Conserved Protein Domain Family
7tmA_RNL3R

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cd14976: 7tmA_RNL3R 
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.
Statistics
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PSSM-Id: 320107
View PSSM: cd14976
Aligned: 4 rows
Threshold Bit Score: 353.731
Threshold Setting Gi: 47229369
Created: 23-Sep-2008
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                 #  ##            ######
gi 20455271   82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGwrk-ssINLFVTNLALTDFQFVLTLPFWAVENaldfkWPFGkamCKIVSM 160
gi 38258194   40 LMVALAYGLVGAIGLLGNLAVLWVLSNCARrapgppSDTFVFNLALADLGLALTLPFWAAESaldfhWPFGgalCKMVLT 119
gi 47229369    3 VVVSVVYSVVATAGVLVNALVMFLLYSTHTitt-gtINFFVFNLAVAHLLFSMVLVFWAVEAaldysWPFGlpmCKAVCF 81
gi 313216438  24 NLVGALYMIIFTVGAFGNIIVIYGFKSNKKlrqqseSNKYIWHLAITDLIFVCTLPFFAVDYfyrhvWIFGtywCKVCRY 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         ##  #                                                           # #####        
gi 20455271  161 VTSMNMYASVFFLTAMSVTRYHSVASAlkSHRTRghgrgdccgrslgdscCFSAKALCVWIWALAALASLPSaifstt-- 238
gi 38258194  120 ATVLNVYASIFLITALSVARYWVVAMAagPGTHLs---------------LFWARIATLAVWAAAALVTVPTavfgve-- 182
gi 47229369   82 LTGLNVYSSCFFLAAMSLTRYCYVATAlkAGGSLcs-------------rSSTSWAVTAFIWAAAVVAASPRavfaqlsh 148
gi 313216438 104 VSKVNMYSSIFFLTALSVDRMIAVTRPtsHLWIRk---------------AKGIFATSIAIWCSSLAMAIPEaiystdt- 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                     #  ### ### ##                                      
gi 20455271  239 vkvmgeELCLVRFPdkll----grdrQFWLGLYHSQKVLLGFVLPLGIIILCYLLLVrfiadrraagtkggaavaggrpt 314
gi 38258194  183 gevcgvRLCLLRFPs-----------RYWLGAYQLQRVVLAFMVPLGVITTSYLLLLaflqr-----------------r 234
gi 47229369  149 lgsgndTACTLRFPa----------gTTWLGINQLLRMVLGFLLPYAIITLSYLLLLrflcrhn--------------lr 204
gi 313216438 168 wssvnhTICGMSFPknsssqasvtrwYNLMGMYELTKCIFGFFGPICIILYSYAAILytvqwk----------------l 231
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                #  ## ##  #                  ## ###  #  ##              
gi 20455271  315 gasaRRLSKVTKSVTIVVLSFFLCWLPNQALTTWSILikfnavpf-sqeyflcQVYAFPVSVCLAHSNSCLNPVLYCLVR 393
gi 38258194  235 qrrrQDSRVVARSVRILVASFFLCWFPNHVVTLWGVLvkfdlvpw-nstfytiQTYVFPVTTCLAHSNSCLNPVLYCLLR 313
gi 47229369  205 gsgsRRKANVSRSVAVVVLSFCICWFPYNILSLWGTLiqldivhf-slsffraQTYFFPVANCLAFTSSCFNPVIYCLVR 283
gi 313216438 232 igskDGKSRATKLAFLIVLTFIICWLPFQALSLQSALggfldvmemsdaahafFRKAMPYAIFLAYSNSALNPILYAFTL 311

                 ....*..
Feature 1               
gi 20455271  394 rEFRKAL 400
gi 38258194  314 rEPRQAL 320
gi 47229369  284 rEYRTAL 290
gi 313216438 312 rPFRDGF 318

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