Conserved Protein Domain Family
PhsB_like

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cd10553: PhsB_like 
uncharacterized beta subfamily of DMSO Reductase similar to Desulfonauticus sp PhsB
This family includes beta FeS subunits of anaerobic DMSO reductase (DMSOR) superfamily that have yet to be characterized. DMSOR consists of a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and the tungsten-containing formate dehydrogenase (FDH-T). Examples of heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.
Statistics
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PSSM-Id: 319875
View PSSM: cd10553
Aligned: 13 rows
Threshold Bit Score: 223.78
Threshold Setting Gi: 550907206
Created: 29-Jan-2014
Updated: 18-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973012945   2 SIYYLFHDRSRCIGClSCQIHCKQNKNLTnpAPKPCQIFTfg-pkLIQGKVKVaNIFVSCFQCDNPWCVKACPTGALYKR 80
gi 493468474   2 SKYYLFQDVKNCINCrSCEVTCKSNKNLPp-GPRLCEVIAvg-psLIGGLPRAaYTFMPCFHCEDPWCVAACPTGAMQKR 79
gi 494786215   2 STYCIVTDERRCISCkACEIHCKVKNAMPv-GIKLGEHFTegplpSASGAPLFrTLYMPCFHCEEPECVDVCPTGAMTKR 80
gi 516756874   2 SNYYLYHDSHKCISChACEVQCKVNKGLPl-GPRPNQVIAvg-pmLVSGQPRAnFVFISCFHCEQPWCVAACPNGAMRKR 79
gi 550905184   2 SKYIVMHNSADCIGCkACEVQCRSLHNGGp-GAFFCRVLSv---eQTEPKPALgFVYTSCFHCENPWCVKACPTGAMRRR 77
gi 494503873   2 NNYMLYLNSKRCIGChGCEIHCKSNKRLPe-GPSLCEISHep-lkMVGRIPKTeFQFRSCYHCDDPHCVPVCPTGAMLKR 79
gi 550907206   2 AAYRIKLDKSRCIACmACLVHCKQKNRVPq-GLSLNKLFAel--eDKDGKPVLkVKYQPCLMCKNPECVPACPTGAMQKR 78
gi 551229978   2 AKYYIYHDPTRCIGClACELSCMDWKGLPf-GEANCRIFRsg-pdMFHGKPRLmFLYNSCFHCERPFCVEACPTGALFKR 79
gi 492836818   2 SKYMIQLDKKRCIAChACEVHCQVKNGVPa-SAKPGKLVSvg-pdMAKGKPRLlNLYMSCYHCEKPWCVPACPTGAMTRR 79
gi 972622635   2 SEYVITQNQRKCIGClACVVHCKVENNLPi-GPRFCDILPvg-pkDVNGIPRIyFVYMNCFHCEDAFCVRACPTGAMTRR 79
gi 390623240  16 DRVHLFHDSERCIGCySCELHCKMKNNLPv-GPRLCRIIEig-prTRQHTLKMdFHFLPCFHCENPFCANVCPTGAIQKR 93
gi 78218527    2 SRYRLKLNKKRCIHCkACEVHCKAKNNTPa-GIKLGVHTSse-pvMVDGVPRMkAAYQCCYHCETPECVDVCPTGAMIRR 79
gi 206889773   2 SIYYIYQDHDRCIGCyACEVHCKTKNELPv-GPRLCRIIEtd-ikLIGGLPRQrFVFMPCFHCEDPWCVKACPTGAMQKR 79
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 973012945  81 EkDGIVAMDRSLCIGCKSCIVACPFGAPQWDPsSHTVVKCDFCVNRLEQGLKPACVENCTTGCLYFGT 148
gi 493468474  80 QkDGIVFVDHSVCVGCKTCMSACPWGAPQWSEeMGKVVKCDYCKDRIDQGLDPACVTVCTTHCLHFGR 147
gi 494786215  81 EaDGIVYVEADDCIGCGACLEACPWHIPQWNEdGDKAVKCDLCMDRIDTGLKPACVTGCTTHALILTG 148
gi 516756874  80 EqDGIVYVDQNLCKGCKSCIMACPWSSPQWDArLGKVVKCDLCKDRLDKGEKPACVQACPVDCLQLVA 147
gi 550905184  78 D-DGIVYVETSACVGCKACITACPWAAPQWNAqTGKVDKCDLCRDRIDQGLKPACVTTCAMSCLQFST 144
gi 494503873  80 A-DGIVYVDQEKCTGCVACVGACPWNIPQLNPaTGKVVKCDFCLDRVDVGLKPACVTRCTAHALRFVA 146
gi 550907206  79 EsDGLVFIDEELCIGCGECIEACPWDVPVLDEaRGKAIKCDYCMDRIKEGRDPACVTGCTAHALSFLR 146
gi 551229978  80 EsDGIVMFKSDLCIGCRACIMACPWGIPQWNSlEGKIHKCDYCVERIDEGLEPACVTRCPMDALKFVR 147
gi 492836818  80 EdDGVVYVREELCVGCKACIQACPWRIPQWNEaTGKVVKCDYCRDRIDAGLDPACVTGCTAHALRFVR 147
gi 972622635  80 EkDGIVYVRDELCIGCKSCMKACPWGIPQWNPeTGKVFKCHLCMHRLDRGEKPACVEGCTTSCLSFVL 147
gi 390623240  94 VkDGIVFVDSKLCIGCKCCIAACPWGVPQWNPeTGKIVKCDYCMDRIDKGLKPACATGCLTQCLHFGK 161
gi 78218527   80 EsDGIVYVDQETCIGCEACIDACPWHIPVFNAaTATVLKCDFCMDRVDEGKLPACVTACTTHALSFTR 147
gi 206889773  80 SkDGIVFVEQSLCVGCKSCITACPWGVPQWNPeTGKVVKCDYCKDRVDQGLKPACVTKCTTKALKFVS 147
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