Conserved Protein Domain Family
7tmA_UII-R

?
cd14999: 7tmA_UII-R 
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.
Statistics
?
PSSM-Id: 320130
View PSSM: cd14999
Aligned: 9 rows
Threshold Bit Score: 354.055
Threshold Setting Gi: 229290361
Created: 6-Dec-2013
Updated: 26-Jul-2017
Structure
?
Aligned Rows:
  next features
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 8928474    53 TIGTLLSAMGVVGVVGNAYTLVVTCRSLRav------------------------------------------------- 83
gi 402795973  30 SISAVLSIMCVVGVAGNIYTLVVMCQSMKsa------------------------------------------------- 60
gi 229290361  42 FIAVFFTLICLMGVVGNALCFYVLCLKSSprstitvyilslatadtgkapgfnkllvsirqtqvrpltalcfyvlclkss 121
gi 224814380  27 TFGTLLSVVYIIGVSGNVYTLVVMCHSIRfa------------------------------------------------- 57
gi 229290375  36 ALPVVLGTVFAVGVAGNLVTILWIALRGQpq------------------------------------------------- 66
gi 449283113  56 TIGTILSLMCVIGVTGNVYTLLVMCHYLRss------------------------------------------------- 86
gi 47217304   41 LLGAMLMIMCAMGVAGNTYTLVITRSAALrrt------------------------------------------------ 72
gi 557002045  40 SIGTILSFMCITGVIGNVYTLVVMCHSMRsa------------------------------------------------- 70
gi 632943687  40 AIGTVLSAMLVTGVTGNVHTLVMMCHSMRst------------------------------------------------- 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                 #  ##            ###### ##  #                          
gi 8928474    84 --asMYVYVVNLALADLLYLLSIPFIVATYvt-keWHFGDVGCRVLFGLDFLTMHASIFTLTVMSSERYAAVLrpldt-v 159
gi 402795973  61 --asMYIYIINLALADLLYLLTIPFIVGTYfi-qeWYFGDIGCRILFSLDFLTMHASIFTLTIMSTERYFAVLkpldt-v 136
gi 229290361 122 prstITVYILSLATADTVYILASPFYASTYft-nlWYFGDVGCRLIAAVDVLTLNAATFTLTVMCLERYLAVVdpikslk 200
gi 224814380  58 --tsMYISIINLAVADLLYLSTIPFVVSTYfl-kdWYFGDVGCRILLSLDLLTMHASIFTLTVMCTERYLAVTkpldt-v 133
gi 229290375  67 --ntMRTYVLSLSAADLAYLLGGPFYLSSFmlqpkWIYGEFGCRLIVSLDILTLLASILTLTVTSVDRFLAVVypiktlg 144
gi 449283113  87 --asMYIYIINLALADLLYLLTIPFIVGTYfi-qkWYFGDIGCRILFSLDFLTMHASIFTLTVMSTERYFAVLkpldt-v 162
gi 47217304   73 --gsMYVYIVNLALADLLYLSTIPFVVCTYfa-hdWLFGEVGCRILLSLDLLTMHASVFILVAMSLERYRAVArpfsa-h 148
gi 557002045  71 --asMYIYIINLALADLLYLLTIPFIVCTYfi-kgWYFGDVGCRILFSLDFLTMHASIFTLTVMSTERYFAVLkpldt-v 146
gi 632943687  71 --asMYVYITSLALADLLYLCTIPFVVCTYfa-kgWYFGDLGCRLLFSVDLLTMHASIFTLTVMSTERYLAVVrpldt-v 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                          # #####                                        #  ### ### ##  
gi 8928474   160 qrpKGYRKLLALGTWLLALLLTLPVMLAmrlvrrgpks-----------------lclpawgpraHRAYLTLLFATSIAG 222
gi 402795973 137 krsKSYRKCIAVVVWLVSFLITLPMLIMiklvhkdnks-----------------iclptwskisYKVYLTVLFSTSIVG 199
gi 229290361 201 crsVSLSRVLSGVIWVLALGLSLPMALStelqegydvfgqgssdcwqgdcpsprrcllkfrseqeTKIYFTTLFIVAFVI 280
gi 224814380 134 rrsKSYRKALAWGVWLLSLFLTVPMMIMvaqttkntpdggv------------krmcaptwapvaYKVYVTVLFGTSIMA 201
gi 229290375 145 crsVNSARLSVVLVWLISLILSLPIAVFtrmdtvelpggas-----------ietcivdwpsensKRAYMTATFVLAFPI 213
gi 449283113 163 krsKSYRKAIAVVIWLVSLLLTLPMLIMiqlvqrdnks-----------------iclptwsktsYKVYLTILFGTSIVG 225
gi 47217304  149 kssTRRRRLAAGIIWGVAVALTLPMMVMiqlrtgkptaags-----------gkricfptwtpeaFRVYITLLFLTSVLV 217
gi 557002045 147 krsKSYRKAIAIIIWLASFLLTLPMIIMiqlvpvrdks-----------------iclptwsklsYKIYLTLLFSTSMVA 209
gi 632943687 147 krpKGYRKAIAGLLWLCSLLLATPMIIIiklqrvqdki-----------------iclpawslenNKIYLSVLFSTSILA 209
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                             #  ## ##  #                
gi 8928474   223 PGLLIGLLYARLARAyrrsqra-----sfkrarRPGARALRLVLGIVLLFWACFLPFWLWQLLAqyhqap---------- 287
gi 402795973 200 PGLIIGYLYIRLARTywlsqta----sfkqtkrLPNQKVLYLIFTIVLVFWACFLPFWIWQLLTqyyesl---------- 265
gi 229290361 281 PGVVLCAFYLRMLCKywlpagrpi-gevtsratESRKKVAKMVSLILVVFWLCYLPFCTKFCTVlhvfftvlhvfcavlq 359
gi 224814380 202 PGLIIGYLYVKLARTylesqrns--visrgakrSPKQKVLIMIFTIVLAFWACFLPFWIWQLLPlyhtkpl--------- 270
gi 229290375 214 PLLVVSVCYGRMVTKlctavapa---snssksnKDKRRVAKMVLAVTVMFYICWLPFGVLQLLYyhsal----------- 279
gi 449283113 226 PGVIIGYLYIRLAKIywvsqta----sfkqtkrLPNQKVLYLIFTIVLVFWACFLPFWIWQLLFqyyesl---------- 291
gi 47217304  218 PGLVIVALYVCLARRywavqaslggsgrsgrrrGLKQKVVSMIFSIVVAYWACFLPFWGWQLAKlfspeal--------- 288
gi 557002045 210 PGVIIGYLYIRLARTywlsqta----tfkqtkrLPNQKVLYLILTIVLVFWACFLPFWIWQLIDqysdsf---------- 275
gi 632943687 210 PGIVIGYLYIRLARTywvsqata--lnnnqtkrSPNHKVLYMIFTIVLVFWACFLPFWVWQLIQlyhppl---------- 277
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
Feature 1                                                 ## ###  #  ##                     
gi 8928474   288 ------------------------------------laprtARIVNYLTTCLTYGNSCANPFLYTLLTrNYRDHL 326
gi 402795973 266 -----------------------------------pvspkaTKNINYLTTCLTYSNSCINPFLYTLLTkNYKEYL 305
gi 229290361 360 dgvpdpggvlavlpavldpvrclmfhspetirsaasaprlsTTSGRFVLQNLSYINACANPFLYTLLSdKYKAIL 434
gi 224814380 271 -----------------------------------slashtHTCINYLVASLTYSNSCINPFLYTLLTkNYREYL 310
gi 229290375 280 ------------------------------------padrsILYVQICLVGLTYLNSSAHPIIYLCVReRKKKKS 318
gi 449283113 292 -----------------------------------plspkvMKNINYLTTCLTYSNSCINPFLYTLLTkNYREYL 331
gi 47217304  289 ----------------------------------rtfspatHNYVNFFVTCLTYGNSCINPFLYTLLTrNYKDYL 329
gi 557002045 276 -----------------------------------pvssktRRNIFYLTTCLTYSNSCINPFLYTLLTkNYKEYL 315
gi 632943687 278 -----------------------------------smsqrtQGHINYLMTCLTYSNSCINPFLYTLLTkNYKEYL 317

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap