Conserved Protein Domain Family
7tmA_GPR75

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cd15007: 7tmA_GPR75 
G protein-coupled receptor 75, member of the class A family of seven-transmembrane G protein-coupled receptors
G-protein coupled receptor 75 (GPR75) is an atypical chemokine receptor that is expressed by mouse and human islets. Although GPR75 shows low sequence homology to C-C chemokine receptors, chemokine (C-C motif) ligand 5 (CCL5) has been shown to act as an endogenous ligand for GPR75. CCL5 plays a key role in recruiting lymphocytes to sites of inflammatory and infection through promiscuous binding to the C-C chemokine G-protein-coupled receptors. Although categorized as a member of the rhodopsin-like class A GPCRs, GPR75 contains HRL-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. GPR75 is coupled to the G-protein G(q), which elevates intracellular calcium.
Statistics
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PSSM-Id: 320136
View PSSM: cd15007
Aligned: 4 rows
Threshold Bit Score: 416.601
Threshold Setting Gi: 410901523
Created: 7-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:
  • Comment:based on the structures of some class A family members with bound ligands (peptides or chemicals), agonists, or antagonists
  • Comment:Small-molecule chemical ligands tend to bind deeper within the receptor core, compared to a peptide ligand neurotensin, which binds towards the extracelllular surface of its receptor.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                 #  ##              ####
gi 67460986   44 TCTFLLAVIFCLGSYGNFIVFLSFFDPAFrkfrtnFDFMILNLSFCDLFICGVTAPMFTFVLffssas--sipdaFCFTF 121
gi 148234720  40 TCTFLLVIIFCLGSYGNLVVFLSFFDPAFrkfrtnFDFMILNLSFCDLFICCISAPMFAFVLfldsgk--nvpdaFCFTF 117
gi 465950598  53 TCTFLLALIFCLGSYGNLIVFLSFFDPAFrkfrtnFDFMILNLSFCDLFICGVTAPMFAFVLffnsvn--gvpdaFCFTF 130
gi 410901523  38 FCSLLLIFIFCLGSYGNLVVFLSFFDPVFrkfrtnFDFMILNLSFCDLFICCVTAPMFALVLfldagggggvsksFCFAF 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ## ##  #                                           # #####                     #
gi 67460986  122 HLTSSGFIIMSLKTVAVIALHRLRMVLGKQpnrtasFPCTVLLTLLLWATSFTLATLATLkts--kshLCLPMssliagK 199
gi 148234720 118 HLTSSGFIIMSLKTVAVIALHRLRMVLGQQpnrtasFPCTLMLTVLLWTTSFTLATLATLrtr--ksrICLPMyslingE 195
gi 465950598 131 HLTSSGFIIMSLKTVAVIALHRLRMVLGKQpnrtasFPCTLLLTLLLWATSFTLATLATLrtr--ksrLCLPMsslisgE 208
gi 410901523 118 HLTSSGFIIMSLETVAVIALHRLRMVLGQQpnrtasFPCTLTLTALLWTSSFTMAALLTMrayphrdgPCLPHfglrgdQ 197
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          ### ### ##                                                                    
gi 67460986  200 GKAILSLYVVDFTFCVAVVSVSYIMIAQTLRknaqvrkcppvitvdasrpqpfmgvpvqgggdpiqcampaly-rnqnyn 278
gi 148234720 196 GKIILYLYVIDFTFCVAIVSVSYIMIAQTLRknaqvrkcpvitvdtsrpqpfigpavdgvhcavpalyrn-------qny 268
gi 465950598 209 GKIILYLYVSDFICCVAVVSVSYIMIAQTLRrnaqvrkcppiitvdasrpqpfigprasggvdgvqcampaly-rnqnyn 287
gi 410901523 198 ARVVLYVYLADFAFCVAVVSVSYLMIAHTLRknvqvrkcpiiavdaacpqppppliaagfenmqcavqgqplyrnqaynk 277
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                               #  ## ##  #         ## ##
gi 67460986  279 klqhvqtrgytkspnqlvtpaasrlqlvsainlstAKDSKAVVTCVIIVLSVLVCCLPLGISLVQVvlssngsFILYQFE 358
gi 148234720 269 nklqhvqthaytkklsqvpvpasrlqlvsavnlstAKDSKAVVTCVVIVLSVLICCLPLGISLVQDvltsnssFILYQFE 348
gi 465950598 288 klqhvqthgysknlsqlpapastrlqlvstvnlstAKDSKAVVTCVVIVLSVLVCCLPLGIFLVQDvlssnggFILYQFE 367
gi 410901523 278 lqnaqapscasqpvapgaaqgatccqlvstvnlatAKDSKAVFTCVVIVFSVLLCCLPMGVSLAQDvlspessFAHYQFE 357
                        330       340
                 ....*....|....*....|....*....
Feature 1        #  #  ##                     
gi 67460986  359 LFGFTLIFFKSGLNPFIYSRNSaGLRRKV 387
gi 148234720 349 LCGFTLIFLKSGLNPFIYSRNSaGLRRRV 377
gi 465950598 368 LCGFTLIFFKSGLNPFIYSRNSaGLRRRV 396
gi 410901523 358 LCGFVLIFVKSGVNPFVYSRNSaGLRRRV 386

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