Conserved Protein Domain Family
7tmA_ACKR3_CXCR7

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cd14987: 7tmA_ACKR3_CXCR7 
CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors
ACKR3, also known as CXCR7, is an atypical chemokine receptor for CXCL12 and CXCR11. Unlike the classical chemokine receptors, ACKR3 contains a DRYLSIT-sequence instead of the conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. Thus, ACKR3 does not activate classical GPCR signaling, instead induces beta-arrestin recruitment which is leading to ligand internalization and MAP-kinase activation. It is acting as a scavenger for CXCL12 and, to a lesser degree, for CXCL11. ACKR3 is highly expressed by blood vascular endothelial cells in brain, in numerous embryonic and neonatal tissues, in inflamed tissues and in a variety of cancers such as lymphomas, sarcomas, prostate and breast cancers, and gliomas. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.
Statistics
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PSSM-Id: 320118
View PSSM: cd14987
Aligned: 7 rows
Threshold Bit Score: 452.29
Threshold Setting Gi: 632975154
Created: 4-Jan-2014
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                               #  ##            ###### #
gi 132206     45 YTLSFIYIFIFVIGMIANSVVVWVNIQAKTtgydTHCYILNLAIADLWVVVTIPVWVVSLvqhnqWPMGeltCKITHLIF 124
gi 32698457   49 YTLAIVYIFIFVMGLLANSMVIWLNLQSKTtgyeTHLYIFNLAIADLCVLLTLPVWVVSLvqhnqWPMGemtCKITHLVF 128
gi 115502380  45 YTLSFIYIFIFVIGMIANSVVVWVNIQAKTtgydTHCYILNLAIADLWVVLTIPVWVVSLvqhnqWPMGeltCKVTHLIF 124
gi 134085621  49 YTLSFFCIFIFVIGLVANSVVVWVNLQAKMtgyeTHLYIFNLAVADLCVVITLPVWVVSLvqhnqWHMGeitCKITHLIF 128
gi 158254308  44 YALSVLYIFLFIIGLAANALVVWVNVRAERtryeTHLYILNLAIADLCVVATLPVSISSLlqlghWPFGgaiCKITHLIF 123
gi 556982281  49 HTISYFYIFIFVIGLLANSVVVWVNLRTKRnhfeTHLYVLNLAVADLCVVITLPIWVASLvnhgqWHMGgfmCKITHLIF 128
gi 632975154  51 YTMSFFYALIFIVGLVANVVVVYVNLKTKRtqyeTHLYILNLAIADLCMVATLPIWLPSLvqhgsWPFGefmCRLTHLVF 130
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #                                             # #####                        
gi 132206    125 SINLFGSIFFLTCMSVDRYLSITyfasTSSRRkk-vVRRAVCVLVWLLAFCVSLPDTYYlktvtsasnnetYCRSFYPeh 203
gi 32698457  129 SINLYSSIFFLTCMSVDRYLCVSlngtAGQRRrk-iVRRLVCVLVWLVAFVFSLPDTYYlktvsspvtnetYCRSMYPee 207
gi 115502380 125 SINLFGSIFFLTCMSVDRYLSITyftnTPSSRkk-mVRRVVCILVWLLAFCVSLPDTYYlktvtsasnnetYCRSFYPeh 203
gi 134085621 129 SINLYGSIFFLACMSVDRYLSVAyftnSSNRKkk-iVRRCICILVWLLAFSASLPDTYFlktvs--tsnetYCRPAYPee 205
gi 158254308 124 SVNLFSSIFFLTCMSVDRYLSVKlfgdTPSQRkr-rTRQIICVGVWLLALIAALPEIYFlqaeksdhsdaiVCKAVYPve 202
gi 556982281 129 SVNLFGSIFFLTCMSVDRYVSVTlf-rDSNNRnkriIRRLICIFMWLFAFGASIPDTYFlqiiaepftndvYCRVTYPle 207
gi 632975154 131 SVNLFGSIFFLTCMSVDRYISVVrvgeSVDRRkg-vIRKIIIVYVWIFALVVSFPDILFlktvtlpsngetYCYPSYPee 209
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1             #  ### ### ##                                               #  ## ##  #    
gi 132206    204 svkeWLISMELVSVVLGFAIPFCVIAVFYCLLARAisa----ssDQEKQSSRKIIFSYVVVFLVCWLPYHVVVLLDifsi 279
gi 32698457  208 tfkeWLLGMEIVSIMLGFVIPFPIIAIFYCLLACTlsssssssgDQERRISGRLIVSYVVVFMVCWLPYHAMVILDvmsf 287
gi 115502380 204 sikeWLIGMELVSVVLGFAVPFSIIAVFYFLLARAisa----ssDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDifsi 279
gi 134085621 206 sfkeWLIGMELISVVLGFLIPFPVIALFYFLLAKTisa----ssDQERKSSGKIIFSYVVVFLVCWLPYHTTVLLDifys 281
gi 158254308 203 smkeWTVGIQMSFFMLGFAIPFPVIAVFYILLANTihp----svDQERRISRHLIFTYIVVFLVCWLPYHGALLLDtlaf 278
gi 556982281 208 yfweWLVGMELLCIVLGFVIPFPIIAIFYILLASAita----ssDQERKTSRKIIFSYVIVFLVCWLPYHTVLLIEaltm 283
gi 632975154 210 nfrkWMAGMEMVYIIIGFVIPFPIITVSYFLLARAiss----tsDQENKNSRNIIFVYVIIFLICWLPYHTVLFIDvlwf 285
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
Feature 1                     ## ###  #  ##                     
gi 132206    280 lhyipftCQLENFLFTALHVTQCLSLVHCCVNPVLYSFINrnYRYEL 326
gi 32698457  288 lqlipfsCFLDNFFYAALHITQCYSLLHCCINPILYSFIHrnYRYEI 334
gi 115502380 280 lhyipftCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINrnYRYEL 326
gi 134085621 282 lhfipfsCQMENFLYATLHITQCFSLVHCCVNPILYSFINrnYRYEL 328
gi 158254308 279 lnvlpfnCTLENALYAALHLTQCFSLFHCCANPIIYNFINknYRYDL 325
gi 556982281 284 lqvlpfsCDLEDFLYVAIHVTQCFSLIHCCINPILYNFINrnYRYDL 330
gi 632975154 286 mnlisfsCELESFMYISLHLTQCFSMVHCCANPILYSFINknYRYRL 332

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