Conserved Protein Domain Family
7tmD_STE3

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cd14966: 7tmD_STE3 
fungal a-factor pheromone receptor STE3, member of the class D family of seven-transmembrane G protein-coupled receptors
This subfamily represents the a-factor pheromone receptor encoded by the STE3 gene, which is required for pheromone sensing and mating in haploid cells of the yeast Saccharomyces cerevisiae. The STE3-encoded seven-transmembrane domain receptor is a member of the class D GPCRs. Class D receptors are composed of two major subfamilies: Ste2 and Ste3. These two GPCRs (Ste2 and Ste3) sense the polypeptide mating pheromones, alpha-factor and a-factor, which activate a G protein-coupled receptors on the surface of the opposite yeast-mating haploid-types (MATa and MAT-alpha), respectively. Activation of these receptors by pheromones leads to activation of the mitogen-activated protein kinase (MAPK) signal transduction cascades, G1 cell cycle arrest, and polarized cell growth in the direction of the partner cell (a process called shmooing), which ultimately induces cell-cell fusion and the formation of a diploid zygote. Like all GPCRs, these pheromone mating factor receptors possess the same basic architecture of seven-transmembrane (7TM) domains and share common signaling mechanisms; however, there is no significant sequence similarity either between Ste2 and Ste3, or between these two receptors and the other 7TM GPCRs. Thus, STE2 and STE3 represent phylogenetically distinct groups.
Statistics
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PSSM-Id: 320097
View PSSM: cd14966
Aligned: 179 rows
Threshold Bit Score: 184.241
Threshold Setting Gi: 400223
Created: 14-Feb-2014
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:TM helix 1 [structural motif]
Evidence:
  • Comment:All members of this receptor family contain a seven-transmembrane helix domain.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         #########################                                                      
gi 74620537    5 STIIGLCLLAVILLVPPLAWHSHTKNIPAiiLITWLLIMNITCIVDAAIWSDDDFLTrwd-gkgWCDIVIKLQVGANIGI 83
gi 549051758   6 HIFRTLTAVSLILCCMPLVWHIRYKNFPAvfLIVWISFFSISSFVNSFIWPDNNSIQhgwngkvYCDIQIKLKVAAFAGN 85
gi 430813492   4 VFYVIYSFIGFICSVIPSIWHWKYRNVAPlcLIFWISACSLICFINSIVWFNGVEAKspg--yiYCDIATKIILGSTSGE 81
gi 565934020   8 LVLAPLALLAVLAAIPPLIVQVRARNFPAsvLIAGVTILNIQNFVNAAIWHSLDTSRwwn-gkiLCDIEVKLYLGTTQAM 86
gi 11596247    4 AFYIFFCLIGFLCSIIPSIWHWKYRNVAPlcLIFWVSSTNLVYFINSIIWYNGSETSyrg--dlYCDIVTKLILGSVTGE 81
gi 568118029   9 IAYTPLALLSLILSVPSLVIQGRARNFPTivLIACIAVLNLQNVANAFIWPGWGDNPweg--riFCDIEIRLYAALPTAV 86
gi 400223      6 IFYQFYAYFALVLSIPILYMQLRARNIPCllLLFWLTLTTLIYVVESAIWSNPYAETirwmgygLCDITSRIVTCSSIGI 85
gi 528318678   6 IFYQVYAYFSLVLSVQVFYMQMRARNLPCllLLFWVCICSLIYAVQSAIWHDTSEPKwlg--ygFCDLTSRIITSSSIGI 83
gi 345565720  87 GFFVFCSITAIIGLVVPFIWQIRRENVAAalLCFWLQTDLLFCLTDAIIWPTWKSVItgwqgrgYCDFVIKWKLAAEFGA 166
gi 526202152  80 YIFAICCFSSIILLIIPFIWQVRKRNLAAaiLVFWLQSDLLLSFINALIWPTWVSVVtgwqgkgYCDFVVKWKIAAEFGG 159
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 74620537   84 SCAVTNIIYNLhailkadsv---lpdlsswtkIVKDLVISLFTPVMIMGFSYLLQVFRYGIArynGCQNLLSPTWITTIL 160
gi 549051758  86 LGALAAISRNLarvvsrktig--eskserkraLIQDTMLCVGAPIFMTITHYVVQPSRYDLLpvaGCTVTVAQTWPAVFL 163
gi 430813492  82 LGAIAAISHYLskimspvhss-vqtktirrrqAIEDLLMSFTCPIIMICLHYVIQSARYVINgvnGCVPWSDQSWPTVII 160
gi 565934020  87 GGAIASIFRQIsiilhpthiavaptprqrqitLVIESILCIVLPVYVMVGHYLTQRTRYWVRlssGCIATFDINYAAPFL 166
gi 11596247   82 LGATAAITHYLskimkpsysf-lqskitrrnqAIEDLLFSFGPPIMIMSLHYIVQPARYVIDgtsGCMPWTDRSWLAVAI 160
gi 568118029  87 AGADASLFRQLaaavrtdrvdlvptkgqryrkWTFDLSLCVLFPIIVMSTQYFMSNGRFYVVvviGCTPSIQSNWVAYFL 166
gi 400223     86 PASAFTLVLYLdtvirrdh------plkryenWIWHVCLSILLPLIIMAMMVPLESNRYVVIcmnGCYSSFYQTWYTLLF 159
gi 528318678  84 PASAFTLVLYLdkvirsdr------plkpfqdWVFQILLSLVFPLVIMALMVPMESNRYVVIcmnGCMPAFYQTVYTLIF 157
gi 345565720 167 INAAVMCIMLTicrlfwglsmyretkkmkrqrMMYEWGLVGLFPILLAGLHYVVQPSRYYLTpvfGCHPPIDNSWLSLII 246
gi 526202152 160 INACVFCVMITiyrmfvgvgmyreskkskrtrMLYEWTIGGLFPVILAGLHYVVQPNRYYLTpvyGCHPPIDNSWVSLII 239
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 74620537  161 YTMWMLIWSFVGAVYATLVLFVFYKKRkdvrdilhctnsglnLTRFARLLIFCFIIILVMFPFSIYTFVqdlqqvdghys 240
gi 549051758 164 QFIWSPIMAVVAAFYSIVVIIRVQQHRrqfseil-sgsttinKSRFWRLFGLAIVLLLILVPITFFTLFqhlkhgikpys 242
gi 430813492 161 VLIWPPIFGSISAYYSAKVIYLYFKKQkefqnvlrdsktsmtLSRFVRLIGICSLLVTVYLPLNIYMLYtnifliiqski 240
gi 565934020 167 TYLWPLVVSLIGSTYCLISILRLKQHRnqmasvl-shtlgatTSRFYRLFALACTLLAIYCPLSLVSFVqdiripmhkys 245
gi 11596247  161 VLLWPPVFGSISAYYSVKVIISYIKKRnefqtvlkdsktsmtLSRFIRLIGLSSLIITIYLPLNIYLLIaniaeiirsni 240
gi 568118029 167 QLGWALLSALIATVYCTIAVARVVRHRrqisgvl--atsgmrTDRYIRLFTLGAVGLALSLPHPLLAAIglwvtgstgda 244
gi 400223    160 FYIPPCLLSFGGLFFVSRIVVLYWRRQrelqqff-qrdsqltSKRFLRLLCLAAVFFLGYFPLTIFMVVangklqqflpf 238
gi 528318678 158 FYLPPCLLSLGGLFFVSRILYYYWHRQkelqqff-qrdsqltSKRFLRLLLLDAVFFLGYFPLTLYLLIvnckghkfmav 236
gi 345565720 247 LGWPLLLSTAALGFTIVAFYKINKHLAertvidi-frsdsslDTSFQRLYLIGALFTLIYYPTNIYGFVqfclspmlpyd 325
gi 526202152 240 VGWPFVFSSSAAVLVFMIVHKMKKHLAernlmgf-ltsthtiDSGFRRLYMMVTLFLVIYWPTNLYGVVsfcmtpmlpyd 318
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
Feature 1                                                                
gi 74620537  241 fkn-----thsstiwntiikfdPGRPIYNIWLYFLMSYLVFLIFGLGSDALDMYSK 291
gi 549051758 243 wrs-----vhnhewqvieripmEGAIEFETWISPCAGILIFCFFGIGGEATRIYKG 293
gi 430813492 241 nysw----dhvhqwghgiaylkNDKISFNLWLIPSNSIVVFIFFGMGSDAIVMYKE 292
gi 565934020 246 wpdihppdwserfilgqdtaqsERYIIVDRWAQVLTAYLAFLFFGLGQEATQMYKG 301
gi 11596247  241 kysw----shvhnwssiifyvsKSNMPFNRWLSPSSGIIIFIFFGMGSDAIVMYKE 292
gi 568118029 245 iswrkshppwwadmilrmsvdgVSEQLVTRGSQIVLGFIVFALFGLGREANLFYST 300
gi 400223    239 nhe-----lveawhqesityypTTKVGLNDWVPPTVLYLMSLFFSTSGGWTEKVAL 289
gi 528318678 237 dhy-----lmslwhrvpvdffqATSIYLNNWIPPTVLIVMSIFFITSGKWTDKVAI 287
gi 345565720 326 wda-----vhadwwdtiykfpdNPHFQYQRWIKVVASWILGIVFGFGPEAEKIYWD 376
gi 526202152 319 wga-----vhadwwgtiykfpdNQSFQYQRWIKVIAGWALFLIFGRGAEAEFIYWD 369

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