Conserved Protein Domain Family
7tm_TAS2R40

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cd15014: 7tm_TAS2R40 
mammalian taste receptor 2, subtype 40, member of the seven-transmembraneG-protein coupled receptor superfamily
This group includes the mammalian taste receptor 2 (T2R) subtype 40, which functions as a bitter taste receptor. The human TAS2R family contains about 25 functional members, which are glycoproteins and have the ability to form both homomeric and heteromeric receptor complexes. Five basic tastes are perceived by animals: bitter, sweet, sour, salty, and umami (taste of glutamate MSG). Among these, sour and salty are mediated by ion channels, while the perception of umami and sweet tastes is mediated by the TAS1R taste receptors, which belong to the class C GPCR family. The TAS2Rs in humans have a short extracellular N-terminus and the ligand binds within the transmembrane domain, whereas the TAS1Rs have a large N-terminal extracellular domain composed of the Venus flytrap module that forms the orthosteric (primary) ligand binding site. Signal transduction of bitter taste involves binding of bitter compounds to TAS2Rs linked to the alpha-subunit of gustaducin, a heterotrimeric G protein expressed in taste receptor cells. This G-alpha subunit stimulates phosphodiesterase and decreases cAMP and cGMP levels. Further steps in the signaling cascade is still unknown. The beta-gamma-subunit of gustducin also mediates bitter taste transduction by activating phospholipase C, which leads to an increased formation of IP3 (inositol triphosphate) and DAG (diacylglycerol), thereby causing release of Ca2+ from intracellular stores and enhanced neurotransmitter release.
Statistics
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PSSM-Id: 320142
View PSSM: cd15014
Aligned: 3 rows
Threshold Bit Score: 463.255
Threshold Setting Gi: 29839473
Created: 21-Jan-2014
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:TM helix 1 [structural motif]
Evidence:
  • Comment:All members of this receptor family contain a seven-transmembrane helix domain.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ##########################                                                     
gi 29839473  19 TFTLVVSGIECITGILGSGFITAIYGAEWARgktLPTGDRIMLMLSFSRLLLQIWMMLENIFSllfrivynqnsvYILFK 98
gi 81872210  18 IIPFVVSTIDCIVGIIGNGFITVIYGTELVRskrLPTGEHLMLMLSFSRLLLQIWIMVEITYQlffpmiynhnamYKLFK 97
gi 41018284  18 IIPFVVSTICSIVGIIGNGFITVIYGTEWVRskrLPTGENLMLMLSFSRLLLQIWMMVEITYSllfpiiynhnamYKLFK 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
gi 29839473  99 VITVFLNHSNLWFAAWLKVFYCLRIANFnhPLFFLMKRKIIVlMPWLLRLSVLVSLSFSFPLsrdvfnvyvnssipipss 178
gi 81872210  98 TISVFLNYCNLWFAAWLNVFYCLKIVNFahPLFLMMKQKIVVlMPRLMSLSVLVSISLSSFFskdifnvymntsvpipfs 177
gi 41018284  98 AISVFLNYCNLWFAAWLNVFYCLKIVNLahPLFLLMKQKIIGlMPRLLSLSVLVSFSLSSFFskdilnvyvntsvpipss 177
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
gi 29839473 179 nstekkyfsetNMVNLVFFYNMGIFVPLIMFILAATLLILSLKRHtlhmgsnatgsrDPSMKAHIGAIKATSYFLILYIF 258
gi 81872210 178 nstkmkyffktNVLNLAFLYYMGIFIPLFMFIMAAILLITSLKRHtlnmessttgsrDSSMEAHLGAIKSTSYSLILYII 257
gi 41018284 178 nstkmkyifmiNVLSLAFLYYMGIFLPLFMFIMAATLLITSLKRHtlhmensttgsrDSSMEAHVGAIKSTSHSLILYII 257
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
Feature 1                                                         
gi 29839473 259 NAIALFLStsnifDTYSSWNILCKIIMAAYPAGHSVQLILGNpGLRRAWK 308
gi 81872210 258 NALALFISmsnifGAYSTWNSVCSFILTAYPAGQSVHLILRNpGLRRAWR 307
gi 41018284 258 NALALFISmsnilGAYSVWNSLCNIIMTAYPAGQSVHLILRNpGLRRAWR 307

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