Conserved Protein Domain Family
7tmD_STE2

?
cd14939: 7tmD_STE2 
fungal alpha-factor pheromone receptor STE2, member of the class D family of seven-transmembrane G protein-coupled receptors
This subfamily represents the alpha-factor pheromone receptor encoded by the STE2 gene, which is required for pheromone sensing and mating in haploid cells of the yeast Saccharomyces cerevisiae. The STE2-encoded seven-transmembrane domain receptor is a member of the class D GPCRs. Class D receptors are composed of two major subfamilies: Ste2 and Ste3. These two GPCRs (Ste2 and Ste3) sense the polypeptide mating pheromones, alpha-factor and a-factor, which activate a G protein-coupled receptors on the surface of the opposite yeast-mating haploid-types (MATa and MAT-alpha), respectively. Activation of these receptors by pheromones leads to activation of the mitogen-activated protein kinase (MAPK) signal transduction cascades, G1 cell cycle arrest, and polarized cell growth in the direction of the partner cell (a process called shmooing), which ultimately induces cell-cell fusion and the formation of a diploid zygote. Like all GPCRs, these pheromone mating factor receptors possess the same basic architecture of seven-transmembrane (7TM) domains and share common signaling mechanisms; however, there is no significant sequence similarity either between Ste2 and Ste3, or between these two receptors and the other 7TM GPCRs. Thus, STE2 and STE3 represent phylogenetically distinct groups.
Statistics
?
PSSM-Id: 320093
View PSSM: cd14939
Aligned: 81 rows
Threshold Bit Score: 195.42
Threshold Setting Gi: 573064583
Created: 22-Dec-2011
Updated: 26-Jul-2017
Structure
?
Aligned Rows:
  next features
Feature 1:TM helix 1 [structural motif]
Evidence:
  • Comment:All members of this receptor family contain a seven-transmembrane helix domain.

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                 #########################                                              
gi 313471481  41 LQGLVNSTVTQAIMFGVRCGAAALTLIVMWMTSRSRKt------PIFIINQVSLFLIILHSALYFKYLLSNYSSVTYALT 114
gi 212001250  36 IDSMERNRLLTGMTVAVQVGLGSFILVLMCIFSSSEKrk----kPVFIFNFAGNLVMTLRAIFEVIVLASNNYSIAVQYG 111
gi 149239244  34 FDSFHKDQLIGVIILGVTIGACSLLLILLLGMLYKSReky-wksLLFMLNVCILAATILRSGCFLDYYLSDLASISYTFT 112
gi 344303744  42 LDDYQRRVLESSIVFGVSIGACSVILLLLFVVSYNNRkkklfksFLFNLNAAILLVYIIQSGLNLNYLMSRLSSPSFFIT 121
gi 562974030  32 LDSYVKANAEVAAIFGMRIGLAAIAVPAIFFVTRNKRs------VLFVLNEVCMATMLIHGIMTVCTMFEAYRSLAFNFS 105
gi 266500     38 IDAYERDRLLTGMTLSAQLALGVLTILMVCLLSSSEKrk----hPVFVFNSASIVAMCLRAILNIVTICSNSYSILVNYG 113
gi 49650839   35 LEQLYQNRLRLAILFGVRVGAAVLTLIAMHLISKKNRt-----kILFLANQMSLIMLIIHAALYFRFLLGPFASMLMMVA 109
gi 124110808  27 FDEFSLSRAQTSMIFSAQCAMSLLLAIVLILTSKREKrk----tLLFFLNIGGLITVFIRACLQCAYLSGTWVSYSVQFL 102
gi 549044571  52 LSNIQYLAITWSACFAIQIGAATILFCLLPLLSNPSRrr----sLPFLCNMITLAIVILRGILHIYYYFSPFTTPYRLFT 127
gi 339477213  45 IVYFMGLAVKSTLIFAIQIGISFVLMLVIALLTKPERrv----tLVFFLNMTALFTIFIRAILMCTTFVGTYYNFYNWIM 120
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 313471481 115 gfpqfi--srgdvhVYGATNIIQVLLVASIETSLVFQIKVIftgd--nfkRIGLMLTSISFTLGIATVTMYFVSAVKGMI 190
gi 212001250 112 fafaav--rqyvhaFNIIILLLGPFILFIAEMSLMLQVRIIcsq----hrPTMITTTVISCIFTVVTLAFWITDMSQEIA 185
gi 149239244 113 gvyng-----tsfaSSDAANVFKTIMFALIETSLTFQVYVMfqgt--twkNWGHAVTALSGLLSVASVAFQIYTTILSHN 185
gi 344303744 122 gayyg-----esfaMTDTANAFRVILVGLVQISLTYQVYIIfkgh--rlnIWSVSATLFSTLFSITVVAFTINSVVLAHR 194
gi 562974030 106 gylyvd---khasdLSAATNVIYVILIGLTEASLTYQVHIVfrgpsfhykNVGFGMVAVCGLLGLASTVLYFIYAVMSNI 182
gi 266500    114 filnmv--hmyvhvFNILILLLAPVIIFTAEMSMMIQVRIIcah----drKTQRIMTVISACLTVLVLAFWITNMCQQIQ 187
gi 49650839  110 yivdprsnvsndisVSVATNVFMMLMIMSVQLSLAVQTRSVfha----wlKSRIYVTVGLILLSLVVFVFWTTHTIVSCI 185
gi 124110808 103 gefell--sqkdfyVSIIASCIPIFIILFIELSLLIQIRVVyat----ekKLQIPLTIAFSIIIIVVIIFWILAAVQNSM 176
gi 549044571 128 eeyigi--pmsariISIASAITTLLLKAMVQFSLIIQLRILfqn----reGIKNALTIGTSLLAAVSTGIYVWIVVLSTE 201
gi 339477213 121 gnypns---gladrVSIAAEVFAFLIILSLELSMMFQVRIVcin---lssFRRRIITFSSIVVAMIVCTVRFALMVLSCD 194
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 313471481 191 Vtyn-------dvsATQDKYFNASTILLASSINFMSFVLVVKLILAIRSRRflgLKQFDSFHILLIMSCQSLLVPSIIFI 263
gi 212001250 186 Yqlflkn-ynmkqiVGYSWLYFIAKITFAASIIFHSSVFSFKLMRAIYIRRkigQFPFGPMQCIFIVSCQCLIVPAIFTL 264
gi 149239244 186 Nfnati---sgtgtLTSGVWMDLPTLLFAASINFMTILLLFKLGMAIRQRRylgLKQFDGFHILFIMFTQTLFIPSILLV 262
gi 344303744 195 Knsaft---hgqerNFVSLWNDLPVWLFSININIMSVLLILKLGMAIRTRRylgLKQFDGLHILVIMSTQTLIIPSIILF 271
gi 562974030 183 Alyd-------insSVPMWVMNASQICYASSSFIISVILSCKLFVAIRTRKflgLKQFSIFHVLFIMALQTMIIPTILVL 255
gi 266500    188 Yllwltp-lssktiVGYSWPYFIAKILFAFSIIFHSGVFSYKLFRAILIRKkigQFPFGPMQCILVISCQCLIVPATFTI 266
gi 49650839  186 Vlthp-----trdlPSMGWTRLASDVSFACSISFASLVLLAKLVTAIRVRKtlgKKPLGYTKVLVIMSTQSLVVPSILII 260
gi 124110808 177 Avlsqth-fghsglWGSPWPYTVARISFAFSIFIGCMVFIYKLLITIYRRHkmgVKEFGPLQIIFIMSCQTLIIPAILIL 255
gi 549044571 202 Vilqep----vghsSPNSRLTFASKVTFAGSITVFSALLVGKLLVAIKERRalgLKKFGVFKIALVLGLQTMFIPAIFTI 277
gi 339477213 195 WrivnigdatqeknRIINRVASGYNICTIASIIFFNTIFVSKLAVAIKHRRsmgMKQFGPMQIIFVMGCQTLLIPAIFGI 274
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
Feature 1                                                    
gi 313471481 264 Layslk--pnqgtDVLTTVATLLAVLSLPLSSMWATAANNASKT 305
gi 212001250 265 Idsft-----htyDGFSSMTQCLLIISLPLSSLWATHTAQKLQT 303
gi 149239244 263 Ihyfyq---amsgPFIINMALFLVVAFLPLSSLWAQTANTTKKI 303
gi 344303744 272 Vhyfgi---snvgSMLVKVSMLLIVLTLPLTSLWAQTQNNTENI 312
gi 562974030 256 VsfrevkgssgpdKALNAVGTALIAISLPLTTMWANTAVNETSS 299
gi 266500    267 Idsfi-----htyDGFSSMTQCLLIISLPLSSLWASSTALKLQS 305
gi 49650839  261 Vnyalp---eknsWILSGVAYLMVVLSLPLSSIWATAVHDDEMQ 301
gi 124110808 256 Vdfg------vkiTGFSSLTQALVVMSLPLSSLWASSKVENNKN 293
gi 549044571 278 Vdsf------vdlDGLISFTPALAGMFLPLASMWASAKHDSPDT 315
gi 339477213 275 Isyfa-----lasTQVYSLMPMVVAIFLPLSSMWASFNTNKTNS 313

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap