4GYM


Conserved Protein Domain Family
VOC_like

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cd09012: VOC_like 
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uncharacterized subfamily of vicinal oxygen chelate (VOC) family
The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.
Statistics
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PSSM-Id: 319954
View PSSM: cd09012
Aligned: 10 rows
Threshold Bit Score: 168.33
Threshold Setting Gi: 261357188
Created: 8-Jul-2010
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4GYM_A        10 LTFVNLPVADVAASQAFFGTLGFEFNpkFTDES-CACXvvs---eqaFVXLIDRARFADFtskpia------datattEA 79
gi 16804475    7 QIFINLPVKDLQATVAFFTELGYEFNpqFTDEN-ATQMlig---dniFAMLLKEDFFQTFhkegia------dttkarEV 76
gi 27377519   62 MIFVNLPVTDLKRATAFYEAVGAVRNpqFCDDT-ASCMvfs---etiFAMLLTHDKFRQFtpkpia------daktsnQV 131
gi 119196243 157 KIFINLPSKDLEASKRFAFGLGLKKKfeGSGEM-QTVVfvya--dniLIMYHAHPTWERWlfegrkt----adahsttQA 229
gi 19552166    8 MIFINLPVSDLAASKRFYAGLGFKENtvFSDEH-TASFevs---daiVVMLLETARFSDFtkrpiv------ekngsrEV 77
gi 15673301    4 MVFVNFPVTDIKKSTAFYEKIGFKKNpdLSDEL-VSCMiwd---knfFIMLLSRARYKTFigekeia-----dtksssSA 74
gi 15965916    3 MIFVNLPVKDLKASRSFFSALGFTFNeqFSDET-AACMvid---dniFAMLLTEPKFRSFivgeis------dtakgtEV 72
gi 261357188   6 TFFINASTSSPEEAKVFYTALGFTPAe-WCDVPtTKALnlpapneniCLMVHAVDCFKKFippdatv----adpaktnET 80
gi 171682632  12 TFFVNLPTINLEKATAFFVALNFDHIklWSDDK-SSAFrlpgassqvSLMIHIHERFKTFnrpdtsv----vdafkstEA 86
gi 240107672   4 PVFINLSTTKLSAATTFYETMGFIKHpfFSSEH-GHAMvhsr-nhdiVVMISSADHFQKFipasrripettidevsknVV 81
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
4GYM_A        80 IVCVSAIDRDDVDRFADTALGAGGtvard----pxdyGFXYGRSFHDLDGHLWEVXWX 133
gi 16804475   77 LITITQDSRQAVDKLVDRAFEIGAkqage----tqdyDFMYSRSFLDLDNHLWEIAYL 130
gi 27377519  132 LLCLSADSRDEVDAIVGKAEVAGGvadps---pkdeySFMYGRSFEDPDGHMWGVNWM 186
gi 119196243 230 LLTLSAESAEEVESMVSKAVDAGGrrgpqm-apdndqYGMYSRSVEDPDGHVFEIVYA 286
gi 19552166   78 LNCLSVCSTEDADEFVRRAQEFGGtitre----laaeGPMYGGAFDDPDGHGWELMYF 131
gi 15673301   75 LISFTFANAQSVKDFGKLADENGGksihld--ngipeEMMYGLEVQDPDGNCLEPVWM 130
gi 15965916   73 ITALSAASRAECDDMFDKAIAAGGkpwkp----aidyGFMYGISFQDLDGHVWEFMWM 126
gi 261357188  81 LLTIAVNSRDEVDALLAKAVAAGGksdpytmkdhgaeMGMYVRSFTDLDGHLWEAFFM 138
gi 171682632  87 LFSFMAKDKASVDAFIEQAVNAGGkadpyvlknygqdMGMYNRSFEDLDGHIWEVCSM 144
gi 240107672  82 LLGLPAKSKQEVDELVERAASAGGkafpavkvegcdeSMMYTRAFADLDGYLWEMVWC 139
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