Conserved Protein Domain Family
7tm_TAS2R14-like

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cd15019: 7tm_TAS2R14-like 
mammalian taste receptor 2, subtype 14, member of the seven-transmembrane G protein-coupled receptor superfamily
This group includes the mammalian taste receptor 2 (TAS2R) subtype 14, which functions as a bitter taste receptor. The human TAS2R family contains about 25 functional members, which are glycoproteins and have the ability to form both homomeric and heteromeric receptor complexes. Five basic tastes are perceived by animals: bitter, sweet, sour, salty, and umami (the taste of glutamate, MSG). Among these, sour and salty are mediated by ion channels, while the perception of umami and sweet tastes is mediated by the TAS1R taste receptors, which belong to the class C GPCR family. The TAS2Rs in humans have a short extracellular N-terminus and the ligand binds within the transmembrane domain, whereas the TAS1Rs have a large N-terminal extracellular domain composed of the Venus flytrap module that forms the orthosteric (primary) ligand binding site. Signal transduction of bitter taste involves binding of bitter compounds to TAS2Rs linked to the alpha-subunit of gustaducin, a heterotrimeric G protein expressed in taste receptor cells. This G-alpha subunit stimulates phosphodiesterase and decreases cAMP and cGMP levels. Further steps in the signaling cascade is still unknown. The beta-gamma-subunit of gustducin also mediates bitter taste transduction by activating phospholipase C, which leads to an increased formation of IP3 (inositol triphosphate) and DAG (diacylglycerol), thereby causing release of Ca2+ from intracellular stores and enhanced neurotransmitter release.
Statistics
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PSSM-Id: 320147
View PSSM: cd15019
Aligned: 62 rows
Threshold Bit Score: 314.848
Threshold Setting Gi: 504182597
Created: 13-Nov-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:TM helix 1 [structural motif]
Evidence:
  • Comment:All members of this receptor family contain a seven-transmembrane helix domain.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ##########################                                                      
gi 29839658    8 IFTFVLIVEFIIGNLGNSFIALVNCIDWVKgrkISSVDRILTALAISRISLVWLIFGSWCVSVFFPalfatekmFRMLTN 87
gi 291411875   7 ITTAIVGMEFIIGILGNGLIALVNIIDWVKrskISAVDQILTALAISRIIHLSSRHLSKLFSMVCPgllwaeqiLKMIHI 86
gi 504182600   8 VLGVILAVEFIIGNISNGFIALVNCLDWIKkrkTKTCDQILTALAISRLGMMWSVFLPKLIFAYHPalemtkkvSKMMHN 87
gi 585668632   8 ILGFIVSTEIVFGNFGNGLIVLVNCAGWVKkrkISSADKILTALAISRIFHLWVMLTYLYISIFDVdlfldktcLIISCN 87
gi 504182603   8 IFLLIAVVEFIMGNLGNKFIAVVNCIAWTRrrkLYLCDHLLTALAISNICLLWFLFISYLVSIFYPtitfkkeiVSIMNN 87
gi 504182588   8 IFTIILSVECVIGNLVNGFIALVNCIDWIRrrkLSFADQILTALAISRIGQLWFVFFIMFVSVLSPasrvtnnmSKIIIG 87
gi 504182611  10 ILTVISGVERIIGIFSNGFIVLVNFIDWVKrrkVSSVDQILTALAVSRTGLLLLETLYQLICVINPnwiathrmLRMITV 89
gi 504182597  19 GYPGVVYNKSLLGILGNGFITVVNCIDWVKrrkIFLIDQLLIGVSVSRIGTIWFVFLINLGFVFDTisvknetvVKMSAI 98
gi 655888608   8 VFAVILSVEFIIGNAGNGFIALVNSLDWVKgrkISAADQLLTALAISRIGLLWYIFFSGLLSVFYPallftenlTRVSYM 87
gi 504182594   8 VLTLILSAEFIIGNAGNGLIVFVNCIDWVKirkIPLIDRITTALAISRIGLVWYMFLTELGSLLLQdlmsnvnmSKLIYI 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 29839658   88 IWTVINHFSVWLATGLGTFYFLKIANFsnsIFLYLKWRVKKVVLVLLLVTSVFLFLNIALInihinasingyrrnktcss 167
gi 291411875  87 IWMVTSHFSIWLATSLSIFYFLKIANFsnsIFHYLKWRVEKVISVTLLVSLVILFLNIAFLntdtdvwvagykrnvtnss 166
gi 504182600  88 SRIVSSHFSIWFATSLSIFYFLKIAMFsnsVFLYFKWRVKKVVMVTMLVSLGLLFSNIALSnmkielwfkghkdnktsss 167
gi 585668632  88 AWTVSNHFSLWFATNLSIFYFLKIATFsnpIFLYLKWRVKKTISFLFLMVLLFWCFNTALIniqlniwineheknmtysl 167
gi 504182603  88 AWIVTCHFSIWFATSLSLFYFLKIASFsnsVFLYLKWRVEKVVSVTLLLSLLLLLCNIVQAnieigiriklhkrnmtldh 167
gi 504182588  88 IWVMTNHFSVWLTASLSIFYLFKTANFtssVFLYLKRRVEKLVAVTLLISLVLLFLNIAVTstfndvskrnl----tyss 163
gi 504182611  90 SWAVTNHFNIWFATSLSIFYFFKIVNFsnsTFLYLKLRVEKVVSTTLLFSLVLLFVHVAILntqmnayiggcernmtcrc 169
gi 504182597  99 AWTISNHFSVWFATSLGIFYFLKIAYFsnsIFLYLQWRVKKVISVMLLMSLFFLFLNVAWTniyaelwierhkenmtlns 178
gi 655888608  88 TWIVTNHFSMWLATSLSIFYFLKIANFsnsTFLFLKWRVEKVILVTLFMSVVLLIFNIAMTnthidvwvevyr--gnlsy 165
gi 504182594  88 IGILINHISMWLATSLSVFYFLKIANFshdTFLFLKRRVEKVVSVMLFVSLVLLILHIAASniyigvwmgvyr--gnisn 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 29839658  168 dssnftrFSSLIVLTSTVFIFIPFTLSLAMFLLLIFSMWKHRKKMQhtvkisgDASTKAHRGVKSVITFFLLYAIFSLSF 247
gi 291411875 167 sskdslnFSRHFLLHYMIFTIIPFTLSLTAFILLIFSLWRHLRKKQlnataprDARTKAHLQGLQAVVAFLLLYTFFFLS 246
gi 504182600 168 slgefaqAFWIFLFTDTVFMMIPFTLSLITFLLLILSLWRHLRRLQvsatgsrDASSKAHLRCLQTMIVFLVLCTIFSLS 247
gi 585668632 168 mgsdfaqFASLTVWIIAIFTSIPFTVSLITFLLLIFSLWKHHKKMTlngkghrDVSSKAHIKAMQTVISFLLLYAVFFLS 247
gi 504182603 168 ismesahLFTILMSVESLFMVIPFTVSLTAFLLLIFSLWKHLRKMQlnaresrDASTKAHLKGLQTVIASNVLWIIFFLS 247
gi 504182588 164 ssrksvhISGIVVFSNMICTIFPFMVSLTTFFLLIFSLWRHLRKMQlkatglgDASTKAHLQGLQTVIAFLVLYTIFSLT 243
gi 504182611 170 nsneslyLSRLFLLTYLMSTIIPFTVSLITFLLLIHSLCRHLRKMHlsgmmskDTNTKAHLESLKIMVAFLLFYVVFFLS 249
gi 504182597 179 slsdsahFHGILLSIEMMFSVVPFSLCLLTYLLLFFSLGRHLRKMRinvtasgDSSTKAHVKCLLIFFVLLVLRTLFFLF 258
gi 655888608 166 tlshyahLFRKFLCIETIFVMIPFTLSLTTFLLLIYSLWRHLNKMQlnatgsrDTSSTAHVRGLQTVITFLALYTIFFLA 245
gi 504182594 166 mwspsthAFKNFLCIETMFTFIPFSLSLIAFLLLIFSLWRHLKNVQltasgsrDARTKAHVQGLQIVVMFLILYTIFFLM 245
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
Feature 1                                                          
gi 29839658  248 FISVwt--seRLEENLIILSQVMGMAYPSCHSCVLILGNkKLRQASLSVL 295
gi 291411875 247 LLIQvlisdlQEKNVIISLCHVLAMAFPSGHSYILILRNkKLRQASLSML 296
gi 504182600 248 LLLQiwsfalKGRYLITMVSQVFSILYPSGHSCVLILTNnKLRQASLHTL 297
gi 585668632 248 YFIPvwrfhsQKRIILSILSQVLALFYPSGHSILLILGNkKLKQTFLSVV 297
gi 504182603 248 ILVLtwspelQEKHLIIMVFYVFAMSYPSGHSCILILGNrKLKLASLSVL 297
gi 504182588 244 LLLQvwsrklLENILSNMVCQIFSMTYPSGHSYLLILRStKLRRVSLLVL 293
gi 504182611 250 VVIQvwavelLEKRLIAVALQILELTFSSGHSCILILGNkKLKQTLLVVL 299
gi 504182597 259 LLLQnwnavlVENQLISMVAQVFAMSYPSGHSWVLILGNsKLRRASVTAL 308
gi 655888608 246 LLLQtwntnlLENHLSFLVCQSLEMFYPSGHSCFMILGNrKLRQASLSVL 295
gi 504182594 246 LLLQmwntylGHSHLRIILCSIFGMIYPSGHSCVMILGNnKLRQASLAVL 295

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