Conserved Protein Domain Family
7tm_TAS2R41-like

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cd15018: 7tm_TAS2R41-like 
mammalian taste receptor 2, subtype 41, member of the seven-transmembrane G protein-coupled receptor superfamily
This group includes the mammalian taste receptor 2 (TAS2R) subtype 41, which functions as a bitter taste receptor. Also included is the closely related TAS2R60. The human TAS2R family contains about 25 functional members, which are glycoproteins and have the ability to form both homomeric and heteromeric receptor complexes. Five basic tastes are perceived by animals: bitter, sweet, sour, salty, and umami (the taste of glutamate, MSG). Among these, sour and salty are mediated by ion channels, while the perception of umami and sweet tastes is mediated by the TAS1R taste receptors, which belong to the class C GPCR family. The TAS2Rs in humans have a short extracellular N-terminus and the ligand binds within the transmembrane domain, whereas the TAS1Rs have a large N-terminal extracellular domain composed of the Venus flytrap module that forms the orthosteric (primary) ligand binding site. Signal transduction of bitter taste involves binding of bitter compounds to TAS2Rs linked to the alpha-subunit of gustaducin, a heterotrimeric G protein expressed in taste receptor cells. This G-alpha subunit stimulates phosphodiesterase and decreases cAMP and cGMP levels. Further steps in the signaling cascade is still unknown. The beta-gamma-subunit of gustducin also mediates bitter taste transduction by activating phospholipase C, which leads to an increased formation of IP3 (inositol triphosphate) and DAG (diacylglycerol), thereby causing release of Ca2+ from intracellular stores and enhanced neurotransmitter release.
Statistics
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PSSM-Id: 320146
View PSSM: cd15018
Aligned: 8 rows
Threshold Bit Score: 384.458
Threshold Setting Gi: 671009540
Created: 13-Nov-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:TM helix 1 [structural motif]
Evidence:
  • Comment:All members of this receptor family contain a seven-transmembrane helix domain.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         ##########################                                                     
gi 261260079   7 AFFVLLFSLLSLLGIAANGFIVLVLGREWLRygrLLPLDMILISLGASRFCLQLVGTVHNFYYsaqkvEYSGGlgRQFFH 86
gi 29839425    7 VFFMSIFVLLCFLGILANGFIVLMLSREWLWrgrLLPSDMILLSLGTSRFCQQCVGLVNSFYYslhlvEYSRSlaRQLIS 86
gi 29839489   18 IILVTILLLLRLVAIAGNGFITAALGVEWVLrrmLLPCDKLLVSLGASRFCLQSVVMGKTIYVflhpmAFPYNpvLQFLA 97
gi 89111440   13 ITLIAFFFFLCLILIVENGYILVVLGREWAQcgtLTPVNKILTCLSASRFLLQWGVCGKNLYVllypmVFPYNpvHQYLS 92
gi 55976698    7 AFFMLLFSLLSLLGIAANGFIVLVLGREWLRygrLLPLDMILLSLGAFRFYLQLVGMGHNFYHsahvvERSGVltQQFFH 86
gi 351712867  27 LILIIILFLLCLVAVMGNGFVVVALGMKWFLrrtLSSYNKLLVSLGAYRFCLQWAVIGKSIYNvlhptALPYDptMQFLN 106
gi 81872202   27 ITLFVILVFSCLVAVVGNGFIIIALGMKWLLrrtLSAHNKLLISLAASRFCLQCVVIGKNIYVflnpsSFPYNpvIQLLN 106
gi 671009540 109 SRSVPRLLLGSLVLAVSNGFINVALSMERLLqrtLLPCDKLLVSQGXSCLHLQWVVMRKSIYIflypvAFPYNsvLQFLA 188
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 261260079  87 LHWHFLNSATFWFCSWLSVLFCVKIANIthsTFLWLKWRFPGWVPWLLLGSVLISFIITLLFfwvnypvyqeflir--kf 164
gi 29839425   87 LHMDFLNSATFWFGTWLSVLFCIKIANFshpAFLWLKWRFPALVPWLLLGSILVSFIVTLMFfwgnhtvyqaflrrk-fs 165
gi 29839489   98 FQWDFLNAATLWSSTWLSVFYCVKIATFthpVFFWLKHKLSGWLPWMLFSSVGLSSFTTILFfignhrmyqnylrnhlqp 177
gi 89111440   93 FHWDFLNSVSLWSSALLGVFYCVKITTFtdpVVLWLKWRISRFVTWLLFGSFGISLFTAFLFfignyyiyyiysvrslls 172
gi 55976698   87 LHWHFLNSVTFWFCSWLSVLFCVKIANIthpTFLWLKWRFPGWVPWLLLGSVLISFIIALLLfwvnysayqqflir--tf 164
gi 351712867 107 FLWDFLNSATLWSCTWLGFFYCIKIANFthpAFLWLKCKVSGWVPWLLLSCVGFSGLNSILFftgnqilyrsylrdn-cq 185
gi 81872202  107 LMWDFLTAATIWFCSLLGFFYCVKIATLthpVFVWLKYRLPGWVPWMLLSAVGMSSLTSILCfignhmiyqnyarrghqp 186
gi 671009540 189 FQWNLPNTATLWFFTXLSALCCVKTATLtlpIFLGLKQKMSGLVPWMLLGSVGLSSLSTILXfignqslylyflrrg-lq 267
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 261260079 165 sgnmtykwntriETYYFPSLKLVIWSIPFSVFLVSIMLLINSLRRHtqrmqhnghslqDPSTQAHTRALKSLISFLILYA 244
gi 29839425  166 gnttfkewnrrlEIDYFMPLKLVTTSIPCSLFLVSILLLINSLRRHsqrmqhnahslqDPNTQAHSRALKSLISFLVLYA 245
gi 29839489  178 wnvtgdsirsycEKFYLFPLKMITWTMPTAVFFICMILLITSLGRHrkkallttsgfrEPSVQAHIKALLALLSFAMLFI 257
gi 89111440  173 enstmenlrrqlETYYFFPLKVISSSIPAAIFFISMVFLITSLERHkkkmlhsdsglwDFRFQAHTKALKTLISFFILFA 252
gi 55976698  165 sgnmtyewnamtEIYYFPFAQLVIWSIPCSVFLVSIXLLINSLRRHtwrmqhnshslqDPSTQAHTRALKFLISFLILYV 244
gi 351712867 186 ywnvtgnsirsfEKFYFFSLKLITFSIPVGLFLIFMALLLISLGRHtkktllslsgfqDPPLQAHIRALVAIISFVTLLT 265
gi 81872202  187 wnatgnslrhslEKFYFISIKIIMWTVPTVIFSIFMSLLLVSLVRHmkktllalselrDVWAQAHFKALLPLLSFIILFI 266
gi 671009540 268 swnairntirshEKSYFFSLKLVTCTVFTVVFLVGMVLLMSLERHXegpav--hrsfrDSSVQAHIKILLALISFAIVFT 345
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
Feature 1                                                           
gi 261260079 245 LSFLSLIIDaakfiSMQNDFYWPWQIAVYLCISVHPFILIFSNlKLRSVFS 295
gi 29839425  246 LSYVSMVIDatvviSSDNVWYWPWQIILYLCMSVHPFILITNNlKFRGTFR 296
gi 29839489  258 SYFLSLVFSaagifPPLDFKFWVWESVIYLCAAVHPIILLFSNcRLRAVLK 308
gi 89111440  253 SYFFAIMVNasnilPSLKSWYWGWQALIYLCIAIHSMLLILNNpRLLCWRR 303
gi 55976698  245 LSFLSLIIDgtkfiSMQNDFYWPWQIAVYLSVSVHPFILIFNNlKLQSVFW 295
gi 351712867 266 SGFLALVLSsgtrfPLQEVKQWVWQVVAHLCIAVHSALLLFSNfKLRGMVE 316
gi 81872202  267 SCFLTLVLSsasstPYQEFRYWMWQVVIHLCTVIHPIVILLSNpVLRVVMK 317
gi 671009540 346 SYFLSPVLSaagvfPXLELRRWVWQAVIYLCTATHPVXLLLSNpRLRGVLE 396

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