Conserved Protein Domain Family
7tm_TAS2R16

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cd15017: 7tm_TAS2R16 
mammalian taste receptor 2, subtype 16, member of the seven-transmembrane G protein-coupled receptor superfamily
This group includes the mammalian taste receptor 2 (TAS2R) subtype 16, which functions as a bitter taste receptor. The human TAS2R family contains about 25 functional members, which are glycoproteins and have the ability to form both homomeric and heteromeric receptor complexes. Five basic tastes are perceived by animals: bitter, sweet, sour, salty, and umami (the taste of glutamate, MSG). Among these, sour and salty are mediated by ion channels, while the perception of umami and sweet tastes is mediated by the TAS1R taste receptors, which belong to the class C GPCR family. The TAS2Rs in humans have a short extracellular N-terminus and the ligand binds within the transmembrane domain, whereas the TAS1Rs have a large N-terminal extracellular domain composed of the Venus flytrap module that forms the orthosteric (primary) ligand binding site. Signal transduction of bitter taste involves binding of bitter compounds to TAS2Rs linked to the alpha-subunit of gustaducin, a heterotrimeric G protein expressed in taste receptor cells. This G-alpha subunit stimulates phosphodiesterase and decreases cAMP and cGMP levels. Further steps in the signaling cascade is still unknown. The beta-gamma-subunit of gustducin also mediates bitter taste transduction by activating phospholipase C, which leads to an increased formation of IP3 (inositol triphosphate) and DAG (diacylglycerol), thereby causing release of Ca2+ from intracellular stores and enhanced neurotransmitter release.
Statistics
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PSSM-Id: 320145
View PSSM: cd15017
Aligned: 17 rows
Threshold Bit Score: 360.069
Threshold Setting Gi: 507667729
Created: 13-Nov-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:TM helix 1 [structural motif]
Evidence:
  • Comment:All members of this receptor family contain a seven-transmembrane helix domain.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         ##########################                                                     
gi 29839657    8 VFFMIIYVLESLTIIVQSSLIVAVLGREWLQvrrLMPVDMILISLGISRFCLQWASMLNNFCSYfnl--nyVLCNLTITW 85
gi 62287851    7 LIFIAIFCLESLAAMLQNGFLVTMLGREWVRcrmLSTSDMIVACLAASRFCLHGVAMANNLLASldf--srAVPYMNIFW 84
gi 29839467    8 IFSIIMYVLESLVIIVQSCTTVAVLFREWMHfqrLSPVETILISLGISHFCLQWTSMLYNFGTYsrp--vlLFWKVSVVW 85
gi 89111442    7 LFFMIFFLLESVIAIVENSFIFMILGREWMRcrtLPPGDIILASLGISRFFLQWMSIFSNFFTYffp--lkLSVYFGTFW 84
gi 640789507   7 LVCVVIFCLESLATMLQNVFMVTVLCREWVQgqaLPTGDMIVACLATSRFCLHVVTMLSNFLTSfdl--cfHLDCSFMIW 84
gi 395833717   7 LIFMIIYGLESWIIIVQSSLVVAVLGREWLQarkLSPVDMILISLGVCRFCVQWTSIVFNFCSYfnp--dhVCWYFPIIW 84
gi 562840295   8 IFFMTIYMLESLIIIVQSSLIIVVLGREWVQfkrLSPVDIIIISLGICHFCLQWASILFDFCSFfdl--nyILWCFSVTW 85
gi 395539576   6 IVFFMIFLLESVVEIIGNGFIIVVLGREWMRcwtLTPGDMILANLDISRFFLQWTAIISDFCSYffs--psKGVLLGMMW 83
gi 395847481   7 SIFLVIFCLESLAAMLQNGFIVTVLGREWLRgrvLPAGDTIVACIATSRLGLHGVAMLNGLLGSfdfcgnrHLFFVNIIW 86
gi 585717799   8 VFFMLLYVLLSLTIVVQSTFIVAVLGREWVKvkrLSPLDMILISLGVSKLCLQCISIFYNFYSYfdy--nyICLRVGTTW 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 29839657   86 EFFNILTFWLNSLLTVFYCIKVSSFthHIFLWLRWRILRLFPWILLGSLMITCVTIIPSAIGNyiqiqlltmehl-prns 164
gi 62287851   85 DLFNALTLWFTALLAAFYCVKISSFshPTFAWLKWRISRLVPKLIKGSLIICGLEVISSATGNilfgqrkvslssyrnet 164
gi 29839467   86 EFMNILTFWLTSWLAVLYCVKVSSFthPIFLWLRMKILKLVLWLILGALIASCLSIIPSVVKYhiqmelvtldnlpknns 165
gi 89111442   85 TFSNMTTFWFTTCLGVFYCVKISAFthPVFLWLKWRIPQMIHLFLFCSLLTSILLTTPQILTTfltfqvkvpgnssekti 164
gi 640789507  85 NFFNILNFGFTAWLAAFYSVKISSFshPTLVWPKGRISRSLHRLMLGSMVFCVLSLISSFIGKtilaqrtdslsaygnst 164
gi 395833717  85 EYSNILIFWLTGLLSVVYCVKVFSLthSTFLWLRWRIVRLVPWLLLGCLMISCLAIIPSIINNliqhqvittghlpknst 164
gi 562840295  86 EFTNTLIFWLTSLLAVFYCAKVSSFthPKFLWLKWRILRLIPQLVLGSLMICCVSMIPSIFKNyfrvllitmdyaptndt 165
gi 395539576  84 NLPNVTTFWFTTLLAVFYCVKLSSFnhSIFFWLKWRISRFVPWLLLWSLVLSILISILSFVKGyhvlqfpvignysekti 163
gi 395847481  87 DFFNILSFWLTAWLAAFYCVKISSFshSTFFWLKWRVSRSVPRLLLGSLVICVLSIISSIVGNlmlaqrtaslnscgnst 166
gi 585717799  86 HVVNTAIFWFNSLLAVFYCVKVSSFthPIFLWLKWRISRLVPWMLLGTLLISCMVCIPSTIQDhlwfqlnvksft-anst 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 29839657  165 tvtdklenFHQYQFQAHTVALVIPFILFLASTIFLMASLtkqiqh---hstghcNPSMKARFTALRSLAVLFIVFTSYFL 241
gi 62287851  165 lvyrvqasFQLYFFLYDGFVWSIPFLLFLVSTVLLIVSLcwqlgqmrdlrpgpcDPSTQAYTMALKSLTFSLIFCTLYFL 244
gi 29839467  166 lilrlqqfEWYFSNPLKMIGFGIPFFVFLASIILLTVSLvqhwvqm--khysssNSSLKAQFTVLKSLATFFTFFTSYFL 243
gi 89111442  165 ledkmcayRIHYFMPMQLFILLLPFLFFLVSIIFLISTLcrhlgkmqhhssslqDPSMQVHITALKSLFFFLILYTSYFL 244
gi 640789507 165 lfyrnqtfQQYYFLFHEGISLSIPFLLFLVSIILLIFSLfqhlgqmtghrpgprDPSTQAHVTALKSLAFFLIFSSLYFL 244
gi 395833717 165 vivrlemiRHHLICAHKVLALGVPFLLFLTSIIALIAALtqhvqrmqhcttghgSTSRKAHAAALKSLATLFIFFTSYFL 244
gi 562840295 166 mierlkvfPWNFFKFHQLVVLFIPFILFLASIVSLMTSLkqhseqmrhynaghcNSNMRAHSTALKSLIIFVIFFTSYFL 245
gi 395539576 164 lnanirafQIHFFLPLQLFILLIPFFVFLVSIILLTSSLcqhlgnmehhsadpqDPRMQVHIITLKSLFFFLILFTSYLL 243
gi 395847481 167 liykiemiQKSYFILQEKILLCVPFLLFLTSTVLLLSSLrlhlgr---mrarrrDASTQAHTAALKSLAFFLVFYVMYFL 243
gi 585717799 165 mlerlsvfQQYAGIPHQIVMLMIPFLLFLASIIMLIASLlqhwrqm--khhspgHSSKDVHFAALKSLAIFLIFFSSYFL 242
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
Feature 1                                                       
gi 29839657  242 TILITiigtlFDKRCWLWVWEAFVYAFILMHSTSLMLSSpTLKRILK 288
gi 62287851  245 SLFASalkiiNFQNHWHWAWEVLIYANICLHSTVLVLRSpKLKKGLK 291
gi 29839467  244 TIVISfigtvFDKKSWFWVCEAVIYGLVCIHFTSLMMSNpALKKALK 290
gi 89111442  245 PLIIStiipiSVSSSWFWVREVVTYAGISIHPAFLILNSpKLRGALK 291
gi 640789507 245 SLIISamkiiDFQNHWRCFWEVISYSNICLHSTILVLSSpKLRKALK 291
gi 395833717 245 TILFSlihnqSVNGFWYWVREAVIYAVVSINSTSLMASSpTLKKALK 291
gi 562840295 246 SVVIAlsfslFDKRPWFWIWEDVIYALVSIRSTLLMLSSpTVRKNLK 292
gi 395539576 244 PLIITttapiSVCSSWFWIREVVTYAGISIHPAFLILNTsKLRRALK 290
gi 395847481 244 SLNISwgkieTFTNYWHWGWEVAIYAGISLHSTFLVLNSpKLRKALQ 290
gi 585717799 243 TVFISiigylFEKQSWFWIWEAVIYAGSCVHSTSLTLSSpTLRKYLK 289

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