4JD1,4NB1


Conserved Protein Domain Family
FosB

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cd08363: FosB 
Click on image for an interactive view with Cn3D
fosfomycin resistant protein subfamily FosB
This subfamily family contains FosB, a fosfomycin resistant protein. FosB is a Mg(2+)-dependent L-cysteine thiol transferase. Fosfomycin inhibits the enzyme UDP-nacetylglucosamine-3-enolpyruvyltransferase (MurA), which catalyzes the first committed step in bacterial cell wall biosynthesis. FosB catalyzes the Mg(II) dependent addition of L-cysteine to the epoxide ring of fosfomycin, (1R,2S)-epoxypropylphosphonic acid, rendering it inactive. FosB is evolutionarily related to glyoxalase I and type I extradiol dioxygenases.
Statistics
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PSSM-Id: 319951
View PSSM: cd08363
Aligned: 10 rows
Threshold Bit Score: 221.456
Threshold Setting Gi: 588293047
Created: 20-Mar-2009
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
putative Mgputative active
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1: putative Mg binding site [ion binding site], 3 residue positions
Conserved feature residue pattern:H H EClick to see conserved feature residue pattern help
Evidence:
  • Comment:putative Mg(II) binding site
  • Comment:predicted based on binding of Mn(II) to a homologous protein FosX.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          #                                                          #                  
4JD1_A         6 INHICFSVsNLEKSIEFYQKilQAKLLVKGrKLAYFDLNGLWIALNveeDIPRNEIKQSYTHMAFTVTNEALDHLKEVLI 85
gi 57012764    5 INHMTFSVsNMDKAVSFYKHvfMEAPLVLGeKTAYFTIGGTWLALNlqpDIDRKEIRQSYTHIAFSIEESQLDAFYTRLL 84
gi 28380031    6 VNHICFSVsDLNTSIQFYKDilHGDLLVSGrTTAYLTIGHTWIALNqekNIPRNEISHSYTHIAFSIDEEDFQQWIQWLK 85
gi 57012775    9 INHLLFSVsDLSVSISFYEKvfDAKWLVKAeKTAYFDLNGIWLAFNeekDIKRQEIHDSYTHIAFSIQQEDLPFWEKKLH 88
4NB1_A        12 INHICFSVrNLNDSIHFYRDilLGKLLLTGkKTAYFELAGLWIALNeekDIPRNEIHFSYTHIAFTIDDSEFKYWHQRLK 91
gi 759009898   6 INHLTFSVvNLEASIAFYRDvlEGTLLVQGeRMAYFDLQGIWLALNvqeDIPRTEITHSYTHIAFTIDEQDFPVYVQRLQ 85
gi 938929037   5 LNHITFSVsNLEQTVAFYKQvfLIDPVVYGqKTAYFDINGMWLALNvqdQIPRNDVYHTYTHLAFSINKEEIDAFLERLH 84
gi 518253978   7 LNHLCFSVsNLDSSIAFYRDilEGKLLALGrKLAYFDCQGLWIALNq-eDVDRSNRDVTYTHIAFSIDERDYDAVKQRLL 85
gi 755076722   3 INHITFSVsHLKKSIEFYETalDAKILVEGeRMAYFDLAGVWLALNvqtDIPRNEISHSYTHMAFTVTPEELQMKKENFT 82
gi 914624054   5 INHITVSVsDLNRSIAFYQDvfGAKLIVHGpRMAYFDLDGLWLALNe-eNLPDRTFSNTYTHIAFTICEDQLDEFTEKLK 83
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
Feature 1                                       #                    
4JD1_A        86 QNDVNILPGRERder-dqrSLYFTDPDGHKFEFHTGTLQNRLEYYKEDKKHM 136
gi 57012764   85 EAGADILPGRKRqvetegkSIYFRDPDGHLLEVHTGTLAERLAHYEKTAPDM 136
gi 28380031   86 ENQVNILKGRPRdik-dkkSIYFTDPDGHKIELHTGTLKDRMEYYKCENTHM 136
gi 57012775   89 DLGVNVLKGRKRheg-drdSIYFSDPDGHKFELHTGSVFDRLQYYQNEKPHL 139
4NB1_A        92 DNNVNILEGRVRdir-drqSIYFTDPDGHKLELHTGTLENRLNYYKEAKPHM 142
gi 759009898  86 KLGVTIREGRSRdka-eaqSVYFTDPDGHLFEFHTGNREQRIQHYKDEKKPM 136
gi 938929037  85 LSGAEIVEGRTRdilsegqSLYFRDPDGHLLEVHTGSLAERLEHYKKNAPEM 136
gi 518253978  86 DYGVTVLEGRERaqe-dkrSIYFLDPDHHCFEFHTGTLEARLQYYRSSKRHI 136
gi 755076722  83 KVGISYDEGRDRdkgreghSIYFSDPDGHRFELHTGSRDQRIEYYKEEKKPM 134
gi 914624054  84 RNGAVIEKGRKRhll-ekdSIYFRDPDGHLFEFHTGTLTDRISYYKSQQANM 134

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