Conserved Protein Domain Family
7tm_TAS2R1

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cd15016: 7tm_TAS2R1 
mammalian taste receptor 2, subtype 1, member of the seven-transmembrane G protein-coupled receptor superfamily
This group includes the mammalian taste receptor 2 (TAS2R) subtype 1, which functions as a bitter taste receptor. The human TAS2R family contains about 25 functional members, which are glycoproteins and have the ability to form both homomeric and heteromeric receptor complexes. Five basic tastes are perceived by animals: bitter, sweet, sour, salty, and umami (the taste of glutamate, MSG). Among these, sour and salty are mediated by ion channels, while the perception of umami and sweet tastes is mediated by the TAS1R taste receptors, which belong to the class C GPCR family. The TAS2Rs in humans have a short extracellular N-terminus and the ligand binds within the transmembrane domain, whereas the TAS1Rs have a large N-terminal extracellular domain composed of the Venus flytrap module that forms the orthosteric (primary) ligand binding site. Signal transduction of bitter taste involves binding of bitter compounds to TAS2Rs linked to the alpha-subunit of gustaducin, a heterotrimeric G protein expressed in taste receptor cells. This G-alpha subunit stimulates phosphodiesterase and decreases cAMP and cGMP levels. Further steps in the signaling cascade is still unknown. The beta-gamma-subunit of gustducin also mediates bitter taste transduction by activating phospholipase C, which leads to an increased formation of IP3 (inositol triphosphate) and DAG (diacylglycerol), thereby causing release of Ca2+ from intracellular stores and enhanced neurotransmitter release.
Statistics
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PSSM-Id: 320144
View PSSM: cd15016
Aligned: 30 rows
Threshold Bit Score: 318.775
Threshold Setting Gi: 89111386
Created: 13-Nov-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:TM helix 1 [structural motif]
Evidence:
  • Comment:All members of this receptor family contain a seven-transmembrane helix domain.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         ##########################                                                     
gi 29839667    7 IIYFLLAVIQFLLGIFTNGIIVVVNGIDLIKhrKMAPLDLLLSCLAVSRIFLQLFIFYVNVIViFFIEfi----mCSANC 82
gi 89111384    7 IIQLILGVVQFLTGIVANGIIVIVSGIECIKrkKVTAYDLLLISLGIFRIFLQALILTCHMIFvFTLNiy----vEKEAF 82
gi 89111386   14 VCYTSVLIALFIMGTIGNGFLVVVNGSKLMGdqRLIGIELLLLCLGMSRLGLQILLTFQGLISvFFAKfylhnvyGSLFL 93
gi 674058585   7 VFHLLAAVLQVFTGLLANGLILVVNGIDFIRqrKIAPFDLLLSCLVTSRIILQLCVFSGLLVAlFLVNss----vFTDNA 82
gi 533188406   7 IIYFLVAVTQVLTGVFANGFIMVVNMVDFIKqrKMAPLDLLISCLVTSRICLHFLILFEHIAVlSFMKqs----vFAELN 82
gi 507574223   7 IIYFLLVLLQVFSGILANGLIVRVNGAEWIMqrKIASLDLLLFCLAISRILLQLHIFGCQLSFhLLVTpf----lSAETM 82
gi 507621165   7 ILHLLIVVAQFLTGVFINGFIVVDHAVDFIRqrSMRPLDLLIFCLATSRVCLQICSFILPLAVfSFIKql----aLQKLT 82
gi 507621155   7 IIHFFIVAAQSLIGVFINGFIVVVNAVGFFRqrEMDPLDLIIWCLAFSRICLQISFFLLPLSLfFFIKqs----vLQEVN 82
gi 507621151  15 IIHFIMLVAQFLTGIFINGFIIVVNAVGFIRhrQMSPLDLLISCLVTSRICLQLFVFLLSLAVlSFINqs----vLQELN 90
gi 507621143   7 IIYSLIAVTQLLAGVFTNGFIMVVNVVDFIRqrHMAPLDLLISCMVTSRISFQLFNFLVQLVLlSFVKqs----iFQELN 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 29839667   83 AILLFINELELWLATWLGVFYCAKVASVrhpLFIWLKMRISKlVPWMILGSLLYVSMICVFHskyagfmvpyflr-kffs 161
gi 89111384   83 LFFIFVNEVNLWLATYLCLFYCVKIANIfhpFFLWLKMRISRlVPWLILGSLLFSLALSVCYlllywpeakeeir-ryfs 161
gi 89111386   94 FIWMFLNSCSLWFATCLGIFYCLKISDFthpCFLWLKFRVFKlMPWMLLGSLLASVVIAGLCacmldysiasntdwaknv 173
gi 674058585  83 IFIMFINELNLWFATWLGVFYCTKIATIphpLFLWLKMKIFRlVPWLILGSVLYATVTASIYsknvssayiqpfi--nif 160
gi 533188406  83 IIFMFVTIWGLWLATWLGVFYCAKIATIphpLFFWLKMRISNlVPWLILGSTLYASLSTGIYakhawtitqnflv--nff 160
gi 507574223  83 VTLSFTNELSLWFATWLGVFYCAKIATVrhpLFLWLKTRISRlVPWLILGSLLYTVAMCSIYskpmmetyqslfm--nli 160
gi 507621165  83 MILTFINIWALWLATWLSVFYCAKIATIphpLFSWLKMKISKlVPWLILGSSVYTAISTGIHrnyiwtvtqkilg--dff 160
gi 507621155  83 TLFSFTNIWGLWMATWLNVFYCAKIANIqhpLLFWLKRNISKlVPWLILGSVLYAAIGTSMHrnylwtvtqkflg-nfls 161
gi 507621151  91 AIITFTNIWGLWLATWLSVFYCAKISTIphpLFSWLKMKISKlVPWMILGSALFAAIGTGFH------------------ 152
gi 507621143  83 IIIIFINNWGLWLATWLSVFYCAKITAIthpLFSWLKKVPKL-VPWLILGSTLYAATITGIQrthihaiskellv--kfl 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 29839667  162 qnatiqkedTLAIQIFSFVAEFSVPLLIFLFAVLLLIFSLGRHtrqmrntvagsrVPGRGAPISALLSILSFLILYFSHC 241
gi 89111384  162 gnltasnflSSLFPVPILVVGLIVPLVIFDASLFLMIYSLCRHtrkmks-matgrDLSTEAHIRAVKSVFSFFILYTSYY 240
gi 89111386  174 sqagadsvsVIINDVLLVNFALICPLCLFVMCTVMLFVSLYNHthrmqtqsldlgNPNTEAHINALRTVITFFCFFVSYF 253
gi 674058585 161 sqnvthlkeMYALPSSFSAFGLMLPFLIFLVAVLLLIFSLWKHsrkmrtistgsrKPGRHAHISAMLSILSFLTLYFSHC 240
gi 533188406 161 sknvtqikgIDFVLLSTLIFHISVPLIIFLIAVLLLVFSLGRHaqqmrstamgtqDPHRGAPIRAVLSILSFLILYSSHY 240
gi 507574223 161 tknsthipeIDRELLSYFIFGFTVPLSIFLVAGLLLTVSLVRHahrmrtvkmgtrGPSRHAHLSAVFSILSFVILYFSHY 240
gi 507621165 161 lsnethtrrIDIAPLSIYIFHLTVPSVIFLIAVLLLIISLGRHalkmrktamgtqEPCCSAPLKAMLTILSFLFLYFSYY 240
gi 507621155 162 ssnethtkrIDIVPLSILLFHLIIPLSIFLIAALLLVSSLGRHvwkmrtvatetrDQCFSAPLRAIVTILSFFILYLCYY 241
gi 507621151 153 ---------RNYIHTLTEKFLGDVPLIIFLCTTLLLIFSLGRHtwkmrtiakvtwNPSCGVPLRAMLSILSFLILYLFYY 223
gi 507621143 160 ssngtqtkrVGVMSLPMFTFHLLVPLIIFLIATLFLILSLGRHayqmrtitmvtrDLCSSASIKALLSVLSFLIIYLSYY 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
Feature 1                                                        
gi 29839667  242 MIKVFLsslkfHIRRFIFLFFILVIGIYPSGHSLILILGNpKLKQNAK 289
gi 89111384  241 MGIIISlsrtsSQNEFFMFICFFVAAEYPSGHSIILILGNpKLKHYAR 288
gi 89111386  254 AALMVNltfivPFKSHWFFFLKSVMAAYPSGHSVIIILGNsQYWQLFK 301
gi 674058585 241 MVGILLstqviQFGSTNFLLCILMMGVYPSIHSIILILGNpKLRQSAW 288
gi 533188406 241 MMVLLFffqilQFGSSLYEFCTLVSGTYPSIHSVVLILGNsKLKQKAK 288
gi 507574223 241 LLIMLLswqvlPFDSIAFLFCTLMVGAYPSVHSTILILGNpKLKQRAK 288
gi 507621165 241 GTAIVLstqdlKNGRIYILLWNLIGGSYPSTHSVILMLGNpKLKENAK 288
gi 507621155 242 TSAIVFctqdsQYGRLFVLSWSLIGGCYPAIHSVILVLSNdKLKQNAK 289
gi 507621151 224 TRAIVFnsqdlQYEKSFILLWNLIGGSYPSIHTVILISGNsKLKKNAK 271
gi 507621143 240 VMTLVFsfqswRHDKFFILLFNLLFGAYPSIHSFILILGNpKLKQIAR 287

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