Conserved Protein Domain Family
7tm_TAS2R43-like

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cd15027: 7tm_TAS2R43-like 
mammalian taste receptor 2, subtype 43, and related proteins, member of the seven-transmembrane G protein-coupled receptor superfamily
This group includes the mammalian taste receptor 2 (T2R) subtype 43, which functions as a bitter taste receptor. Also included are the closely related taste receptors TAS2R19, TAS2R20, TAS2R30, TAS2R31, TAS2R45 and TAS2R50. The human TAS2R family contains about 25 functional members, which are glycoproteins and have the ability to form both homomeric and heteromeric receptor complexes. Five basic tastes are perceived by animals: bitter, sweet, sour, salty, and umami (the taste of glutamate, MSG). Among these, sour and salty are mediated by ion channels, while the perception of umami and sweet tastes is mediated by the TAS1R taste receptors, which belong to the class C GPCR family. The TAS2Rs in humans have a short extracellular N-terminus and the ligand binds within the transmembrane domain, whereas the TAS1Rs have a large N-terminal extracellular domain composed of the Venus flytrap module that forms the orthosteric (primary) ligand binding site. Signal transduction of bitter taste involves binding of bitter compounds to TAS2Rs linked to the alpha-subunit of gustaducin, a heterotrimeric G protein expressed in taste receptor cells. This G-alpha subunit stimulates phosphodiesterase and decreases cAMP and cGMP levels. Further steps in the signaling cascade is still unknown. The beta-gamma-subunit of gustducin also mediates bitter taste transduction by activating phospholipase C, which leads to an increased formation of IP3 (inositol triphosphate) and DAG (diacylglycerol), thereby causing release of Ca2+ from intracellular stores and enhanced neurotransmitter release.
Statistics
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PSSM-Id: 320155
View PSSM: cd15027
Aligned: 44 rows
Threshold Bit Score: 354.192
Threshold Setting Gi: 507705748
Created: 21-Jan-2014
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:TM helix 1 [structural motif]
Evidence:
  • Comment:All members of this receptor family contain a seven-transmembrane helix domain.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1             ##########################                                                 
gi 374095447   3 TFLPIIFSSLVVVTFVIGNFANGFIALVNSIEWFKRqKISFADQILTALAVSRVGLLWVLLLNWYSTVLNpafnsvevRT 82
gi 41018281    3 SFLVSIASIAMLVKIVLGTFANVFIVLVNFTDCIKKrKFLLADRILTVLAIFRFDLLWIILMNWSSSVFHvgly-fqvRF 81
gi 291411869   3 SLLPIIISILVLAEFVLGNFANAFITLVICTDWVKRrKLSLVDWILVALAVSRIALLWVILIYWNATIVNptsynlsvIH 82
gi 291411867   3 NLFVCILYILMTVEFFLGNFANIFIALVNFIDWVKRqKLSSADRILTALTISRIALLWVTFMFLYSSMLNttsynvqvRI 82
gi 676269684 321 SLLCNILIIMIMAEFVIGNFANMFIALVNCTDWVKRrRISSTDQILTALAISRVGLICTLIANWFLIVFHqtay-skvRI 399
gi 348569120   3 SVLQSILTIVVTAVFVVGNFSNVFIAVVNCSDWVTRqRIYAVDGILTALAVSRIVLLWIMFIGWFSTMFNpvv---nsGI 79
gi 532092597   3 NVLANIASILIIVELVIGNFANVFIALVNCIDLINGqRISSADGILSALAVSRIGLLWAISINWYFTVFNsdiyrkqtEI 82
gi 507570179   3 SLLPTIVSIVIVVEFVLGNFANVFIALVNCVDCIKKrKISIVDKILTALGVSRTVWLWVILMNWSSTVFYpdsh-krqVK 81
gi 533129138   3 SAVQSILTIVVTAEFVVGNFANVFITLVNCTDWVKRkRISSVDRILTALAVSRIGLLWVMFLSWSFTLFNpal---ksGM 79
gi 655902582   3 SLLLRFLSIPVMAEFVLGNFANCFIALVNCIDWVKKkKFSFVDGILTALAVSRIVLLWMILMHWDLTTFNaa----sySI 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 374095447  83 TAYNIWAVINHFSNWLATTLSIFYLLKIANFsnFIFLHLKRRVKSvILVMLLGPLLFLACHLFVInmneivrtKEFEGNM 162
gi 41018281   82 CICVVWIVTNHFNTWLANILSILYLLKIDNFsnLIFLGLKGKIKC-PYIVLLPCFVLLFPNLIMVticettqaNGHQGNL 160
gi 291411869  83 TVTVAWAVTNHFSVWLATSLSIFYLLKIANFsnLIFLHLKRNADKvILFVLPGSFVVFFCYLSVKnmewivrmSENEGNV 162
gi 291411867  83 IFNITGVVCNHFSTWFATLLSIFYLLKIANFhnFIFLHLKKNINLvISVVLLGSSVFLFYYLAVMsveeimwvNECERNV 162
gi 676269684 400 TLRIFWSVSNHFGSWLATALSIFYVLKITNFsnFIFLYLKRKVNRvSPVTVLGTLVLLPFDLTVTlvydtmevKGYLGNV 479
gi 348569120  80 TSHVLYTIVNHFSTWIATSLSIFYLFKIANFssHIFLQLKKRVKGvFVSTMVVCLILLLYTFVIIsmnettkmKEHEGNV 159
gi 532092597  83 IIRIAWAVTNHLSTWLATSLSIFYLLKIANFsnFVFLYLKKKERSvILVIMLGTLMLLFPHLVIAsiletmqmNENIGNV 162
gi 507570179  82 FITVAWAVANHFSVWFATTLSIFYLLKIPNFsnRIFLYLQQKVKHvIVAVLLSMLILLFSNFTMAnvcmmmqvSVHGGNV 161
gi 533129138  80 IAHFFWTITNHFSTWIATSLSVFYLLKIASFsnLIFLHLKKRGNNiIVLILLWCLVLLVSKLVISvydi-tglKEHKGNL 158
gi 655902582  79 AYEVGWLVAHYFSIWFATILSIFYVLKVANFstIIFLHLKKNINGvILVVLLGSLLFFLCYLAMInmsdrpwvSEYEGNT 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 374095447 163 TWKIKlksaMYFSNMTVTMVANLVPFTLTLLSFMLLICSLCKHLKKMqlhgkgsqDPSTKVHIKALQTVISFLLLCAIYF 242
gi 41018281  161 TGKTKlt-yFTNLIAMTFTLGSLVPFTTFMICFLLLICSLCKHLRTMrlygkgsqGPSASTHIKVLQVLISFLLLFSMFI 239
gi 291411869 163 TWKTDllsiLHISDLSLLTITNLIPFTTSLICFLLLIYSLCKHLRKMqlhgrrlqDPSTKVHVKALQTVISFLLLFVIYF 242
gi 291411867 163 TQKTNltgiLHLSNMAVLTMLNLTPFTTSLLCFLLLICSQSKHVRKMqlhgkgpqDLSTKAHIRALQLIFSFLLLFSIYT 242
gi 676269684 480 TWKLKlkdaIHSSKRTIFTLVNLLPFLTCLICVLLLISSLRSHLRKMqlygkgsqDPSTKVHVKVLQTAASFVMLYAMYS 559
gi 348569120 160 TWKTElgttVYLSFLSGGTLVHLIPFIISIVCGLLLTYSLCRHLSHMrqhskgsqDPSTEVHVKALKTVVSYLLLFAMYS 239
gi 532092597 163 TQNTKlkdiTNFLNMTAFTLLNSIPFFISLICVLLLIYSLCKHLRRMrlhgkgsqDPSTKVLVKALQTVISFLLLLALYF 242
gi 507570179 162 TGVIQlsdtARLTVVIFSTLSNAIPFMVSLICLLLLIYSLCKHVRKMklhgkgsqDPSTAVHMKAVYTVVSFLLLLLMNF 241
gi 533129138 159 TWKRElgntVYLPIRGALTVVYFIPIIISIVCFLLLIYSLRKHLRQMhqhskgsqDISTEVHVKALKTVISHLLLLIMYC 238
gi 655902582 159 AWKTNltdiEQVLKLSMVTMANLIPFITSLICLLLLIYSQCKHIRKMqfhgqrsqDPSTKVHVKAIQTVLSFLLLFAFYF 238
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
Feature 1                                                            
gi 374095447 243 LSIMISvwsfgsLENKPVFMFCKAIRFSYPSIHPFILIWGNkKLKQTFLSVF 294
gi 41018281  240 LLLIISdynytkSLEEPIHLICQVIGTLYPSRHSYILLWGNkRIKQAFVLAM 291
gi 291411869 243 LSVIISvwsykrQKNVPVFSLGQAIELIYPLSHSVVLIFGNrKLKEAFLLLV 294
gi 291411867 243 VSIIASvwrfneLQNKPLLFLWQVCALIYPSSHSFLLIWGNkKLTQTFLSML 294
gi 676269684 560 LSVITSdwwleySWNKPVYLFSLATEILYPLGHSCVLIWANkKLKQAFLLVL 611
gi 348569120 240 VSIIISgwsfnwFRNETVYLLSQTLAIMYPSSHSCVLIWGNrKLKQAFMLRV 291
gi 532092597 243 VSLTISg----wNSKKPVMLLCHAAGLLYPSSHSFVLIWGNkKLKETFVSVF 290
gi 507570179 242 LSLITSlwysnkPLAEPVHLLCQAIGVLYPSSHSYVLIWGNkKLKQAFLLAR 293
gi 533129138 239 LSILIShwnftiLQNESVFLLSKITVILYPSSHSCILIWGNrKLKQAFMLGV 290
gi 655902582 239 LVITVSvwyfkgQHSRLLLLLSHVFASSFPSIHSFVLIWGNrKLNRAFLLMW 290

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