Conserved Protein Domain Family
7tmA_GPRnna14-like

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cd15001: 7tmA_GPRnna14-like 
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.
Statistics
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PSSM-Id: 320132
View PSSM: cd15001
Aligned: 16 rows
Threshold Bit Score: 283.398
Threshold Setting Gi: 443687887
Created: 6-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:
  • Comment:based on the structures of some class A family members with bound ligands (peptides or chemicals), agonists, or antagonists
  • Comment:Small-molecule chemical ligands tend to bind deeper within the receptor core, compared to a peptide ligand neurotensin, which binds towards the extracelllular surface of its receptor.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                               #  ##                    
gi 212517517  34 EIIIIHVIIFVFGVFGNVIVIVVMAGDRKfrsaTNFFLVSLAFGDLLMLCVYGPLETYTHfvikwd-------------- 99
gi 229274832   6 PTILTYAVCFLLGTVGNVLVIFSVARFRRlrstTNYLLGNLATADLLIVALCVPVKAAEFflpswq-------------- 71
gi 229288037   7 PTILTYGITFVVGTLGNALVLFCTVRYKRlraaTTYYLASLAAADLIICFACVPIRTAEYflpqwe-------------- 72
gi 229287908   7 PVLTVATLTVLLGTTGNVLVIFSVCRYRRlrssISFYLVSLATADLFLCCVFTPLKTAEYflpewp-------------- 72
gi 25151251   74 LPGFLYLTVFLVGTIGNSMVIFVVNRFKRmrnvTNIFLASLSTADLCLIWFCVPIMFMKYmshtws-------------- 139
gi 443723441 101 IFVITYSLVMVVGLLGNSMVLVTIGKFLGtksvTNTFIASLACADLLVIMICLPFQINYVwrggwa-------------- 166
gi 229272420  37 PTLVVGAVIFIVGVAGNSVVVASVLRFRQr--gIYFYLLSLSLADLLVLLFGLPMKIAEWfflsew-------------- 100
gi 316970255  53 PLGIWYGLVLILGAIGNSLVITVVIRYRKmrsfTNILLSSMSTADLLILLFCLPVQVDLNfsiifkfihfsslplqycky 132
gi 390354623  54 PVFAVYAITFLVGMTGNLLVIFAVVKSRRlhnvTCFFLANLAVADLLTVVFLIPLQIIVHssdhwn-------------- 119
gi 443713662 123 PYISAYLALSVLGMIGNVIILLAVTLCIPrpsvINVMITSLAIADLFVLAFCAPFQTYATgwstwg-------------- 188
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                   ###### ##  #                                            # #####      
gi 212517517 100 ------etgaiCKTAKFAELVSATSSVLNLLAVTLERFIVIVFPMKsqtfctvsNMIKAVLSVWLLSLIFAFPVVLTtst 173
gi 229274832  72 ------lggflCKATALLQFLSVICSVLTLTCISIERYYGILHPMKartmfmygKARRAVVLIWVLSFLLASPSLAVqgl 145
gi 229288037  73 ------lglfmCKAIAYVQMSSVVCSVLTLTAISIERYYAILHPMKaksictlgRTRKIMAGVWIMALILSSPILYGqtv 146
gi 229287908  73 ------fgpvmCKAVAYIQLLSMSSSVLTLTAIAYERNYIIVYPMKaksactmsRTRRVIALIWITSLILSAPVLYGqql 146
gi 25151251  140 ------mgrfaCYSVHYIQQFTCFCSVLTMTMISFERFLAIAYPMRniwfssigRAKKVILLIWMSSAVLAVPTAVRmdy 213
gi 443723441 167 ------agkyaCYVVIYLYYASYIASCLTLTAMSIERWLAICFPMRaqyasssgRARKTALLVWVISFALAVPAIFVvit 240
gi 229272420 101 -----vlgtamCKILAYLQLLSFTASVMTLTATAIERKFVILNPVKartqqvrrRACRALLLVWGISLILSSPILFPvtt 175
gi 316970255 133 lshswimgaflCVAFHYVELMTMICSLMTMTTISIQRYAAVAFPMKsmsfrskkRALKTVLVTWLFSALLAVPILFGqel 212
gi 390354623 120 ------lgdvmCRLVAYVGVISPVCSVFTMMIISLERYYVVLHPLQarsfvtmgRAKRVITALWLASCIFSSPAIFSkkv 193
gi 443713662 189 ------lgaevCKIMWYFYYACFGISVFTMVVMAFERYLVICHPMKaqiwssvgRAKKTAAGIWLLGAITAIPAAFAyvs 262
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                        #  ### ### ##                                   
gi 212517517 174 yqitftnnvt----------sltlnyctnsgdSPDFVVYQFFIIFFIPSITMTVCYSLv--------------------- 222
gi 229274832 146 vkfdwgtgdt---------iyhcqqvwssvvyERLYVLYGLAVLFVLPLAIMVFSYGCvireivqrrrgqm--------- 207
gi 229288037 147 rgypisaevt---------vyhcqpswpsvvyHQVYIVYGALVIFLLPFIVMVRPVVLvtfalfnggrwvqiftsipltk 217
gi 229287908 147 qrydwpvyta----------yhcqkgwpgplySRLYAIYVAIFLFFIPVIVMVAAYGRasfelwasee------------ 204
gi 25151251  214 etnlslsgqrvhwc--rrrfpaqflgyprtslNKAYAMYQLLLLIIFPVLTMSICYARvsaivyksskdrvilsqamvaf 291
gi 443723441 241 erdscl------------------irirqtplLRFFTVYVGAVIFFIPLIVMATAYTHtaitlwksiktnrem------- 295
gi 229272420 176 vpfegedger---------qwhcahawpsplyGRLYAVYNAVVLLMVPLCVMTYTYIRsghevlaarkggyrgnksrrkg 246
gi 316970255 213 evyktpknvt---------vswcwrrfsdhywEKIFVLYQFVILYLGPFATTAISYLLliqrlyfgeansllqenvsars 283
gi 390354623 194 tahyweeelep-------ysytcnnawpseamSIIYSVYLFLLLFFVPLLIVSYAYMRiachlnstrerssgesngspfn 266
gi 443713662 263 vllierratpfliiqghssgestcgilwmgsyVLYLMSYLAIAIFGVPTVVMTAAYIRigatlyksiavrr--------- 333
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 212517517 223 -------------------------------------------------------------------------IRELWVI 229
gi 229274832 208 -------------------------------------------------------------seskheenavpgDNKGWII 226
gi 229288037 218 ksgsesrtltvahrgwga----------------tqviwflrcyscvsptlcpgdflnlmcalitsiestyfgLTWFQLI 281
gi 229287908 205 ----------------------------------------------------------------vqctcgmfnRHKAAVM 220
gi 25151251  292 skaatdavtfsg----------------------------ysaipmittsrnlktanttiksysnhrnnrvaeANKKQIV 343
gi 443723441 296 -----------------------------------------------------------natakqangkgdagSERLKVI 316
gi 229272420 247 wnicw-----------------------------------------vkclrkirnrrdstdpdsdnvlsahgrGNPLKVI 285
gi 316970255 284 agn---------------------------------------------angstaehqqtcqakssqkrfcprrEQSKKVT 318
gi 390354623 267 rpvlsryrvwyrntsgwssgssfvrraeaasqangvtidddtteadalrsepsrvenlndspaprrhrgtsegDKIQRVI 346
gi 443713662 334 ------------------------------------------------------------klkhsegkdsessDDRIQVI 353
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
Feature 1                     #  ## ##  #                ## ###  #  ##                     
gi 212517517 230 KMLILVIILFYLCWGPRVCMDMLQkfnfi------pfnqsVYKMRIIFNVMTFFHGCINPFIYSFMSkNFRGRL 297
gi 229274832 227 KMLLVVMAVFVCCWGPLLIRHTLVtfdlld-----ehtqlMYALRITFHLLSYLNSCANPVCYAFMSrSFRISF 295
gi 229288037 282 KMLIVVIALFAVCWVPILLLNVLKafdvvn-----tytpeVYYMSIAFQLMGYLNSCVNPICYAFMSkNFRQVC 350
gi 229287908 221 KMLLMVVFLYTMCWAPILLLNMLIefsain-----kntqlVWALQATFELLVYINSCVNPICYAFMSrHFRDGF 289
gi 25151251  344 QMLISIVCMYTVCWLPTIVDELLTsfgyicr---tsntqtLKHMRMGFNALTYCQSCINPILYAFISqNFRSTF 414
gi 443723441 317 QMLISVLVIFAFCWTPNLVMDIAEsfgygil--pglsaknQRYIDRAFACLTFANSCLNPLLYAFLSlQFRTGF 388
gi 229272420 286 KLMAGLVLVFTMCWAPLLIYNLLVkfevis-----rytqaAYILKLALHLLAYSNSCVNPVCYAFLSrHFRSRS 354
gi 316970255 319 KMLVIILLLFFVCWTPTLVDEFLVafdylch---tsptttLKYMRMIFAIMKFSNSCINPIVYAFMSnSFRTTF 389
gi 390354623 347 TMLAIVVALFILSWGPLLTYTLIYrfidd------mpyntHAVLSLFLHLLAACNSCVNPIIYAFLSkNFRQSF 414
gi 443713662 354 RLLMSMLVLFVLCWGPNFIATVFWlanedqrlfgalnfeqGKSVVQGLTILSYANSMLNPFLYMLTSkQYRGAV 427

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