Conserved Protein Domain Family
7tmA_Glycoprotein_LRR_R-like
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cd14980: 7tmA_Glycoprotein_LRR_R-like 
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.
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Statistics
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PSSM-Id: 320111
Aligned: 24 rows
Threshold Bit Score: 247.539
Created: 23-Sep-2008
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:
  • Comment:based on the structures of some class A family members with bound ligands (peptides or chemicals), agonists, or antagonists
  • Comment:Small-molecule chemical ligands tend to bind deeper within the receptor core, compared to a peptide ligand neurotensin, which binds towards the extracellular surface of its receptor.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                               #  ##                 
P79763    363 NVLRVLIWFINILAITGNTTVLIILISSQYkl---tvPRFLMCNLAFADLCIGIYLLFIASVDiqtksryynyaidWQTG 439 chicken
Q9HBX9    406 IIQRVFVWVVSAVTCFGNIFVICMRPYIRSen---klYAMSIISLCCADCLMGIYLFVIGGFDlkfrgeynkhaqlWMES 482 human
EDV29449  246 VSLRIFVWCTSCMIIIGNILTLYVNKTLEQcrn--pvPKLLVNNLASADLLMGIYLLIIGFADgilhnryasnleyWLQS 323 Trichoplax adhaerens
EDV19931   33 PSLRIFTWIVSILAVIGNALVILLYRRDSKagh--pvPKLVVSHLAFADFLMGLYLLIIAIADmltrhdygiysvyWNKH 110 Trichoplax adhaerens
EDV29447  426 RSLQIFVWIVGILALIGNTSVIIMHWIWRRkfhrhlvPTFLISNLAFTDLLTGFYLIIIAVADqiyhhnyaqysefWLRH 505 Trichoplax adhaerens
EDV20492   26 TLLRVFIWMIGVISAIGNFIAIIWHTKSMTkef--qvVKTLLINLSIADFTMGIYLINIASANiyfagiyseyletWLRS 103 Trichoplax adhaerens
EDV21082   54 NILRIIIWILGNLAVIENAISIVWHSPFRKdgk--cvPKVLIVNLSIADFLMGVYLIIVASANtfyaqrysefvevWLRS 131 Trichoplax adhaerens
EDV18981   42 DLLRVFIWVIGIISVVGNTVSIRWHSQKKSskk-lgiVEMLLINLSAADFIMGIYLIIIASANvyyanryyeifqeWLRS 120 Trichoplax adhaerens
EDV19917   46 GVLRVFIWLIGVLSIIGNIVSIIWHTNGKNkdy--iiVRSLIINLSTADLLMGIYLTTIASANiyfsgvyaeyhevWLRS 123 Trichoplax adhaerens
EDV20289   29 DVLRIFVWIIGSLSIVGNIISIVWHVKSFVknn--mvVQTLLINLSFADLIMGIYLITIAVTDiyyfgiyaqyletWLHS 106 Trichoplax adhaerens

Feature 1       ###### ##  #                                            # #####               
P79763    440 agCNAAGFFTVFASELSVYTLTVITLERWHTITYAMqlnrkvrLRHAVIIMVFGWMFAFTVALLPIFGissy-------m 512 chicken
Q9HBX9    483 thCQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFrcv-rpgKCRTITVLILIWITGFIVAFIPLSNkeffkn---yyg 558 human
EDV29449  324 pmCALACFLTAISSVMSVVIMLIITVDRFINIVFVMpkf-kitKKCATITMITSWSLCIVCVGIPAIAsinqqsdnrfye 402 Trichoplax adhaerens
EDV19931  111 pmCLLASFLMSLSSFMSVFMMLLIGIDRYICIVYPFsnk-rldMATTKKTLGLAWVISIGYIAGPIVYsinkpytqtvyg 189 Trichoplax adhaerens
EDV29447  506 pfCVFACFLTCVSSIMSVLMMFVITIDRYICVVYPLsgk-rltIKSASAIVTFFWLVSISYVAFPLMFgfgksaddriyq 584 Trichoplax adhaerens
EDV20492  104 pfCSIASSLITLSSFMSTVILFLISLDRYWGLVYMFdny-rlsYRFVVISLSLSWVLSIIYIGLPVIYsinqpsqyrfhg 182 Trichoplax adhaerens
EDV21082  132 paCLISCFLISLSCLTSTIILLLITVDRFLYLVFPFtsy-rlrYSLLLWVLIAVWSISIAFIAVPIASsfgqssyyrlyg 210 Trichoplax adhaerens
EDV18981  121 vpCLTASFCISLSSLMSTFVLFLITLDRYLHLVYPFqny-rlsTKTTILALVVLWLISIAFVGLPILYsinqpsinrlys 199 Trichoplax adhaerens
EDV19917  124 tvCSICSFLVSISTFVSTLVIFLITLDRYLYLVYPFqny-rlsYRQIFNIFLIVWAISAVFTGLPIIYgfnqtpnnrlhs 202 Trichoplax adhaerens
EDV20289  107 viCVMASFLVAISSLMSTFILFLITLDRYLFLVYPFeny-rlsYKLITLVLIVLWTVSATFTALPLVYsynqpasyrlyg 185 Trichoplax adhaerens

Feature 1                      #  ### ### ##                                                  
P79763    513 kvsICLPmhi----etpFSQAYVIFLLVLNVLAFVIICICYICIYFTvrnpn------vissNSDTKIAKRMAILIFTDF 582 chicken
Q9HBX9    559 tngVCFPlhsedtesigAQIYSVAIFLGINLAAFIIIVFSYGSMFYSvhqsaitateirnqvKKEMILAKRFFFIVFTDA 638 human
EDV29449  403 yssVCMPsni----nnpYFANWIFVVLGMSFLIWIAILIMYGLTLASlrkarlk-vkkksdfNYEKRVAIRMLVILTTDL 477 Trichoplax adhaerens
EDV19931  190 dspVCVPinl----shkFFYLWLSSYIFLTFLMWIIVTILYIRLFIKvkqsgrs-irrnqktNQEHRMAIRLFLICITDI 264 Trichoplax adhaerens
EDV29447  585 yssVCLPmni----hnsFFRIWILTSIAITVLIWIIVSILYLAMFISiqrtrmavencrnirEDDKRIAGRMLIILLANL 660 Trichoplax adhaerens
EDV20492  183 tngACIPgnl----sntYFLIWLIFYCAFTFVIWITISMMYIAMIVTltrirkq--anrqisSVEKIIQAKMIAIVITDL 256 Trichoplax adhaerens
EDV21082  211 tnsACLPgnv----dnyWYLTWLILYCGFTFAVWIIIAVLYILIIKSltqsrrk--tkqslsNIDKIATAKMVTVVITDL 284 Trichoplax adhaerens
EDV18981  200 snsACLPgnf----nnpYLLTWLLCYAGLTLIVWIFIAIMYAAILSTlansrke--ahrrlsKNDKIIRAKLITIVATDL 273 Trichoplax adhaerens
EDV19917  203 vngACLPgni----snpYLLLWLLCYCGVTFLAWAIISIMYSGIIITlaksrre--anvqisRLDKIIVAKMITIVATDL 276 Trichoplax adhaerens
EDV20289  186 tnsACLPgnt----dniYYLSWLLTYCGTTLLTWIFIAIMYIIILVYltksrkq--akreisKFEKIVRAKMITIVITDL 259 Trichoplax adhaerens

Feature 1       #  ## ##  #                      ## ###  #  ##                         
P79763    583 LCMAPISFFAISAslrv--------------plitVSKSKILLVLFYPINSCANPFLYAIFTk----tFRRDF 637 chicken
Q9HBX9    639 LCWIPIFVVKFLSllqv---------------eipGTITSWVVIFILPINSALNPILYTLTTr----pFKEMI 692 human
EDV29449  478 ATWMPFYVLLISGvfgn---------------eidIHALPFIAILVMPMNSCINPFLYTLSTkkvlqhFRFKF 535 Trichoplax adhaerens
EDV19931  265 VCWLPFYFVFWLSviqirrgeahsylnsgfsvilrFTILPYVVVFALPINSAINPFLYTFTSs----nFTDRL 333 Trichoplax adhaerens
EDV29447  661 ACWMPFYIVMVRSmlds---------------evqIYTLPFIAVFVLPLNSSINPYLYTFSGst---sMTRSQ 715 Trichoplax adhaerens
EDV20492  257 ICWMPLYIVLLRFlfgy---------------gldTHSLPFIAVLSLPVNSCINPIFYTIFTr----tFLNKA 310 Trichoplax adhaerens
EDV21082  285 ICWLPFYVIITRVllgy---------------gldIHTLPFIAVLALPLNSCINPIIYTIFTk----kFTNYV 338 Trichoplax adhaerens
EDV18981  274 ICWLPLYIVLIRGfgy----------------gldTHSLPFIAVLSLPLNSCINPIIYTLFTt----tFIDYI 326 Trichoplax adhaerens
EDV19917  277 ICWLPFYAILIIGlins---------------eldTHVLPFIAVLSLPLNSCINPIIYTMFTq----tFLDRS 330 Trichoplax adhaerens
EDV20289  260 ICWMPLYVVLIQAtieq---------------eldTHVLPFIAVLSLPLNSCINPIIYTIYTt----tFVNNA 313 Trichoplax adhaerens

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