Conserved Protein Domain Family
7tmA_BNGR-A34-like

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cd15000: 7tmA_BNGR-A34-like 
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.
Statistics
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PSSM-Id: 320131
View PSSM: cd15000
Aligned: 6 rows
Threshold Bit Score: 437.627
Threshold Setting Gi: 195947038
Created: 6-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                               #  ##           ###### ##
gi 195947038  48 IKSSMMILVGVSGIFLNCVILTILIRNKWlwspSNCLIGNMALIDFLLLFFCPWFMLVRDffqnYVLKTFGCRFEGFLQA 127
gi 332375981  54 INVAMFLPVCILGLAGNFWVIYVLKSNKHirtpTNLIVGNMAIADMLSTIVYPCFIFVYDyfqnYQLGAVGCKGEGPLEC 133
gi 45551047   33 WKICTFLPLIAFGLYGNFSMVYVIATNRSlrspTNLIIANMAVADLLTLAICPAMFMVNDfyqnYQLGCVGCKLEGFLVV 112
gi 312380390  23 LKTITFLPVIMFGLLGNAILCYIIAQMRAlrtpTNLLIANLAVTDLATVLVCPLMFMFHDfyqnYVLGAIGCKLEGFLEG 102
gi 167878211  52 IKLTILIPIVLFGILGNVVLLEIIFSNRSlrtaTHLLIANLALIDLVTLLLCPPMFLLHDihqsYVLGSVGCKLEGFIEG 131
gi 270004809  23 IESSIFAPIVLFGIFGNFLSIYVLVKNRHictpTNLLIGNMAAADLLSLLIHPWVFLIYDffqnYQFGSFGCKTEAAVEC 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          #                                          # #####                         #  
gi 195947038 128 SLLLASVGAVMLVSYDRLAAAVltaearitkdAAPKVIVITWIVSSALALPWTIKrkyverqwlnyletfcaedvqlLGI 207
gi 332375981 134 TILLASVISMSAVTYDRLTAIVlpsetridkmKSKIVICSTWIIALILSAPLAIFreyrerkwknfderycteqvivTNI 213
gi 45551047  113 VFLITAVLNLSVVSYDRLTAIVlpmetrltirGVQIVVVCTWVSGILLASPLAFYrsyrvrvwknfteryckentsvLPK 192
gi 312380390 103 SLLITSVLCLCAISYDRLTAIVfpkrsrlskrGAWVLIAVSWICGLLLALPLSMYrayrerqwknyletycaenttfLPS 182
gi 167878211 132 GLLITSVLALCVVSYDRLAAIVlpskarlkntSVAVATGLCWLVGFAAALPFAIYrnyrernwsnfhetfcaedrqvMPL 211
gi 270004809 103 SILLASVISVTAISYDRLTAIVlpqeskltkrGAKIVMVATWVTGILLSTPFYIYrsykerqwldflekyctentmiTNI 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ### ### ##                                                       #  ## ##  #    
gi 195947038 208 YWHLLLTMLVWVPLGIMIITYGVIMWRLqwsaralssrgggrsvtRAKGKAMRIAALVLIAAVVCRIPYTALLYWRnnlp 287
gi 332375981 214 YWYVIITALVWLPLTIQIICYTTIFFKLnkyekiiv-ksfnhhhlGYKKSAAKMMFIVIVTFMICRLPFTAFIIYRhqmv 292
gi 45551047  193 YWYVLITILVWLPLGIMLICYIAIFYKLdryekrvl-srenpltvSYKRSVAKTLFIVVVVFAALRLPFTILVVLRekyf 271
gi 312380390 183 YWHVLIGVLVWFPLLVMFCCYSCIFLKLdryerrvl-rkehpisvSYKRKVAKTLFIVLIVFVLLRIPFTTLVFIRyqry 261
gi 167878211 212 YWDLIVVLLVWLPLGVMLVTYSAILCKLdhyersal-nrehpmvvRYKSRVAKTLFVVLMSFVVVRIPFTVMIMVYykdv 290
gi 270004809 183 YWHVIITVLVWLPLTIQLICYITIFIKLnkyekvvr-rnldhrqvDYKKKAVRMMVSVILTFLICRLPFTALIFYRdikq 261
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
Feature 1                         ## ###  #  ##                     
gi 195947038 288 pki--------nsvdgsFSIMWFAANYLMYLNCTINPLIYGFTNlrFRKAM 330
gi 332375981 293 kssstktadvaniinglYHSLWFSSKYLLIVNAAVNPLIYSVTNisFRNAF 343
gi 45551047  272 ged--------vsvssgMQLFWYISQYLMFLNAAVNPLIYGFNNenFRRAY 314
gi 312380390 262 lndn------qnqigsdFLILWYVSHYLMFLNAALNPLIYGLTNenFRKAF 306
gi 167878211 291 nden-----tfevsegfVMVWWFAKVAFIFLYSAVNPVIYGMTNrtFRKAF 336
gi 270004809 262 snlsqn-tqiqnmasgaYHNLWFASKFFIFVNSALNPLIYSVTNdkFRRGF 311

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