Conserved Protein Domain Family
7tmA_Prostanoid_R

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cd14981: 7tmA_Prostanoid_R 
G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors
Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.
Statistics
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PSSM-Id: 320112
View PSSM: cd14981
Aligned: 24 rows
Threshold Bit Score: 220.58
Threshold Setting Gi: 83287886
Created: 17-Nov-2008
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:
  • Comment:based on the structures of some class A family members with bound ligands (peptides or chemicals), agonists, or antagonists
  • Comment:Small-molecule chemical ligands tend to bind deeper within the receptor core, compared to a peptide ligand neurotensin, which binds towards the extracelllular surface of its receptor.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                     #  ##              
gi 1172071    49 SVSVAFPITMLLTGFVGNALAMLLVSRSYRrreskrkksFLLCIGWLALTDLVGQLLTTPVVIVVYlskqrwehidpsgr 128
gi 405952363  17 PNFTVSFGFYIGLGVLGNLVAFILLLKQSKfhk---wkvFYRLVLMLVCVDLAGIVIFSCISIIESpltkw----adsgs 89
gi 405962648  41 YENIAPVTLLFFFGVAGNIIAVLVLFCSSKthk---wrpFYKLVCGLAISDGGGILASYPIAEYRYisnfey---vfpkh 114
gi 405962646  21 VQDSVPVILLFLFGVFGNLAALIVLCFRSKihe---wrpFYRFVLGLAITDGGGLLISIPISEYQYlsrfkd---qlprp 94
gi 405972512  22 SGSSMPAALQFVFGVLGILIAIIALFTARKkhk---wrpFYRLVLGLALTDGGGILLIFPTIFLRYasnfty---dfpkp 95
gi 405975597  21 TMSPVESAVMFTLGVGGNILALVMLVRNAAhhk---wkiFYRLVGALASSDLFGILSTSPVAFAVYdnhfvw---pggqp 94
gi 405962645  20 WPSPAPASLLLVFGVVGNILALVILFCSARshk---wrpFYRFVCGLAITDGGGVFLSYPLVMVRYasqfqy---dypqp 93
gi 405956048  11 WESPVPPVLQFVFGVLGNFMALLILVCNSPshr---whpFYKLVAGLALTDGGGILLLYPPILTRYatnftf---nlgsf 84
gi 405969962   8 KGYVGMIIAMFLLALVFNISALIMIVRSSKshk---wsaFYRLMVSLNITDLVGSVTCFPVLLATYannvqw---qggqp 81
gi 405976790  25 FESIVPPSLQYGFGVFGNLIAIILLFRSSGqhk---wkpFYRLVGGLAITDFCGIALVYPAVMIRYisgftf---dfpke 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         ###### ##  #                                             # #####               
gi 1172071   129 LCTFFGLTMTVFGLSSLFIASAMAVERALAIRaphwYASHMk-TRATRAVLLGVWLAVLAFALLPVLGvgqytvqWPGTW 207
gi 405952363  90 LCKVESILISFISLTNLFVVTFIAIERFLALWhpyfYSSVKg-HPLAMLSPVAIVIVTAVLASLALTQsnf-vkiYPCNF 167
gi 405962648 115 LCDYLGFVFMFTLMSSAMIVCCMSIDRFFAIFfpflYNTPTk-NRRTWIMLGIVWILAGVLSSLHLYGlgasmnyYPGSW 193
gi 405962646  95 VCEYLAFIYMFTLLSSAMIVCCMSVDRFLATFfplyYNSTTk-GRRANITLTLLWITSALLCILHVFGlgsakifYPGSW 173
gi 405972512  96 LCDYSSFMFIFTLTSSAMIVCALSFDRFMAILypfrYNMIGk-KYRANIMLGLVWITCAFLASLPLMGlgsslsyYPGSW 174
gi 405975597  95 VCDYLSFMLIFASMGTLTIVSAMSLDRYLAVWypffYNISQk-KRRVHVMLVGVWVFAALIASMPLMSfgrnirhFPCTW 173
gi 405962645  94 MCDYMAFILMFTILASALIVCAMSLDRFLAILyphfYNKPTk-NRRAILMIAGIWIFSAVMSSLHLMAghkslsfFPGSW 172
gi 405956048  85 LCGYTSFLASFTILSSALIVCAMSIDRCVAVYrpfyYKSEYgdRRRVVAVIGAIWAVGGLVSSLHLAGlgsvykfYPGSW 164
gi 405969962  82 VCDYTGYMISFVFLSSASIIGAMSTERFVGVWfpffYNKSGakERRTNIILGGIWTTTACIALLPIIGfgeyvlqYPGTW 161
gi 405976790  99 LCGFVSFCFSFSFLSSALIVSAMSFDRFLAVTcpilYRESQ--VKRTNVILIVIWIFSTCISSLNLVGigsvknfYPGSW 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                          #  ### ### ##                                                 
gi 1172071   208 CFIstgrggngtssshnwGNLFFASAFAFLGLLALTVTFSCNLATIKALvsrcrakat----asqssaqwgRITTETAIQ 283
gi 405952363 168 CFIniys--------knyADYIFAFVYIIIGLVLVAVAIVMNILVAIALsrgqrgysrqr-esriyitndkRDYCGMLFQ 238
gi 405962648 194 CFLdfid-------msvtSKVIYSYIYATTGAIVVIMTVFINFLVIIFFirnkfsk---------tatktkRNDLPVVLF 257
gi 405962646 174 CFLnfid-------tedtGNAVYAYMYAITGVLIVTLTLLLNLTVIVYFiykrltrn------fsasptqsWCDVHVIVF 240
gi 405972512 175 CFLnfvs--------lstLDRVNSFIYSLIGLFILLTTFIFNLCVVITLcrnlatnk------risqksrkKSDIFNVVF 240
gi 405975597 174 CFFdyyg--------tymLDRAFSILYATLGILNTIVSSTFNCLVLYAVcrgtintrrlsirsargkkrekKNEIFILIF 245
gi 405962645 173 CFLdfv----------hsDTKAFAFLYSVTGILVLGTTAALNITVIFNVcrniqq----------kkkkpkKKDIYIIAF 232
gi 405956048 165 CFLnfis--------gttLERVNSLIYSGLGILVLLITVTLNFSVIVATlhkkhr----------ahlgrlRKDVYNIVF 226
gi 405969962 162 CFYnfra--------knlADKVYAYLYSVIWILIIFCTVLFNLLVIVKLvmrrvsasd----kkkqnskakRNEIYSIVL 229
gi 405976790 177 CFLdfan--------kgkLERINTYIYSITGFLILSTTVFLNIAVVYSVnrkpkfl--------tsdkrkkRNDIFIIVF 240
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
Feature 1                   #  ## ##  #                  ## ###  #  ##                      
gi 1172071   284 LMGIMCVLSVCWSPLLIMMLKMifnqtsvehckthtekqkECNFFLIAVRLASLNQILDPWVYLLLRkiLLRKFC 358
gi 405952363 239 IGAAIAEVAVCWIPIMIRMLITmtgde---------tsekDIKNNYLFFRFASWALVVDPWIYVLLRreIIINIC 304
gi 405962648 258 LLAIVVLFTSCWAPLMVNVFQHatfs-----------vsgQGKTELTFLRMAVTNSVIDPWLYILFRkeNLVMLV 321
gi 405962646 241 LISIVTVFTSCWSPLIVNILQHvsga-----------tsgVGETELLLVRLSITNSVIDPWIYILFRkeVVAVAV 304
gi 405972512 241 LLVLVLVFATCWTPLMIVIFGHaaal-----------asdNGKLELFVVRLAVTNSIVDPWIYILFRkeNIILIT 304
gi 405975597 246 LIAILIVHSVCWMPLMIRVLVNtsg------------arpNYKADLLALRMASWNQILDPWLYILLRkeMLTRIY 308
gi 405962645 233 LLLIVILFSSCITPLLINIFGHaigt-----------lsgNGQFELVALRISVTNSIVDPWIYIVFRkdTFDFFQ 296
gi 405956048 227 LSAIVLISSICWAPLMWRIMSVscdl-----------stpNQGTELLSLRLAVSGSIVDPWVYILLRkeTLSYIH 290
gi 405969962 230 LVVIVIVTATCGVPLAIRAIVNesg------------sekNNNADLHASRMATFNMILDPLVYIFFRreNLEWLF 292
gi 405976790 241 LFSIVTVFSICWVPLMVRMLINasas-----------dpkNGPDELLAVRMTISNAIVDPWIYIILRkeNLVKMS 304

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