Score: 168.927
Threshold Setting Gi: 808659630
Created: 20-Mar-2009
Updated: 18-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5360706     1 MIELKDVAYARLGTPDLEDAESFATSCLGLQVAKRSg-----KALHLRSDNRAHTLCYYNGD-PSEQTLGFEIADkDKLS 74
gi 517528478   1 MIELKDVVYCRLGTRDLEGAEWFAVNILGLEVAERHr-----GAIHFKSDSRYHTLCYFEGD-PDEQVTAFEVAGrSELQ 74
gi 950147647   1 MIVLKDISYVRLGTRDLDGACRYANDILGLREGQRYgpprhgKAVGFRSDAREQTLVYFDGA-PADHTTGFEIASmAELQ 79
gi 947719982   2 GAHLHDIRYVRIGSDDLDESVRFATDILGLEVVHRDa-----GAAYLRGDDRDHNICYTKGR-STGQVLGFEMPDmASLD 75
gi 739627940   2 TINIIDVAYVRLKTPDLDSASEFATRILGLELIDRAg-----DLHSFRSDQRMTTLSYERGD-PAEATVGFELASgEELE 75
gi 489558552   1 MINLHDICYLRLGCHDLDEMVRFATGILGLELRERTa-----THAYLRGDSSAFNLCYIQGD-ASYDVSAFELRHlAELK 74
gi 495528147   3 GALVKDIAYVRIVTSNFVESIDFAVNVLGLEISFKDk-----NKAYLRSDDRYCTICYEYGV-NSEQVVGFEIDGpNELR 76
gi 493590403   1 MIELEDIAYVRSGASDLDAAVRFATDIVGMELIAREg-----DTAYLRADQRHHCLALVGGS-SGVLASGLLVRDeDVLE 74
gi 808659630   1 MIELQDIAYVRSGVTDLERAERFAVDIVGLDPVARAp-----GTTYLRADHRHHCLALVESSqAGVHASAFTVKDdAALE 75
gi 702849234   1 MITLTDIAYVRSGAADLEKATRFSTEIVGLQQVDTGe----pGVAHLRADHRHHSLALVEGP-SGVIASAFTVADdDQLA 75
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 5360706    75 SAATTLESIGHPVHvgtdsdcavRKVKAFIGFKDPSGNSIELVVRPERLG 124
gi 517528478  75 AAAATLEQLGHPVHagtaeecatRHVREFIRFTDPTGNGIELVVRPEHSG 124
gi 950147647  80 SAAAELERLGHAVHegradeceqRRVQAFIGFKDPSGNAIELAVAPFHSG 129
gi 947719982  76 AAAAMFEKAGVAVRhgtsdereqRRVRGLITLRDPTGNVIDLVARPDHSG 125
gi 739627940  76 NAAGTLEDMGFAVRrgsrtecehRQVSDFIAFSDPGGGRIEFALAPHVAG 125
gi 489558552  75 TAESELATQGIEVNwgtpaeceeRRVEAFVAFTDPNDNRIELVYRPHQTG 124
gi 495528147  77 VATNALEERGVPLRwgtreecaeRHVEEFISFSDPSGNMIEMVTYPEYTG 126
gi 493590403  75 DAERELERAGVRVTrgsakqahaRRVQAFVGFDDPFGNHVELVCGQATVS 124
gi 808659630  76 AAEAELTSYGCTVRrgsaeearqRHVRAFIAFDDPFGNHVELVTDQSTLA 125
gi 702849234  76 HAETELEQRGIRVTrgdadaarsRHVTRFIGFDDPFGNRVELVTGQETMA 125
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