Conserved Protein Domain Family
7tm_TAS2R3

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cd15020: 7tm_TAS2R3 
mammalian taste receptor 2, subtype 3, member of the seven-transmembrane G protein-coupled receptor superfamily
This group includes the mammalian taste receptor 2 (TAS2R) subtype 3, which functions as a bitter taste receptor. The human TAS2R family contains about 25 functional members, which are glycoproteins and have the ability to form both homomeric and heteromeric receptor complexes. Five basic tastes are perceived by animals: bitter, sweet, sour, salty, and umami (the taste of glutamate, MSG). Among these, sour and salty are mediated by ion channels, while the perception of umami and sweet tastes is mediated by the TAS1R taste receptors, which belong to the class C GPCR family. The TAS2Rs in humans have a short extracellular N-terminus and the ligand binds within the transmembrane domain, whereas the TAS1Rs have a large N-terminal extracellular domain composed of the Venus flytrap module that forms the orthosteric (primary) ligand binding site. Signal transduction of bitter taste involves binding of bitter compounds to TAS2Rs linked to the alpha-subunit of gustaducin, a heterotrimeric G protein expressed in taste receptor cells. This G-alpha subunit stimulates phosphodiesterase and decreases cAMP and cGMP levels. Further steps in the signaling cascade is still unknown. The beta-gamma-subunit of gustducin also mediates bitter taste transduction by activating phospholipase C, which leads to an increased formation of IP3 (inositol triphosphate) and DAG (diacylglycerol), thereby causing release of Ca2+ from intracellular stores and enhanced neurotransmitter release.
Statistics
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PSSM-Id: 320148
View PSSM: cd15020
Aligned: 8 rows
Threshold Bit Score: 355.931
Threshold Setting Gi: 89111402
Created: 13-Nov-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:TM helix 1 [structural motif]
Evidence:
  • Comment:All members of this receptor family contain a seven-transmembrane helix domain.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         ##########################                                                     
gi 114152888   7 GVFLILSGTQFTLGILVNCFIELVNGSSWFKtkrMSLSDFIITTLALLRIILLCIILTDSFLIEFspnthdsgiiMQIID 86
gi 89111402    7 IVYLVLFIIEFILGFCCNSFIGLVNCINCIKskrMTSSDLIITSLALSRICLLWVPIVNILQLLYpnly--ekkiLGIIV 84
gi 89111388    7 NFFLLMAFIEFILGILGNGFLGLINCIHWVKsskISLSDLIIMNLAFSRIILQCVISLDGVVLVFypsiydsekfIQIRE 86
gi 81863545    7 GIFLVLTVTEFILGNLVNGFIVSVNGSHWFKskkISLSDFIITSLALFRIFLLWIIFTDSLIIVFsyhthdsgirMQLID 86
gi 89111392    7 LGVLFVASTELFLGTWLNGFIMLLHCITWVRtrkISLSDFIILNLALSRFILQGIPIMDIILQVFyphfhgisifMRIID 86
gi 395541373   1 MVAFFLACSEFFLGTWVNGSTILLFCLTWVKsrkISFPDFIMLNLTLSRIILQGILILDSVLVAFyphlheggivMQIID 80
gi 395541369   7 IFFMLMTLCELILGIWGNGFLGFFNCIHWIKrnkISLSDFIIMNLAFTRVILHFVVTFDSTVLMLgpdffcemklMAIRD 86
gi 395541367   7 ILCVVVTISESLLGIGCNGFICLVNCINLIKskkMSLSEFLITSLTISRIFFLCIIVADVFMIFYfdse--itrgMQIFS 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 114152888  87 VSWTFTNHLSIWLATCLGVLYCLKIASFSHpTFLWLKWRVSRVMVWMLLGALLLSCGSTASLinefklysvfrgieatrn 166
gi 89111402   85 IIWIFINHLSTGLVTGLSVHYCLKIARYSHsAFLWLKWRVSCVVIWILLGSVLFSFFSVAPVikelivsfssrq-----m 159
gi 89111388   87 IGWTFSNYLSIWLVTCLSVFYCLKIAIFSHpAFLWLKWRVSQVVAWILFFSVLFSLFNIVSLirkfsmysdflkmkhien 166
gi 81863545   87 VFWTFTNHFSIWLISCLSVFYCLKIATFSHpSFLWLKWRASRVVVGMLWGALVLSCVCTMSLmnefkiysaltgsrdtqn 166
gi 89111392   87 IFWVFANNLSICLTTCLSVFYCLKIANFSHqAFLWLKWRVSHVVIWSLLGSVPYSFFSTLALilkfnvysnlnqikllgn 166
gi 395541373  81 IFWTFFNNLSTCLMACLSVLYCLKIANFSHhVFLWLKWRVSRVMVWILLGSGLYSFFSIMALlvkfsfysnrnls---en 157
gi 395541369  87 ACWTFSNYLNIWLSTCLSVFYCLKIAVFSHpAFFWLKRRISQVTAGILLVCVLFFFFNTVLMiqkyyisfallkmrliin 166
gi 395541367  85 LLWIFANFLSIWLATCLSILYCLKIANFSHrVFLWLKWRVFYVVKGILLVSVLFSFFSTLAMlkgfdstfrsaqmtctan 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 114152888 167 vtehfrkkrsEYYLIHVLGTLWYLPPLIVSLASYSLLIFSLGRHtrqmlqngtssRDPTTEAHKRAIRIILSFFFLFLLY 246
gi 89111402  160 kfiancteniTKSYAFIFSAVWMVIPFVIILCSSLLLILSLRRHtqqmnnsitgsRDPNTEAHLKAARIIVSFLFLYILY 239
gi 89111388  167 cteisrrkemEYYNAQIIGLLWSVIPFIISLISYFLLILSLKRHtrmlqhhitgpRDMSSEAHVKATKVMFSFLLLFVFY 246
gi 81863545  167 mteyirlkrhEYNLMHVLGNLWKIPSLIVSLIAYFLLLLSLGKHtqqmqkysvgsRDQSAEAHRRAMRIILSFLLFFLFY 246
gi 89111392  167 cteddkrkiiGYFVLYILSALYSIIPLFLSLVSSILLILSLVRHtrqmqhhasgtRDLSTMAHVRATKAILSSLLFLFGY 246
gi 395541373 158 ntavfkrkktEYYVLHVLGALWSVIPFSVCLVSSGLLILSLMRHtqqmqqytpgtRDLSTRAHIKATKIIFFSLLLFTGY 237
gi 395541369 167 ytenvrrkerESYVFHFLSFLWTLVPFIISLFSCLLLILSLKRHtrvmghhttapRDMSTTAHVRATKVIFSYLLLFVFY 246
gi 395541367 165 ctkdireqqsILFYTYISMALCMVIPFIVSLISYILVILSLRRHtqqmqnngigsRDPSTEAHVRATKITLSFVFLFIMY 244
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
Feature 1                                                          
gi 114152888 247 FLAFLIAsfgnflPKTKMAKMIGEVMTMFYPAGHSFILILGNsKLKQTFV 296
gi 89111402  240 FVAFFILifsdylPDYNLALMIGEMITTAYPSAHSFILILSNnKLKQAFL 289
gi 89111388  247 LIIMYIGssnfflTDTKLSIMIIELAAPLYPSVHSFILILQNkNLKQEFL 296
gi 81863545  247 FLSFVILsssrflPETKIARIIGVVITMSYLVGDSLILILGNnKLKQTFV 296
gi 89111392  247 FLVFFLAmsshflPDPKLAGTTSILIFAANPSIQTFVLILENqKLKQAFL 296
gi 395541373 238 IFALFLGmsshffPNPKLAGLTGALIFAAYPSFQTFILILENqKLKQAFL 287
gi 395541369 247 FVIQFIGtstillKDAKVMIMIVELVAPVYPSVHSFILILQNkTLKEAFL 296
gi 395541367 245 LVAFFIIilgfflPDIKLAWMTGELILAAHPSVHSIILIFVNnKLKQAFL 294

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