Conserved Protein Domain Family
7tmA_GPR176

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cd15006: 7tmA_GPR176 
orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family
GPR176 is a putative G protein-coupled receptor that belongs to the class A GPCR superfamily; no endogenous ligand for GPR176 has yet been identified. The class A rhodopsin-like GPCRs represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.
Statistics
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PSSM-Id: 320135
View PSSM: cd15006
Aligned: 6 rows
Threshold Bit Score: 511.341
Threshold Setting Gi: 190338368
Created: 7-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:
  • Comment:based on the structures of some class A family members with bound ligands (peptides or chemicals), agonists, or antagonists
  • Comment:Small-molecule chemical ligands tend to bind deeper within the receptor core, compared to a peptide ligand neurotensin, which binds towards the extracelllular surface of its receptor.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                               #  ##              ######
gi 74754475   43 FTTTVQVVIFIGSLLGNFMVLWSTCRTTVfksvTNRFIKNLACSGICASLVCVPFDIILSTSPHCCwwiytmlfCKVVKF 122
gi 134026184  53 FTTSAQVLIFVGSLLGNFMVLWSTCKTSVlksvTNRLMKNLACSGICASLVCVPFDIVLSASPHCCwwiytllfCKIIKF 132
gi 190338368  62 FTTTIQVFILIGSLLGNTAVLWCTIYTNVfksvTNLFIKNLACSGICAGLVCVPFDIALSASPLCClwvhtlllCKAIKF 141
gi 449274725  11 FTTTVQIVIFVGSLLGNIMVLWSTCRTSVlksvTNRFIKNLACSGICASLVCVPFDIALSASPHCCwwiytmlfCRIAKF 90
gi 556952938  63 FTTTVQVVIFVGSLLGNLMVLWSTCRTSVfksvTNRFITNLACSGICASLVCVPYDIVLSASPHCCwwvytllfCKVIKF 142
gi 632942167  56 FTTSVQILIFVGSVLGNVMVLWSTCRTSVfksvTNRFIKNLACAGICASVVCVPFDIVLSASPHCCwwiytlvfCKVMKF 135
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         ##  #                                          # #####                        #
gi 74754475  123 LHKVFCSVTILSFPAIALDRYYSVLYPlerkisdaKSRELVMYIWAHAVVASVPVFAVTNVADiyatstctevwsnslGH 202
gi 134026184 133 LHKVFCSVTILSFAAIALDRYYSVLYPlerkisdsKARDLLIYIWAHAVVASVPVFAVTNVTDiyamstcspswghslGH 212
gi 190338368 142 LHRLFCSATVLSFAVIALDRYYSVLYPlerkisdaRSRDLVIYIWVHAVLASVPVFAVSNVTDvyatssc--sdgqslGH 219
gi 449274725  91 LHKVFCSVTILSFPAIALDRYYSVLYPlerkisdaKSRDLVIYIWAHAIVASVPVFAVTNVSDiyamstcsetwsyslGH 170
gi 556952938 143 LHKVFCSVTVLSFTAIALDRYYCVLYPlerkisdaKSRDLVIYIWVHAVVASAPVFAVTNVTDiyamsdctdswgyslGH 222
gi 632942167 136 LHKVFCSVTVLSFTVIALDRYYSVLYPlerkisdtKSRDLVIYIWIHAVIASVPVFAVTNVTDiyamstctgsrsysvGH 215
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          ### ### ##                                                                #  #
gi 74754475  203 LVYVLVYNITTVIVPVVVVFLFLILIRRALsasqkkkviiaalrtpqntisiPYASQREAELHATLLSMVMVFILCSVPY 282
gi 134026184 213 LVYVLVYNVTTVFIPVVVVFLFMLLIRRALsasqkkkviiaalrtpqntisiPYVSQKEAELHAMLLSMVVVFIICSVPY 292
gi 190338368 220 LVYMITYSITTLILPLAVVFLAMVLIRRALstsqkkkviiaalrtpqnsisiPYVSQREAELHATLLSIVLVFTLCSTPY 299
gi 449274725 171 LIYVIIYNITTVIVPVAVVFLFMILIRRALsasqkkkviiaalrtpqntisiPYASQREAELHAMLLSMVMIFIFCSVPY 250
gi 556952938 223 LVYVIIYNITTVILPLTVVFLFMVLIRRALsasqkkkviiaalrtpqntisiPYVSQREAELHAMLLSMVVTFIICSVPY 302
gi 632942167 216 LVYVIIYNITTIILPVAVVFLLMILIRRALsasqkkkviiaalrtpqniisiPYVSQREAELHAMLLSMVLIFIVCSVPY 295
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
Feature 1        # ##  #        ## ###  #  ##                     
gi 74754475  283 ATLVVYQtvlnvpdtSVFLLLTAVWLPKVSLLANPVLFLTVNKsVRKCL 331
gi 134026184 293 VTLVIYRtmlnsshiSDFLLLTAIWLPKVSLVTNPLLFLTVNKsVRKCV 341
gi 190338368 300 AALLIYHailgaakaSSWLRLTAIWLPKVSLLTNPLFLLTVNRsVRRCL 348
gi 449274725 251 VTLVIYRtilnisdiSVFLLLTAIWLPKVSLLANPLLFLTVNKsVRKCL 299
gi 556952938 303 MTMVVYKtilnisevSIFLLLTAVWLPKISLLANPLLFLTVNKsVRKCL 351
gi 632942167 296 MIYVIYRtilnitdiSASLMLTAIWLPKISLLANPLLYLTINKsVRKCL 344

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