Conserved Protein Domain Family
7tm_TAS2R7-like

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cd15023: 7tm_TAS2R7-like 
mammalian taste receptor 2, subtypes 7 and 9, member of the seven-transmembrane G protein-coupled receptor superfamily
This group includes the mammalian taste receptor 2 (TAS2R) subtypes 7 and 9, which function as bitter taste receptors. The human TAS2R family contains about 25 functional members, which are glycoproteins and have the ability to form both homomeric and heteromeric receptor complexes. Five basic tastes are perceived by animals: bitter, sweet, sour, salty, and umami (the taste of glutamate, MSG). Among these, sour and salty are mediated by ion channels, while the perception of umami and sweet tastes is mediated by the TAS1R taste receptors, which belong to the class C GPCR family. The TAS2Rs in humans have a short extracellular N-terminus and the ligand binds within the transmembrane domain, whereas the TAS1Rs have a large N-terminal extracellular domain composed of the Venus flytrap module that forms the orthosteric (primary) ligand binding site. Signal transduction of bitter taste involves binding of bitter compounds to TAS2Rs linked to the alpha-subunit of gustaducin, a heterotrimeric G protein expressed in taste receptor cells. This G-alpha subunit stimulates phosphodiesterase and decreases cAMP and cGMP levels. Further steps in the signaling cascade is still unknown. The beta-gamma-subunit of gustducin also mediates bitter taste transduction by activating phospholipase C, which leads to an increased formation of IP3 (inositol triphosphate) and DAG (diacylglycerol), thereby causing release of Ca2+ from intracellular stores and enhanced neurotransmitter release.
Statistics
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PSSM-Id: 320151
View PSSM: cd15023
Aligned: 4 rows
Threshold Bit Score: 384.899
Threshold Setting Gi: 344266618
Created: 21-Jan-2014
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:TM helix 1 [structural motif]
Evidence:
  • Comment:All members of this receptor family contain a seven-transmembrane helix domain.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         ##########################                                                     
gi 29839663    7 TTLLFLAVGEFSVGILGNAFIGLVNCMDWVKkrkIASIDLILTSLAISRICLLCVILLDCFILvlypDVYATGkeMRIID 86
gi 83305806    7 TTLMFVAVCEALVGILGNAFIALVNFMGWMKnrkITAIDLILSSLAMSRICLQCIILLDCIILvqypDTYNRGkeMRIID 86
gi 344266618   7 VIYMILIAGELAIGIWGNGFIVMVNCIGYLKrrdIALVDIILIGLASSRIFLLCVISLDGFVMvlfpDTYTDGelMSILD 86
gi 29839661    7 AIYIILIAGELTIGIWGNGFIVLVNCIDWLKrrdISLIDIILISLAISRICLLCVISLDGFFMllfpGTYGNSvlVSIVN 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 29839663   87 FFWTLTNHLSIWFATCLSIYYFFKIGNFfhPLFLWMKWRIDRVISWILLGCVVLSVFISLPAtenlnadfrfcvkakrkt 166
gi 83305806   87 FFWTLTNHLSVWFATCLSIFYFFKIANFfhPLFLWIKWRIDKLILRTLLACLILSLCFSLPVtenltddfrrcvktkeri 166
gi 344266618  87 VLWTFSNYSSIWLTSCLSIFYLLRIANIshPIFLWLKQNVNRVILGILLGSLVLSLLISVSIsfhlhddfrylfkdnnee 166
gi 29839661   87 VVWTFANNSSLWFTSCLSIFYLLKIANIshPFFFWLKLKINKVMLAILLGSFLISLIISVPKnddmwyhlfkvs---hee 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 29839663  167 nltwscrvnKTQHASTKLFLNLATLLPFCVCLMSFFLLILSLRRHIRrmqlsatgcrDPSTEAHVRALKAVISFLLLFIA 246
gi 83305806  167 nstlrcklnKAGYASVKVNLNLVMLFPFSVSLVSFLLLILSLWRHTRqmqlnvtgynDPSTTAHVKATKAVISFLVLFIV 246
gi 344266618 167 nitlefevsKTQNALQQVFLNLGAVVPFILSLISFLLLLFSLFRHTKqmklhatgsrDPSTEAHMRAIKAVLIFLLLLVM 246
gi 29839661  164 nitwkfkvsKIPGTFKQLTLNLGVMVPFILCLISFFLLLFSLVRHTKqirlhatgfrDPSTEAHMRAIKAVIIFLLLLIV 243
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
Feature 1                                                           
gi 29839663  247 YYLSFLIAtssyfmPETELAVIFGESIALIYPSSHSFILILGNnKLRHASL 297
gi 83305806  247 YCLAFLIAtssyfmPESELAVIWGELIALIYPSSHSFILILGNsKLKQASV 297
gi 344266618 247 YYIAFLVVtssfliPQRKLVVMFGGIITIIFPSSHSFILIMGNsKLRKAFL 297
gi 29839661  244 YYPVFLVMtssaliPQGKLVLMIGDIVTVIFPSSHSFILIMGNsKLREAFL 294

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