Conserved Protein Domain Family
7tmA_OR

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cd13954: 7tmA_OR 
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.
Statistics
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PSSM-Id: 320092
View PSSM: cd13954
Aligned: 116 rows
Threshold Bit Score: 257.027
Threshold Setting Gi: 38372712
Created: 23-Dec-2011
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #  ##           ###### #
gi 209572776  25 IIFFAVILASYLLTLVGNLTIILLSRLDARlhtpMYFFLSNLSSLDLAFTTSSVPQMLKNLwgpdKTISyggCVTQLYVF 104
gi 38372682   23 SVCFVVFLPVYLATVVGNGLIVLTVSISKSldspMYFFLSCLSLVEISYSSTIAPKFIIDLlakiKTISlegCLTQIFFF 102
gi 14423802   27 FLFFIVFTAVYVFIIIGNMLIIVAVVSSQRlhkpMYIFLANLSFLDILYTSAVMPKMLEGFlq-eATISvagCLLQFFIF 105
gi 212276448  63 ILLFVLFTVVYLLTLMGNGSIICAVHWDQRlhapMYILLANFSFLEICYVTSTVPSMLANFlsdtKIISfsgCFLQFYFF 142
gi 14423826   23 PFFFGIFLIIYLINLIGNGSILVMVVLEPQlhspMYFFLGNLSCLDISYSSVTLPKLLVNLvcsrRAISflgCITQLHFF 102
gi 74760322   25 MTLFVLFLPFYACTLLGNVSILVAVMSSARlhtpMYFFLGNLSVFDMGFSSVTCPKMLLYLmglsRLISykdCVCQLFFF 104
gi 74760323   46 APLFLAFLVIYLLTVSGNGLIILTVLVDIRlhrpMCLFLCHLSFLDMTISCAIVPKMLAGFllgsRIISfggCVIQLFSF 125
gi 160417202  30 LPVFFIFLLFYLLILMGNALILVAVVAEPSlhkpMYFFLINLSTLDILFTTTTVPKMLSLFllgdRFLSfssCLLQMYLF 109
gi 557017957  27 RFLFPFFLAAYLVTLTGNMLILIAVKTSHKlhtpMYFFLANLSVIDILYTTTTLPKMLSKLllddKVISftgCFLQMFFF 106
gi 557017961  27 LLLFVFFLTVYLVTLTGNMLILIATRTSHKlhtpMYFFLANLSVLDILYTTTTLPKMLSKLllsdKTISftgCFLQMYFF 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #                                            # #####                         
gi 209572776 105 LWLGaTECILLVVMAFDRYVAVCRPlhYMTVMnPRLCWGLAAISWLGGLGNSVIQstftlqLPFCGhrkVDNFlCEVPAM 184
gi 38372682  103 HFFGvAEILLIVVMAYDCYVAICKPlhYMNIIsRQLCHLLVAGSWLGGFCHSIIQilviiqLPFCGpnvIDHYfCDLQPL 182
gi 14423802  106 GSLAtAECLLLAVMAYDRYLAICYPlhYPLLMgPRRYMGLVVTTWLSGFVVDGLVvalvaqLRFCGpnhIDQFyCDFMLF 185
gi 212276448 143 FSLGsTECFFLAVMAFDRYLAICRPlrYPTIMtRRLCTNLVVNCWVLGFIWFLIPivnisqMSFCGsriIDHFlCDPAPL 222
gi 14423826  103 HFLGsTEAILLAIMAFDRFVAICNPlrYTVIMnPQVCILLAAAAWLISFFYALMHsvmtahLSFCGsqkLNHFfYDVKPL 182
gi 74760322  105 HFLGsIECFLFTVMAYDRFTAICYPlrYTVIMnPRICVALAVGTWLLGCIHSSILtsltftLPYCGpneVDHFfCDIPAL 184
gi 74760323  126 HFLGcTECFLYTLMAYDRFLAICKPlhYATIMtHRVCNSLALGTWLGGTIHSLFQtsfvfrLPFCGpnrVDYIfCDIPAM 205
gi 160417202 110 QSFTcSEAFILVVMAYDRYVAICHPlhYPVLMnPQTNATLAASAWLTALLLPIPAvvrtsqMAYNSiayIYHCfCDHLAV 189
gi 557017957 107 LSFGtIECFTLVVMAYDRYVAICDPlrYNTKItKEVCILLAASAWVLGFALIFPAviltaqLPYCGpnsVYHCfCDHSAV 186
gi 557017961 107 LSLQtVECLILAVMAYDRYVAICDPlrYNSKMtKQVYILFAATAWLLGFVFPSPTvilalwLPYCGpntVNHClCDHSSV 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                  #  ### ### ##                                             #  ## ##  # 
gi 209572776 185 IKLACgdtslNEAVLNGVCTFFTVVPVSVILVSYCFIAQAVmki-rsvEGRRKAFNTCVSHLVVVFLFYGSAIYGYLLPa 263
gi 38372682  183 FKLACtdtfmEGVIVLANSGLFSVFSFLILVSSYIVILVNLrnh--saEGRHKALSTCASHITVVILFFGPAIFLYMRPs 260
gi 14423802  186 VGLACsdprvAQVTTLILSVFCLTIPFGLILTSYARIVVAVlrv-pagASRRRAFSTCSSHLAVVTTFYGTLMIFYVAPs 264
gi 212276448 223 LTLTCkkgpvIELVFSVLSPLPVFMLFLFIVGSYALVVRAVlrv-psaAGRRKAFSTCGSHLAVVSLFYGSVLVMYGSPp 301
gi 14423826  183 LELACsdtllNQWLLSIVTGSISMGAFFLTLLSCFYVIGFLlfknrscRILHKALSTCASHFMVVCLFYGPVGFTYIRPa 262
gi 74760322  185 LPLACadtslAQRVSFTNVGLISLVCFLLILLSYTRITISIlsi-rttEGRRRAFSTCSAHLIAILCAYGPIITVYLQPt 263
gi 74760323  206 LRLACadtaiNELVTFADIGFLALTCFMLILTSYGYIVAAIlri-psaDGRRNAFSTCAAHLTVVIVYYVPCTFIYLRPc 284
gi 160417202 190 VQASCsdttpQTLMGFCIAMVVSFLPLLLVLLSYVHILASVlri-sslEGRAKAFSTCSSHLLVVGTYYSSIAIAYVAYr 268
gi 557017957 187 LKLACtdtivNNILGLSIALTVLVIPCILILVSYVKIIISVlki-asgEGRRKAFSTCVSHLIVVIIFFSSACFTYISFr 265
gi 557017961 187 LKLACtntivNNMLGLSIALAVLLIPCILILVSYVKILTSVlki-asgEGRRKAFSTCVSHLIVVSIFFLSACFTYISYr 265
                        250       260       270
                 ....*....|....*....|....*....|..
Feature 1             ## ###  #  ##              
gi 209572776 264 k-ssNQSQGKFISLFYSVVTPMVNPLIYTLRN 294
gi 38372682  261 ---sTFTEDKLVAVFYTVITPMLNPIIYTLRN 289
gi 14423802  265 a-vhSQLLSKVFSLLYTVVTPLFNPVIYTMRN 295
gi 212276448 302 s-knEAGKQKTVTLFYSVVTPLLNPVIYSLRN 332
gi 14423826  263 s-atSMIQDRIMAIMYSAVTPVLNPLIYTLRN 293
gi 74760322  264 ---pNPMLGTVVQILMNLVGPMLNPLIYTLRN 292
gi 74760323  285 ---sQEPLDGVVAVFYTVITPLLNSIIYTLCN 313
gi 160417202 269 a-dlPLDFHIMGNVVYAILTPILNPLIYTLRN 299
gi 557017957 266 ipsvTVDFRIMCVVLYAFLTPMLNPIIYCLRN 297
gi 557017961 266 ipsvTMDFRIMCVVLYAVLTPMLNPIIYCLRN 297

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