Conserved Protein Domain Family
CooF_like

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cd10563: CooF_like 
CooF, iron-sulfur subunit of carbon monoxide dehydrogenase
This family includes CooF, the iron-sulfur subunit of carbon monoxide dehydrogenase (CODH), found in anaerobic bacteria and archaea. Carbon monoxide dehydrogenase is a key enzyme for carbon monoxide (CO) metabolism, where CooF is the proposed mediator of electron transfer between CODH and the CO-induced hydrogenase, catalyzing the reaction that uses CO as a single carbon and energy source, and producing only H2 and CO2. The ion-sulfur subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons in the protein complex during reaction.
Statistics
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PSSM-Id: 319885
View PSSM: cd10563
Aligned: 56 rows
Threshold Bit Score: 158.958
Threshold Setting Gi: 492824898
Created: 29-Jan-2014
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Fe-S cluster
Feature 1:Fe-S cluster binding site [ion binding site]
Evidence:
  • Comment:predicted based on similar proteins.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         #      #### ##   #   #                  # #                   #  ####    #   ##
gi 490532285   3 KIYVKEEVCVGCRLCEVYCITSHSkykdvlkafkletqrPTPRIVIEenk---------pvSFSLQCRHCDDAPCVKSCI 73
gi 39996340    3 RIYMIEDACIGCHLCEVGCITEHSaskdpvraylheperPIARCTVEeidg-------givSFSTTCRHCDEPDCLRACI 75
gi 550921073   3 VVKIKEDNCVYCHLCEVACIVEHSqskdiik-afkreerPIARCSVEfny---------pvSLSVMCRHCDDAPCMEACQ 72
gi 551219619  15 KVYPIEENCISCRYCEVACTMVHSeskdpikaykledllPRPTVEVEgp-----------vSLSVMCRHCKHPFCLDACI 83
gi 495053266   3 KLFFISKHCDGCQACEAACLEKHSqsqslfm-sklerpsPQPRIRVRqsg---------nqYWATICQHCTDSMCVRACM 72
gi 91203867    3 KKKFIKSKCVTCKQCMIECAVRHSssrnly---daftenPKSQYRLQvsir-------kdhPYMTVCQNCAKPKCMASCE 72
gi 374856181   3 RLFCDSRRCVGCRACEIACAVEHTpskdlfv-svlngelGLPRRRVQtvgaqpyrvaiggvVLSLGCHHCDPAPCVDACI 81
gi 965596767   8 RVLPIEENCMGCRLCEVACAIEHSefkdpil--tffqgkPQSFTVVEvdg---------pfSFSLNCRHCDEPYCVEACI 76
gi 815057718   2 KVVAWTEYCLGCGLCEIYCAAQHDgyngnvl-kifkkgrPMHRSRLLkae---------qgTWLNTCMHCTHAPCINGCI 71
gi 390525208   3 KIYFQPQRCDGCLACEQVCREKHSktqslfn-skveiplAKPHIRLSgld---------grYSVSICQNCVHASCVEACM 72
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
Feature 1          ##        #         ####   ### ##           # #####             #   #    #   
gi 490532285  74 TGAMQKDplTGVVICDTDKCVGCWTCVLVCEFGAIIRDvn---nKVASKCDLCAEAg------ePACVKNCPNEALVYR 143
gi 39996340   76 SGAIQKNd-QGVVRIDTEQCVGCWSCVMACPYGAIQRNlk---kKKANKCDLCPDRm------sPACVDACPNRALVYK 144
gi 550921073  73 NGSMHRDe-RGYVVVNPDTCVGCWMCIMACPYGVIKRDtrrevwGLSTKCDLCPDRe------iPACVEACPNEALTFE 144
gi 551219619  84 SGAIWQDk-NGVVHLDEDVCVGCWSCVLVCPFGAVHPHln---kRHSFKCDLCEGRd------fPACVEACPNRALVYD 152
gi 495053266  73 TGAMKFSp-MGEVFHNPDKCVGCWMCIMVCPFGAIASRse---iKKASKCDLCKDEk------tLPCVASCSQQALFYG 141
gi 91203867   73 YGAITKYe-DGNVVIDTAKCVGCWECVSACPFGAITKNte---lKYAFNCDDCKGFd------tMACVEACKTGALVYV 141
gi 374856181  82 TGAMHKE--NGQTVCDTEKCVGCWMCVMSCPYGAITPK------VKALKCDLCPDRrervgrarYACVEACPTEALFAG 152
gi 965596767  77 TGAMHKEp-DGRVIVYEDICIGCYMCVVSCPWGAVNPKeg---vKKAAKCDLCPDRe------lPACVQACPNRALVFD 145
gi 815057718  72 SGAIKRDp-NGIVYVDYERCVGCYSCVMLCPHGHVRPWse---rHQVLKCDLCRDTg------lPSCVANCPNGALQLV 140
gi 390525208  73 AGALRYSd-EGNVIHDAEQCVGCYMCVMVCPFAAIAPQet---tGKAGKCQLCLDEe------qPPCVLACSRKALLFG 141

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