Conserved Protein Domain Family
7tm_TAS2R38

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cd15025: 7tm_TAS2R38 
mammalian taste receptor 2, subtype 38, member of the seven-transmembrane G protein-coupled receptor superfamily
This group includes the mammalian taste receptor 2 (T2R) subtype 38, which functions as a bitter taste receptor. Genetic variants of human TAS2R38 influence the ability to taste synthetic compounds 6-n-propylthiouracil (PROP) and phenylthiocarbamide (PTC). Thus, sensitivity to the bitter taste of PROP is often used as a marker for individual differences in taste perception that can affect food preferences and intake. The human TAS2R family contains about 25 functional members, which are glycoproteins and have the ability to form both homomeric and heteromeric receptor complexes. Five basic tastes are perceived by animals: bitter, sweet, sour, salty, and umami (the taste of glutamate, MSG). Among these, sour and salty are mediated by ion channels, while the perception of umami and sweet tastes is mediated by the TAS1R taste receptors, which belong to the class C GPCR family. The TAS2Rs in humans have a short extracellular N-terminus and the ligand binds within the transmembrane domain, whereas the TAS1Rs have a large N-terminal extracellular domain composed of the Venus flytrap module that forms the orthosteric (primary) ligand binding site. Signal transduction of bitter taste involves binding of bitter compounds to TAS2Rs linked to the alpha-subunit of gustaducin, a heterotrimeric G protein expressed in taste receptor cells. This G-alpha subunit stimulates phosphodiesterase and decreases cAMP and cGMP levels. Further steps in the signaling cascade is still unknown. The beta-gamma-subunit of gustducin also mediates bitter taste transduction by activating phospholipase C, which leads to an increased formation of IP3 (inositol triphosphate) and DAG (diacylglycerol), thereby causing release of Ca2+ from intracellular stores and enhanced neurotransmitter release.
Statistics
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PSSM-Id: 320153
View PSSM: cd15025
Aligned: 5 rows
Threshold Bit Score: 396.514
Threshold Setting Gi: 89111432
Created: 21-Jan-2014
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:TM helix 1 [structural motif]
Evidence:
  • Comment:All members of this receptor family contain a seven-transmembrane helix domain.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         ##########################                                                     
gi 68068016   16 STFLFISVLEFAVGFLTNAFVFLVNFWDVVKrqaLSNSDCVLLCLSISRLFLHGLLFLSAIQLTHFQklseplnhsYQAI 95
gi 41018279   16 ISFLFLSAMEFAVGILANAFIVLVNVWDVVKkqpLNNCDIALLCLSITRLFLQGLLLLDAIQLACFQqmkdplshnYQAI 95
gi 89111432   16 WIYFSLSILELAIGILSNAFIVLVNAWDLVRrhqLSKFDSVLLCLGASRIFLQILLFMDALHLTHFQvmrdplsikYKTV 95
gi 81908162   16 ISFLFLSVVEFAVGIMANAFIVLVNFWDMVKkqpLNNCDIALLCLSITRLFLQGLLLLDAIQLACFQqmkdplshnYQAI 95
gi 655886792  16 ITFMVLSVLEFAVGVLANAFIFWVSFWDVVEqqpVNSCDLVLLCLSTTRLLPHGLLFLDAVHLSFFQqtkdplshsYQIV 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 68068016   96 IMLWMIANQANLWLAACLSLLYCSKLIRFshtFLICLASWVSRKISQMLLGIILCSCICTVLCVWCFFsrphftvttvlf 175
gi 41018279   96 LTLWMIANQVSLWLAACLSLLYCSKIVRFshtFPLHVASWVSRRFLQMLLVVLLLSCICTALCLWDFFcrshstvtsllh 175
gi 89111432   96 ILFGMLVNQTSLWLATWLSILYCAKIARVshaFLIWLKGWLLMTIPQLLLGSLIFPWLSFFPCIWKHFslsysnstvsfs 175
gi 81908162   96 LTLWMSANQVSLWLAACLSLLYCAKIVRFshtFPLHLASWVSRRFLQMLLVALLFSGVCTALCLWDFFsrshtvvtsmlh 175
gi 655886792  96 IMLWTIRNQVSLWLPTCLSPLHCSKVARFshtFLLCVASWISRRTPQLLLGGLLFCCIRTVLCVGDFRvasvllvnnx-- 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 68068016  176 mnnntrlnwqikdlNLFYSFLFCYLWSVPPFLLFLVSSGMLTVSLGRHMRTMKvytrnsrDPSLEAHIKALKSLVSFFCF 255
gi 41018279  176 l-nstefslqiaklNFFYSFIFCNVGSVPPSLAFLVSSGVLVISLGSHMRTMKsqtsssgDPSLEAHIRAIIFLISFFCF 254
gi 89111432  176 --gnitensikerfIFFHFFLLCNLGNIFPFLLFLASSSILIISLGRHMRTMTaqttgsgDPSLEAHIIALRSLISFLLL 253
gi 81908162  176 m-nntefnlqieklNFFYSFVFCNVGSVPPSLVFLISSGVLVISLGNHMRTMKsqtrgsrDPSLEAHVRAIIFLVSFLCF 254
gi 655886792 174 -----elnvhigsvSLFYVFMFCSVGSIPLFLSFLVSSGVLIVSLRKHLRTMMaqasnvrDPSPEAHIQALKALVALICF 248
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
Feature 1                                                              
gi 68068016  256 FVISSCAAFISVPllilWRDKIGVMVCVGIMAACPSGHAAILISGNaKLRRAVM 309
gi 41018279  255 YVVSFCAALISIPllmlWHNKGGVMICIGMMAACPSGHAAILISGNaKLRRAIE 308
gi 89111432  254 YVIGFVATLAAVPftllISSKIGVMVCVGIMLTSPSVHSIILILSNnKLKRVLK 307
gi 81908162  255 YVVSFCAALISIPllvlWHNKGGVMVCIGMMAACPSGHAAILISGNaKLKKVIV 308
gi 655886792 249 YVVLFCTAVIXAVlt-eWHNKTGAMVCDVLLAACPSGHAAVLISSNaKLRRTVD 301

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