Conserved Protein Domain Family
7tm_V1R_pheromone

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cd13949: 7tm_V1R_pheromone 
vomeronasal organ pheromone receptor type-1 family, member of the seven-transmembrane G protein-coupled receptor superfamily
This family represents vomeronasal type-1 receptors (V1Rs) that are specifically expressed in the vomeronasal organ (VNO), which is the sensory organ of the accessory olfactory system present in amphibians, reptiles, and non-primate mammals such as mice and rodents, but it is non-functional or absent in humans, apes and monkeys. The VNO detects pheromones, chemicals released from animals that can influence social and reproductive behaviors, such as male-male aggression or sexual mating, in other members of the same species. On the other hand, the olfactory epithelium, which contains olfactory receptor neurons inside the nasal cavity, is responsible for detecting odor molecules (smells). There are two types of vertebrate pheromones: (1) small volatile molecules such as 2-heptanone, a substance in the urine of both male and female that extends estrous cycle length in female mice; and (2) water-soluble molecules such as the major histocompatibility complex (HMC) class-I peptide, which can induce the pregnancy block effect, the tendency for female rodents to abort their pregnancies upon exposure to the scent of an unknown male. While V1Rs and G-alpha(i2) protein are co-expressed in the apical neurons of the VNO, V2Rs (type-2 vomeronasal receptors) and G-alpha(o) protein are coexpressed in the basal layer of the VNO. Activation of V1R or V2R causes stimulation of phospholipase pathway, generating diacylglycerol (DAG) and inositol 1,4,5-triphosphate (IP3). V1Rs have a short N-terminal extracellular domain, whereas V2Rs contain a long N-terminal extracellular domain, which is believed to bind pheromones. Although V1Rs share the seven-transmembrane domain structure with V1Rs and olfactory receptors, they share little sequence similarity with each other.
Statistics
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PSSM-Id: 320087
View PSSM: cd13949
Aligned: 34 rows
Threshold Bit Score: 264.901
Threshold Setting Gi: 68566196
Created: 22-Dec-2011
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:TM helix 1 [structural motif]
Evidence:
  • Comment:All members of this receptor family contain a seven-transmembrane helix domain.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         ##########################                                                     
gi 68566197    5 YVAVGMILSQTVVGVLGSFSVLLHYLSFYCtgcrLRSTDLIVKHLIVANFLALRCKGVPQTMAAFgvrYFLNAlGCKLVF 84
gi 68566195    5 DFAIGMILSQIMVGFLGNFFLLYHYSFLHFtrgmLQSTDLTLKHLTIANSLVILSKGIPQTMAAFglkDSLSDiGCKFVF 84
gi 146337173  87 PVGLDPTLFQVVVGILGNFSLLYYYMFLYFrgykPRSTDLILRHLTVADSLVILSKRIPETMATFglkHFDNYfGCKFLL 166
gi 68566227    6 FAIGMILLSQIMVGFLGNFFLLYHYSFLCFtrgmLQSTDLILKHLTIANSLVILSKGIPQTMAAFglkDSLSDiGCKFVF 85
gi 68566194    5 YVAVGMMLSQTVVGVLGSFSLLLHYLSLHYigcrLRSADLIVKHLIAASFLTLLCKGVPQTMAAFrvrYFLNAiGCKLVF 84
gi 81917238   11 TEIRNAIYSGVGIGISGNSFLLLFHIFKYIrgqrSRHIDLPIGLLSLIHLVMLIAMSLVATDIFMp-wGRWGDtTCKCVI 89
gi 81909739   11 AYIRDVFFCEIGVGISANSCLLLFHIFMFIrghrPRLTDLPIGLMALIHLLMLLLAAYIAKDFFMs--SGWDDiTCKLFI 88
gi 81909750   11 VDKQAIFFSEVVIGISFNSILFLFHIFQFLlerrLRITDLIISLLALIHLGMLTVMGFRAVDIFAs-qNVWNDiKCKSLA 89
gi 81917232   11 VYIRNAFFSEIGIGISANSCLLLFHTFMFIrghrPRLTDLPIGFVALIHLVMLLLAAYITEDFFMs-sGGWDDiTCKLVI 89
gi 68566193   43 ITIQIFFYPQASFGISANTILFLFHIFTFVfshrSKSIDMIISHLSLIHILLLFTQAILVSLDFFgsqNTQDDlRCKVIV 122
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 68566197   85 YLHRVGRgvsIGTTCLLSVFQVITVSsrksRWAKLKek-aPKHVGFSVLLCWIVCMLVNIIFPMyvtgkwny-tnitvne 162
gi 68566195   85 YVHRVGRavcTGNACLLSVFQVITISssefRWAELKlhahKYIRSFILVLCWILNTLVNITVPLhvtgkwns-instktn 163
gi 146337173 167 YAHRVGRgvsIGSTCLLSVFQVITINprnsRWAEMKvk-aPTYIGLSNILCWAFHMLVNAIFPIyttgkwsn-nnitkkg 244
gi 68566227   86 YVHRVGRavcVGNACLLSVFQVITISpsefRWAELKlhahKYIRSFILVLCWILNTLVNITVLLhvtgkwns-instktn 164
gi 68566194   85 YLHRVGRgvsTGTTCLLSVFQVITVSsrksRWAKLKek-aPKHVGFSVLLCWILCMLVNIIFPIyvtgkrnhtnitvnkd 163
gi 81917238   90 SLYRFCRslsLCATSLLSILQAVTLNprnsCLEKFKrk-sPHYMLGCLLFLSVFYTFISSPLATyitaksnl-tspsfty 167
gi 81909739   89 FLHRFFRslsVCATCMLSVFQTIILCpqssHLAKFKpn-sPYHLSCFFIFMSIFYTSISSHILIaaiatqnl-tsvnliy 166
gi 81909750   90 HLHRLLRglsLCATCLLSIFQAITLSprssCLAKFKyk-sTQHSLCSLLVLWAFYMSCGTHYSFtivadynf-ssrslif 167
gi 81917232   90 FLHRFFRslsVCATCLLSVFQAIILCpqssHLAKLKqn-sPHQLSYFFIFLSIFYTSISSHILIaaiptqni-tfvnliy 167
gi 68566193  123 FLNKVMRglsICTPCLLNVLQAIISPsi-fSLAKLKhp-sASHILGFFLFSWVLNMFIGVIFCCtlwlpp------vkwg 194
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 68566197  163 dLGYCSGGgnnkIAQTLRAMLLSFPDVLCLGLMLWVSSSMVCILHRHKQRVQHidr-----sdlSPRASPENRATQSILI 237
gi 68566195  164 dYGYCSGGsrsrIPHSLHIVLLSSLDVLCLGLMTLASGSMVFILHRLKQQVQHihg-----tnlSPRSSPESRVTQSILV 238
gi 146337173 245 dLGYCSAPlsdeVTKSVYAALTSFHDVLCLGLMLWASSSIVLVLYRHKQQVQHicr-----nnlYPNSSPGNRAIQSILA 319
gi 68566227  165 dYGYCSGGsrsrIPHSLHIVLLSSLDVLCLGLMTLASGSMVFILHRHKQQVQHihg-----tnlSARSSPESRVTQSILV 239
gi 68566194  164 lGDCCGRGnn-kIAQTLRAMLLSFPDVLCLGFMLWASSSMVCILHRHKQRVQHihr-----snlSPRASPENRATQSILI 237
gi 81917238  168 iTTSCSLApmsySFHLTVFILLTSRDVIFVGLMLLSSGYMVTFLGRHKKQSQFlhi-----tsfSLKPSAEKRAMRTILC 242
gi 81909739  167 iTKSCSFLpmssSMQRTFSTLLAFRNAFLIGLMGLSTCYMATLLCRHKTRSQRlqn-----sklSPKATPEQRAIWTLLM 241
gi 81909750  168 vTESCIILpmdyITRHLFFILGIFRDVSFIGLMALSSGYMVALLCRHRKQAQHlhr-----tslSPKASPEQRATRTILL 242
gi 81917232  168 iTNSCSFLplssSMQHTFSTLLAFRNVFVIGLMGLSTCYMATLLCRHKTRSQRlqn-----sklSPKATPEQRALRTILM 242
gi 68566193  195 qSSVCHTAlf-lFAHELHPQETVFHTNDFEGCHLYRVHGPLKRLHGDYFIQTIrgylsaftqpaCPPVSPVKRASQTILL 273
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
Feature 1                                                                       
gi 68566197  238 LVSTFVSSYTLSCLFQVCMalldnpnSLLVNTSALMSVCFPTLSPFVLMSCDpsvYRFCFAWK 300
gi 68566195  239 LVSTLCYFTRSPPSLHMSLfpn--psWWPLNASALITACFPTVSPFVLMSRHpriPRLGSACC 299
gi 146337173 320 LVSTFALCYALSFITYVYLalfdnssWWLVNTAALIIACFPTISPFVLMCRDpsrSRLCSICC 382
gi 68566227  240 LVSTLCYFTRSPPSLHMSLfpn--psWWLLNTSALITACFPMVSPFVLMSRHpriPRLGSACC 300
gi 68566194  238 PVSTFVSSYTLSCLLQVCMalldnpnSLLVNTSALMSACFPTLSPFVLMSCDpsvYRLCFAWK 300
gi 81917238  243 LMSFFVLMYTLDSIVSYIRsid-dgqIFYCVHIFTAHGYATVSPFLILSTEKyiiNIFRSTFG 304
gi 81909739  242 FMSFFLVMSTFDSIISYSRtifqgnpSLYCAQILVAHSYAVVSPMLVLSNENrltNPLISMYE 304
gi 81909750  243 LMSFFVLMYCLDCTISASRlmhngepIHHSIQMMVSNSYATLSPLLLIVTENrisRFLKSLLG 305
gi 81917232  243 LMSFFLLMSTFDSIISYSRtilqgnpLPFCFQILVAHSYAAVSPLLVLSNEKritNLLISMYE 305
gi 68566193  274 LVSFVFIYWVDFMFSFSRGvtwindsLLVWFQVIVANSYATISPLMLIYADNqifKTLQMLWF 336

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