2KS9


Conserved Protein Domain Family
7tmA_TACR_family

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cd14992: 7tmA_TACR_family 
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tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.
Statistics
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PSSM-Id: 320123
View PSSM: cd14992
Aligned: 5 rows
Threshold Bit Score: 347.498
Threshold Setting Gi: 310942510
Created: 30-Sep-2008
Updated: 26-Jul-2017
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 41 residues -Click on image for an interactive view with Cn3D
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
2KS9_A        33 VLWAAAYTVIVVTSVVGNVVVMWIILAHKRmr-------------------------------tvTNYFLVNLAFAEASM 81
gi 222876512  67 IVIGVALVGIMLVCGIGNFIFIAALARYKKlr-------------------------------nlTNLLIANLAISDFIV 115
gi 405951227  26 SILMVLYSVIIFVSLVGNMLVLITVCGNRNmr-------------------------------svTNVFILSLSVSDLLL 74
gi 443682732  18 NILTVLHCIVITFAVVGNIGVIVVFAKNKSfr-------------------------------gaVTIPILSLAIGNLLM 66
gi 360044526 105 PHSENYLQSFKNRHVDGNYSSSASDYDHNNllkknldnsiekapkhlhhimrntcqkqtfymngaFNYYLASLGISDLFM 184
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1               #  ##                ###### ##  #                                        
2KS9_A        82 AAFNTVVNFTYAvh--neWYYGlf---yCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPlqpr-----lsaTATKVVI 151
gi 222876512 116 AIVCCPFEMDYYvvrqlsWEHGhv---lCASVNYLRTVSLYVSTNALLAIAVDRYLAIVHPlkpr-----mnyQTATILI 187
gi 405951227  75 ALIATPINMGNVms--tyWKYGaf---aCKIVPCITTFCVACSSLTLCCIAFERFYAIVYPlkvkf---fqasTRLVPLL 146
gi 443682732  67 ALLCLPFSLILVls--rsLEMNsfsefvCKLVPYMETTTIVSNALTMGGIAMERYFATLHPlksrs---iqstTKTVLIL 141
gi 360044526 185 GLFCIPFTFTQIyl--hhWPFPdl---mCPIVVYVQLVMVTASSLTNTVISLNRLFGIISPfrfdhwpsrhqkSLTICII 259
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1               # #####                                       #  ### ### ##              
2KS9_A       152 CVIWVLALLLAFPQGYYsttetmpsrvvc------------miewpehpnkiyEKVYHICVTVLIYFLPLLVIGYAYTVV 219
gi 222876512 188 ALVWIVSILVAIPSAYFatetvlfivknqek--------ifcgqiwpvdqqmyYKSYFLFIFGIEFVAPVITMTLCYARI 259
gi 405951227 147 ITVWVTSLISGTPQVFYfklikardvcgkvv--------ndvctlplitsktmEFFQLWLPFVVLFVTPLLVMTILYSII 218
gi 443682732 142 TTIWMVAVCLAIPNLLWhslepilsadilng---------pyqgfcspsnhtaMTVYRLLILVGIFGLSFIAITVAYVQI 212
gi 360044526 260 ISIWAISFSGSTVQLFAtrtqrqgqntnpleqkegysagrklcqeswdgddykRSIYTVVLFLVIYIIPLGIQTSTYGYI 339
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                  #  ## ##  #             ## ###  #  ## 
2KS9_A       220 GITLwaseipgds-sdryheqvSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPyinpdl--ylkkfIQQVYLAIMWLAMS 296
gi 222876512 260 SRELwfktvpgfq-teqirkrlRCRRKTVMVLMCILTAYVLCWAPFYGFTIVRdffpti-fvkekhYLTAFYIVECIAMS 337
gi 405951227 219 IVKLwgrrqigismkasdsyrlKQKKRAIKMLVTVVVLFIICWLPIQTFNAVGekasn---mtpvaTLQWKAFLKCLALS 295
gi 443682732 213 NRHLnkrkspgnsqcpvellhmKTSRRVISMLVAVQVLFFICWAPFLLFQAIApvlkl---eitpgNLNLYYFLHWWAAC 289
gi 360044526 340 SFRLwnrktpgesikgvedmriKEKKRIIKMLAFIVAMFGICWLPSHLFFLLQdfstlfrnmpehtTRLVYGMCHWIAMS 419
                        330       340
                 ....*....|....*....|
Feature 1                            
2KS9_A       297 STMYNPIIYCCLNdrFRLGF 316
gi 222876512 338 NSMINTMCFVTVKnnTMKYF 357
gi 405951227 296 SSCYNPIVYAFMNenFRKNF 315
gi 443682732 290 NCCQNPIVYTLLHpkFRRNF 309
gi 360044526 420 NSFVNPIIYLIMSrsFRSIR 439

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