Conserved Protein Domain Family
FDH_b_like

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cd10562: FDH_b_like 
uncharacterized subfamily of beta subunit of formate dehydrogenase
This subfamily includes the beta-subunit of formate dehydrogenases that are as yet uncharacterized. Members of the DMSO reductase family include formate dehydrogenase N and O (FDH-N, FDH-O) and tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N, a major component of nitrate respiration of Escherichia coli, is involved in the major anaerobic respiratory pathway in the presence of nitrate, catalyzing the oxidation of formate to carbon dioxide at the expense of nitrate reduction to nitrite. It forms a heterotrimer; the alpha-subunit (FDH-G) is the catalytic site of formate oxidation and membrane-associated, incorporating a selenocysteine (SeCys) residue and a [4Fe/4S] cluster in addition to two bis-MGD cofactors, the beta subunit (FDH-H) contains four [4Fe/4S] clusters which transfer the electrons from the alpha subunit to the gamma-subunit (FDH-I), a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. W-FDH contains a tungsten instead of molybdenum at the catalytic center. This enzyme seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It is a heterodimer of a large and a small subunit; the large subunit harbors the W site and one [4Fe-4S] center and the small subunit, containing three [4Fe-4S] clusters, functions to transfer electrons.
Statistics
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PSSM-Id: 319884
View PSSM: cd10562
Aligned: 19 rows
Threshold Bit Score: 237.201
Threshold Setting Gi: 931366415
Created: 20-Jan-2016
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Fe-S cluster
Feature 1:Fe-S cluster binding site [ion binding site]
Evidence:
  • Comment:Predicted based on similar proteins.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #      #### ##   #   #                         # #                   #  ####    
gi 494499368   6 YCYDSSKCVGCHGCQVACKQWNeektl---atrfaGSYQNPPDLDKDTRMVMRYYEHFeqdtipSLNFLKYQCFHCGEAA 82
gi 560300672   6 KYVDVTKCDGCRACMVACKNWNdlpae---peefqGSVQSHANVTANTWNVLSFIEHEdakgnlDYLFRHSSCFHCSEAA 82
gi 297141975   5 KLVDVTRCDACRACQVACKNWNdlpsd---iqaygGSYQSHEKVNGKTWNVLQMKEYEngs-gfEWLFRHSACYHCEDAA 80
gi 77996511    4 MFIDTSLCVGCRGCMTACKSWNelpge---kttftGSLQSMPDTTPKTYTLIKFYEREeng-riRFDFFKQQCFHCGDAA 79
gi 114337271   6 NLYDVSKCTACRGCQVACKDWNqlpav---iepfkGNYQTHKDTNGDTYTIVKFMEYEdpvdgvQWNFLKYQCMHCFDPA 82
gi 114338274   6 VFIDTSLCTGCKACSVACKAWNdhpae---ktqriSSYQAQADFTPNTWTYVRFREEYkdk-kmRFNMLKLQCFHCGDPA 81
gi 409105620   7 YLVDTTKCIACRGCVVACKQWNqlpae---qtrftGSYQTVPDLTGNTFTIISFHEYEedg-riRWYFAKRQCMHCLEPV 82
gi 260849298   7 MLHDIARCSACRACMVACKQWHdlpadm--stpfeGQYQSHATLTPTTWTLIRMTEHTddkgkfNWDFVKTQCMHCGDPA 84
gi 931366415   6 MLIDTSKCTACRGCQVACKQWNelpeetttffptnKGYQNPPDLTANTYCLVEFFSSEtsegdpEWLFRKRQCMHCTDAE 85
gi 51857924   23 MLVDTSECIGCKGCEVACKQWNqnear---inqdpGTYQSHPALDAETWTVIRFFETEeengmsMWLMQKHSCMHCTDAG 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #   ##  ##        #         ####   ### ##               # #####                 
gi 494499368  83 CVKVCPsGALFKTKt-GIVAVDREKCIACGYCHNACPFNIPAVG----------KHVNKCDMCRSRTENGqdgdktnvPA 151
gi 560300672  83 CVKVCPeEAMHYTDf-GTVNVDSDKCVGCGYCVQNCPFDVVQLAtykdkngkeyKKAQKCTMCVDRLEEGm------qPA 155
gi 297141975  81 CEKVCPeGAISTTDm-GNVVIDQEQCVGCSYCTQNCPFDIVELAdyvnqdgetvQRAQKCTMCDDRIHNGl------qPA 153
gi 77996511   80 CEKACPeDAIYHTKe-GAVVRDYDRCIGCDYCQRACPFNIPRIDtq-------nKKMHKCTLCFDRLENGe------iPA 145
gi 114337271  83 CMKVCPrQAYSKTEw-GATFHDPDKCIGCQYCTYACPFEVPKYRkr-------eDKITKCTLCVDRVEAGl------tPA 148
gi 114338274  82 CMKACSsNAIYKTEt-GYTLIDKDKCIGCGYCAANCPWGVPKIDea-------tNKSTKCTGCIDRVENGm------kPA 147
gi 409105620  83 CMKVCPqKAISITDt-GAVVRDNDKCVGCQYCAAACPFHIPRYNpt-------tDKETKCSLCAERTAEGd------lPA 148
gi 260849298  85 CAKGCPeEAIDKLAs-GAVVINEEKCVGCGYCVANCPFDVPKINpq-------tHKSTKCDLCFDRIEEGi------tPS 150
gi 931366415  86 CVELCPyDAAQKDTdtGFVVFDEEKCKGCGLCVDNCPFEAPRLTap------qnGKSKKCFACLYPYDRLsege-epkPA 158
gi 51857924  100 CVTACPtDALQYGDy-GLVTLNQDACIGCGYCEAACPFDCIHVDrtaw--gqraQKAGKCTFCYDRIAQGm------qPA 170
                        170
                 ....*....|....*...
Feature 1        #   #    #        
gi 494499368 152 CVKTCPAGALEFGDRDQL 169
gi 560300672 156 CVTTCHTDAMEFGTQEEM 173
gi 297141975 154 CADVCHMDAIVFGTKEEM 171
gi 77996511  146 CALTCSPGAIKYGNRDEL 163
gi 114337271 149 CARTCPTGALTFGPRDEL 166
gi 114338274 148 CAQTCQPGAIQFGDHAEI 165
gi 409105620 149 CVKACITGALEYGNRDEL 166
gi 260849298 151 CAKTCTADALQFAPYEEI 168
gi 931366415 159 CAKTCPSGAITYGDRTTM 176
gi 51857924  171 CVATCPTDCIKYGDRDAL 188

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