Conserved Protein Domain Family
7tmA_FMRFamide_R-like

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cd14978: 7tmA_FMRFamide_R-like 
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.
Statistics
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PSSM-Id: 320109
View PSSM: cd14978
Aligned: 90 rows
Threshold Bit Score: 115.038
Threshold Setting Gi: 45645182
Created: 23-Sep-2008
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:
  • Comment:based on the structures of some class A family members with bound ligands (peptides or chemicals), agonists, or antagonists
  • Comment:Small-molecule chemical ligands tend to bind deeper within the receptor core, compared to a peptide ligand neurotensin, which binds towards the extracelllular surface of its receptor.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                 #  ##                  
gi 350645541   9 FLNTHIAPFIVILGIIGNVLSIIVLRNRRMks--pVSIYLISLSVFDILLLVCAVVLFFEYPfaeeenssflpymqnsst 86
gi 443704743  18 VVWSIWSPVLLLVGLIGNTLSFVTLARQILrh-rvSTIYFRALCIADSGALLFGLLPIWPLYlagydvt----------- 85
gi 321474903   4 YSYGIALPAICILGILGNVLNLIVLTRPSMrg--pAYVYMRGYAGAALLAIVFALPFSSRILfhneigpwn--------- 72
gi 442616824  61 YCYGLVLPIICAMGIIGNVLNLVVLTRRNMrg--tAYIYMRAYSTAALLAIVFAIPFGIRMLvhkdrgqwe--------- 129
gi 443687456  28 DLFIAVSPIILIVGLVGNILTLVVMNRPSHrp-ssVSIYLSTLAISDSLVLILDFINNWFKMhldikll----------- 95
gi 161082698  60 FVHQYYIPVLCCTGSIGNILSVFVFFRTKLrk-lsSSFYLAALAVSDTCFLAGLFAQWLNFLnvdiy------------- 125
gi 21264552   25 IAYCYVLPCICAIGIVGNITNLMVLASRRLra--vSYMYLRALAVADLLCMLFVLVFVSTEYlakngssin--------- 93
gi 215503901  47 VAYGVVSFVIIALGIVGNLINLVVLTRPNLkg--vTFVYLTWLATSDLLTLVVAVFSMLRLHgiqprty----------- 113
gi 72003596   38 ITYAYIAPFIIIFGIVGDVLTVVTLTHPLLrkssiIYTYLTLLAMTDLLTQFSVIPMIMWLLdiracsk----------- 106
gi 150387823  57 VAHVIVMPIVLSIGMINQCLNVCTLLHIRTs----IFLYLKASAIADILSIVAFIPFLFRHAklidpsw----------- 121
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                          ###### ##  #                                  
gi 350645541  87 edyfstlnklvnktidhtkinnittahriyaliqAHFIYPIALTAQtsTIWITVSLTVERYIAGCYPlhan----vlssV 162
gi 443704743  86 ----------------------------aqhaviCKLRNFLFITFSdaSIWLICAFTLDRLVAVVFPlkrk----syctR 133
gi 321474903  73 --------------------------sfaqaffhAHLELFLGNACLgiGVFMLVALTVERYLAVCRLgrtr-----afaA 121
gi 442616824 130 --------------------------efgpafytAHLELYLGNGCLgvGVMMLLVLTIERYVSVCHPgfa------rpvM 177
gi 443687456  96 ----------------------------vmdesfCKFHRYFFDVVYtlSSWLIVAVSIDRFITVWFPfkak----klcsK 143
gi 161082698 126 -----------------------------nqnyfCQFFTFFSYLASfcSVWFVVAFTVERFIAVIYPlkrq----tmctV 172
gi 21264552   94 -------------------------qyklyqiyqCHLMLTLINWALgaGVYVVVALSLERYISIVFPmhfr----twnsP 144
gi 215503901 114 ----------------------------paafyfAHVEMPLVNALMasSVFIVIAVTVDRYWSVCLPtryk----efhnS 161
gi 72003596  107 ----------------------------ssaffyAHIGFPLANALMgsSVWIVVFLTLSQYMAVCKPfay------glrS 152
gi 150387823 122 ---------------------------elgmfyhAHLELPLINALIsaSALNIVAMTVDRYVSVCHPikffqnnetkpsR 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                      # #####                                   #  ### ### ##           
gi 350645541 163 PKSRLVVCCCMICAIVYNIPRwfeittqsvnttesn-----ysqysiqydwhsifrLVYYTWGYILVMFLLPLIALLVMN 237
gi 443704743 134 RHALIAITVIWAVATLKNVPMlitwgirethnyshh-----vskcgvpepdhafyeEYIRPWLVFTTVTFIPFIFITACN 208
gi 321474903 122 KKTPLVALGLALLAVSLYLPYlfrahvitcsslpdgl---pvyrkrenpsfahstlWAVYLWILEVIFKMAPTLIIVHLN 198
gi 442616824 178 GPPGVVVFLTCLATVIVYLPSifrgelikcilgssdv---yvylrrdntiyqqtifYRVYKIMLEVIFKLVPTLVIGGLN 254
gi 443687456 144 KTAIIVCCVLPLISLACYAHRvpgwhldetgiep----------vcnthpkhrdfqESYGPWLSAVLYSYGPIVMLIVFN 213
gi 161082698 173 RRAKIVLFCLTLVGCLHCLPYiviakpvfmpkln---------tticdlnseykeqLALFNYWDTIVVYAVPFTTIAVLN 243
gi 21264552  145 QRATRAIVIAFLIPAIFYVPYaitrykgkqrfdllqn---vtiysmddhpiyttfyWQIYKWTREAILRFLPIIILTVLN 221
gi 215503901 162 RRAKLAILSAYVAAALLYVPVafqkspvpvwderanr---tqyvpcdnvsvsrhlvFKIYLLVKEVLVRIGPVLVVAVLN 238
gi 72003596  153 RKICYVLFALAYMFNFCIYAPwavkknvhdisdlvpesflvsvcpyvvcdakrpdwFVIYETARELISRIFPFFLVAFLN 232
gi 150387823 175 RRTMLIIVMIYFIALMIYFPSvfqkklgvvtdaltnk---tiytivrnedvealqvFKFYLIVRECICRWGPVLLLVILN 251
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 350645541 238 IRlmyalrrsdfal------------------------------------------------------------------ 251
gi 443704743 209 IIivhhvqrmglsqat---------------------------------------------------------------- 224
gi 321474903 199 CCiivvyrrtcarrrsm--------------------------------------------------------------- 215
gi 442616824 255 MRimmvyrrtcerrrkmvlsrphaqghgh--------------------------------------------------- 283
gi 443687456 214 GLivfrlrkkask------------------------------------------------------------------- 226
gi 161082698 244 TCtgctvwkfatvrrtltmhkmkpqtnsmpsnssnssggassavasyrlsaslkrqkstgthpsgqhnvanrqtddqeqq 323
gi 21264552  222 IQimiafrkrqkmf------------------------------------------------------------------ 235
gi 215503901 239 TTiiltfrklmrkrq----------------------------------------------------------------- 253
gi 72003596  233 IKilityrntkrdrmer--------------------------------------------------------------- 249
gi 150387823 252 MCvvrglrkidkrnwfwrqp------------------------------------------------------------ 271
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                       #  ## ##  #             ## ###  #
gi 350645541 252 ----------------ckplqptqyldtPHNKSITRMIIVVVGVFIACQLPALIFNIYFGivspk-vlpygWCALSELRN 314
gi 443704743 225 ---------------iarvrsitrqsseISVASMSRMCLAVSFTFVVLVSPSIVILVGKPywtkteqseakFHLARSFGN 289
gi 321474903 216 -------------tmpngqqpaddsrryWEEKRLMFLLGSTSILFSVCITPQLVLSLMIHeavl---qsyyFQVFRAVAN 279
gi 442616824 284 -ghghghghghghahghgylkdddprkfAEERRLFLLLGSTSILFLVCVSPMAILHMTIAsevy---psfpFQVFRASAN 359
gi 443687456 227 -----------------kdamtpndkslSQERRITITIVVICVAFILLTLPLALFYIFQFamgefieqrptIALAETIVL 289
gi 161082698 324 qqsqqhqinncqhhceitqkparrkvqnSSQLKVTKMLLIVSTVFVCLNLPSCLLRIEAYwetesarnqnsTIALQYIFH 403
gi 21264552  236 ----------------qqltnkrkeqgtQKDDTLMYMLGGTVLMSLVCNIPAAINLLLIDetlk---krldYQIFRAVAN 296
gi 215503901 254 ---------------qlmnnsnrdtgkfLEEQRLVILLAAIVIMFCVCMTPAAVLTVLIGddke---lnygFQLFRAIAN 315
gi 72003596  250 --------------lansqkkfmfekseKEEKRLFILLFAIVIVFFVCTIPAAPLTILVAdtkn---nnvgFQIFRAVVN 312
gi 150387823 272 ----------sqnsrtetlaqrqlrsprDDRSRISVLLFVTSATFIICNIPASVISFFVRrvsg----slfWQIFRAIAN 337
                        410       420
                 ....*....|....*....|....*
Feature 1          ##                     
gi 350645541 315 FLVVVNSSVNFIVYCVMGakFRRSF 339
gi 443704743 290 LCQYTNNAINFLLYLSSGreFRREL 314
gi 321474903 280 ILEVTNYSFTFYIYCMFSrdFRATL 304
gi 442616824 360 LLELINYSLTFYIYCLFSedFRNTL 384
gi 443687456 290 ILGLSNHAVNFFLYVMSSpkFRADV 314
gi 161082698 404 AFFITNFGINFVLYCVSGqnFRKAV 428
gi 21264552  297 ILEITNHASQFYVFCACStdYRTTF 321
gi 215503901 316 DMEMANFAMNFYVYCLCSseIRGTF 340
gi 72003596  313 LLEFTKFAMNFYFYCLINpdIRSIC 337
gi 150387823 338 LLQVTSYLYNFYLYALCSseYRHAF 362

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