Conserved Protein Domain Family
7tmF_FZD3

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cd15033: 7tmF_FZD3 
class F frizzled subfamily 3, member of 7-transmembrane G protein-coupled receptors
This group includes subfamily 3 of the frizzled (FZD) family of seven transmembrane-spanning proteins, which constitute a novel and separate class of GPCRs, and its closely related proteins. This class F protein family consists of 10 isoforms (FZD1-10) in mammals. The FZDs are activated by the wingless/int-1 (WNT) family of secreted lipoglycoproteins and preferentially couple to stimulatory G proteins of the Gs family, which activate adenylate cyclase, but can also couple to G proteins of the Gi/Gq families. In the WNT/beta-catenin signaling pathway, the WNT ligand binds to FZD and a lipoprotein receptor-related protein (LRP) co-receptor. This leads to the stabilization and translocation of beta-catenin to the nucleus, where it induces the activation of TCF/LEF family transcription factors. The conserved cytoplasmic motif of FZD, Lys-Thr-X-X-X-Trp, is required for activation of the WNT/beta-catenin pathway, and for membrane localization and phosphorylation of Dsh (dishevelled) protein, a key component of the WNT pathway that relays the WNT signals from the activated receptor to downstream effector proteins. The WNT pathway plays a critical role in many developmental processes, such as cell-fate determination, cell proliferation, neural patterning, stem cell renewal, tissue homeostasis and repair, and tumorigenesis, among many others.
Statistics
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PSSM-Id: 320161
View PSSM: cd15033
Aligned: 5 rows
Threshold Bit Score: 679.362
Threshold Setting Gi: 171847297
Created: 14-Nov-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to Human smoothened receptor bound to an antitumor agent.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         #        #                                                 #                   
gi 117938968 204 MYFRREELTFARYFIGVVSIVCLSATLFTFLTFLIDVTRFRYPERPIIFYAVCYMMVSLVFFLGFLLEDRVACNsanpgq 283
gi 17433025  192 MYFRREELSFARYFIGLISIICLSATLFTFLTFLIDVTRFRYPERPIIFYAVCYMMVSLIFFIGFLLEDRVACNasspaq 271
gi 17432977  191 MYFRREELSFARYFIGVISIVCLSATLFTFLTFLIDVTRFRYPERPIIFYAVCYMMVSLIFFIGFLLEDKVACNganpsq 270
gi 483507552 192 MYFRREELSFARYFIGVISIVCLSATLFTFLTFLIDVTRFRYPERPIIFYAVCYMMVSLIFFIGFLLEDRVACNasspaq 271
gi 171847297 194 MYFRKDELIFARYFIGVISIVCLSATLFTFLTFLIDVGRFRYPERPIIFYAVCYMMVSLVFFLGFLLEDRVSCNtaspgr 273
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         #                                                                              
gi 117938968 284 yKTSTVTQGsHNKACTLLFMVLYFFTMAGSVWWVILTITWFLAAVPKWGsEAIEKKALLFHASAWGIPGMLTIALLALNK 363
gi 17433025  272 yKASTVTQGsHNKACTMLFMVLYFFTMAGSVWWVILTITWFLAAVPKWGsEAIEKKALLFHASAWGIPGTLTIILLAMNK 351
gi 17432977  271 yKASTVTQGsHNKACTMLFMVLYFFTMAGSVWWVILTITWFLAAVPKWGsEAIEKKALLFHASAWGIPGTLTIILLAMNK 350
gi 483507552 272 yKASTVTQGsHNKACTMLFMVLYFFTMAGSVWWVILTITWFLAAVPKWGsEAIEKKALLFHASAWGIPGTLTIILLAMNK 351
gi 171847297 274 fRASTITQGsHNKACTLLFMTLYFFTMAGSVWWVILTITWFLAAVPKWGsEAIEKKALLFHAVAWGVPGALTITLMAMNK 353
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1           #    # #  ##    #                                                            
gi 117938968 364 IEGDNISGVCFVGVYDVQTLRWFVLAPLCLDVLVGVSLLLAGIVALNRVRMEIPlekENQEKLVKFMIRIGVFSVLYLVP 443
gi 17433025  352 IEGDNISGVCFVGLYDVDALRYFVLAPLCLYVVVGVSLLLAGIISLNRVRIEIPlekENQDKLVKFMIRIGVFSILYLVP 431
gi 17432977  351 IEGDNISGVCFVGLYDVHALRYFVLAPLCLDVVVGVSLLLAGIISLNRVRIEIPlekENQDKLVKFMIRIGVFSILYLVP 430
gi 483507552 352 IEGDNISGVCFVGLYDVDALRYFVLAPLCLYVVVGVSLLLAGIISLNRVRIEIPlekENQDKLVKFMIRIGVFSVLYLVP 431
gi 171847297 354 IEGDSMSGVCFVGLYDLMALRWFLLVPLVLDVIVGVVLLLAGIAALNRVRMEIPlekENQDKLVKFMIRIGVFSVLYLVP 433
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                      #  ##                        #    #  ##                           
gi 117938968 444 LLTVVGCYLYEQTYRSvWETTWVQErCREYHIPCPfkveqtSRPDLVLFLIKYLMVLVVGIPSVFWVGSKKTCFEWAGFF 523
gi 17433025  432 LLVVIGCYFYEQAYRGiWETTWIQErCREYHIPCPyqvtqmSRPDLILFLMKYLMALIVGIPSIFWVGSKKTCFEWASFF 511
gi 17432977  431 LLVVIGCYFYEQAYRGvWETTWVQErCREYHIPCPykvtqtSRPDLILFLMKYLMLLVVGIPSVFWVGSKKTCFEWASFF 510
gi 483507552 432 LLVVIGCYFYEQAYRGvWETTWIQErCREYHIPCPyqvtqmSRPDLILFLMKYLMALVVGIPSVFWVGSKKTCFEWASFF 511
gi 171847297 434 LLTVIGCYLYEQSHRSvWETTWVQErCREYHIPCPfkvektSRPDIALFLIKYLMMLVVGIPSVFWVGSKKTSTQGTSTH 513

                 .
Feature 1         
gi 117938968 524 H 524
gi 17433025  512 H 512
gi 17432977  511 H 511
gi 483507552 512 H 512
gi 171847297 514 A 514

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