Conserved Protein Domain Family
7tmA_Mrgpr

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cd14973: 7tmA_Mrgpr 
mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined. Also included in this family is Mas-related G-protein coupled receptor 1-like (MAS1L) which is only found in primates. The angiotensin-II metabolite angiotensin is an endogenous ligand for MAS1L.
Statistics
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PSSM-Id: 320104
View PSSM: cd14973
Aligned: 18 rows
Threshold Bit Score: 226.752
Threshold Setting Gi: 48428096
Created: 23-Sep-2008
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:
  • Comment:based on the structures of some class A family members with bound ligands (peptides or chemicals), agonists, or antagonists
  • Comment:Small-molecule chemical ligands tend to bind deeper within the receptor core, compared to a peptide ligand neurotensin, which binds towards the extracelllular surface of its receptor.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                  #  ##              ###
gi 50401107   14 LIPDLMIIIFGLVGLTGNAIVFWLLGFRMHrt---aFLVYILNLALADFLFLLC-HIINSTVDLlkftlp-kgifaFCFH 88
gi 115502418  24 LIILSLTEGLGLGGLLGNGAVLWLLSSNVYrn---pFAIYLLDVACADLIFLGC-HMVAIVPDLlqgrldfpgfvqTSLA 99
gi 547920     76 NIIAPKAVLVSLCGVLLNGTVFWLLCCGATn----pYMVYILHLVAADVIYLCC-SAVGFLQVTlltyhgvvffipDFLA 150
gi 440897958  27 VALRSLAVVVALCGLVGNGIVIWFVHLSHKkt---sFIIYSLNLAIADFMNLGF-QILFSVRQIlkpflnhcfglhALFM 102
gi 24638055   45 AVMNYIFLLLCLCGLVGNGLVLWFFGFSIKrn---pFSIYFLHLASADVGYLFS-KAVFSILNTggflgtfadyirSVCR 120
gi 81916654   35 HTYFLVSLVICSLGLAGNGLLIWFLIFCIKrk---pFTIYILHLAIADFMVLLC-SSIMKLVNTfhiyn---mtleSYAI 107
gi 126333722  43 EFVRCLTLFTCICGVIGNGIVLWLLSFHIKrt---pFSFYVLSLAASDFTYLFL-EVIWVINYLlyrpmf-qnivnLLTN 117
gi 50401085   28 LVLSSLAMFTCLCGMAGNSMVIWLLGFRMHrn---pFCIYILNLAAADLLFLFSmASTLSLETQplvnt--tdkvhELMK 102
gi 149551704  41 IVIYTLMLLTSLAGLAGNSLVLWFLGFQIKrn---pFTVYILHLAGADFSFLLW-QATLSAISVgppisleyedlhTVIG 116
gi 48428096   30 GWDTVFLVALLLLGLPANGLMAWLAGSQARhgagtrLALLLLSLALSDFLFLAA-AAFQILEIRhgghwplgtaacRFYY 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ### ##  #                                          # #####                      
gi 50401107   89 TIKRVLYITGLSMLSAISTERCLSVLCPiwyhcrrpEHTSTVMCAVIWVLSLLICILDGYFCgyldnhyfNYSVCqa--- 165
gi 115502418 100 TLRFFCYIVGLSLLAAVSVEQCLAALFPawyscrrpRHLTTCVCALTWALCLLLHLLLSGACtqff-gepSRHLCrt--- 175
gi 547920    151 ILSPFSFEVCLCLLVAISTERCVCVLFPiwyrchrpKYTSNVVCTLIWGLPFCINIVKSLFLty----wkHVKACvi--- 223
gi 440897958 103 VLRWFFYLTGLGIMTAISFQRCLSALFPiwyrchcpKHLSAIVSTLLWILTFLLNVLRGYACgql--ftkEEKFCde--- 177
gi 24638055  121 VLGLCMFLTGVSLLPAVSAERCASVIFPawywrrrpKRLSAVVCALLWVLSLLVTCLHNYFCvflg-rgaPGAACrh--- 196
gi 81916654  108 LFMIFGYNTGLHLLTAISVERCLSVLYPiwyqcqrpKHQSAVACMLLWALSVLVSGLENFFCile--vkpQFPECry--- 182
gi 126333722 118 MGLHVTFTVGLGLLASISSQRCLSILFPiwyrnhhpKRGPMVVCGILWLMSLLLNPPKVYYCvvrm-eelPPSGCdl--- 193
gi 50401085  103 RLMYFAYTVGLSLLTAISTQRCLSVLFPiwfkchrpRHLSAWVCGLLWTLCLLMNGLTSSFCskf--lkfNEDRCfr--- 177
gi 149551704 117 LVKYTSYTSGLGLLTAISAERCLSVLFPiwyrcsrpKHLSAVVCSLIWTLSILVNVLDRFFCnfs--lyiSFTDCfk--- 191
gi 48428096  109 FLWGVSYSSGLFLLAALSLDRCLLALCPhwypghrpVRLPLWVCAGVWVLATLFSVPWLVFPeaav-wwyDLVICldfwd 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                 #  ### ### ##                                        #  ## ##  #       
gi 50401107  166 -----wDIFIGAYLMFLFVVLCLSTLALLARLFCGAr----nMKFTRLFVTIMLTVLVFLLCGLPWGITWFLLfwia--- 233
gi 115502418 176 -----lWLVAAVLLALLCCTMCGASLMLLLRVERGPq----rPPPRGFPGLILLTVLLFLFCGLPFGIYWLSRnll---- 242
gi 547920    224 -----fLKLSGLFHAILSLVMCVSSLTLLIRFLCCSq----qQKATRVYAVVQISAPMFLLWALPLSVAPLITdf----- 289
gi 440897958 178 -----fKTATAVSVFLQFSVLGISSLLLLRRVQASSq-----KHQPRKFYLVLLLSFLGFLFGLPLSIIRFCTte----- 242
gi 24638055  197 ----mdIFLGILLFLLCCPLMVLPCLALILHVECRArr---rQRSAKLNHVILAMVSVFLVSSIYLGIDWFLFwvf---- 265
gi 81916654  183 ----vyIFSCILTFLVFVPLMIFSNLILFIQVCCNLk----pRQPTKLYVIIMTTVILFLVFAMPMKVLLIIGyysss-- 252
gi 126333722 194 -----mSKLSGTLMLSMLILMTLSSLILFIRVLWSAk----rYKPKKLVILILLTVSVFLLCAVPHGINHSVFnwr---- 260
gi 50401085  178 ----vdMVQAALIMGVLTPVMTLSSLTLFVWVRRSSqq--wrRQPTRLFVVVLASVLVFLICSLPLSIYWFVLywlsl-- 249
gi 149551704 192 -----tNVAIATLIFLICVLMGLSSLKLLVQVRSRSr----rHPPAKLYWVILITVLVYFTCGLPMGIYWYLLfwfk--- 259
gi 48428096  188 seelslRMLEVLGGFLPFLLLLVCHVLTQATACRTChrqqqpAACRGFARVARTILSAYVVLRLPYQLAQLLYlaflwdv 267
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
Feature 1             ## ###  #  ##                                       
gi 50401107  234 --pgvFVLDYSPLLVLTAINSCANPIIYFFVGs-FRQRLNkq-tLKMVLQKALQDTP 286
gi 115502418 243 --wyiPHYFYHFSFLMAAVHCAAKPVVYFCLGs-AQGRRLp---LRLVLQRALGDEA 293
gi 547920    290 ---kmFVTTSYLISLFLIINSSANPIIYFFVGs-LRKKRLke-sLRVILQRALADKP 341
gi 440897958 243 ----kIHIFNDICVLLSCVNSTANPAIYFFIGg-LQRERSme-tLKVVLQRALGEET 293
gi 24638055  266 --qipAPFPEYVTDLCICINSSAKPIVYFLAGr-DKSQRLwe-pLRVVFQRALRDGA 318
gi 81916654  253 -lddsVWDSLPYLNMLSTINCSINPIVYFVVGs-LRRKRSrk-sLKEALQKVFEEKP 306
gi 126333722 261 --amyNHTFHEISYFLSCVNSSANPLIYFFIGs-LKHQRLke-pLRVVLQRALRDDS 313
gi 50401085  250 -ppemQVLCFSLSRLSSSVSSSANPVIYFLVGs-RRSHRLptrsLGTVLQQALREEP 304
gi 149551704 260 --dwkMSYFHAITELLSCVNSFTNPIIYVLVGt-HWKRRFre-pLRARFQRAFRLEP 312
gi 48428096  268 ysgylLWEALVYSDYLILLNSCLSPFLCLMASadLRTLLRs---VLSSFAAALCEER 321

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