Conserved Protein Domain Family
7tmF_FZD10

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cd15037: 7tmF_FZD10 
class F frizzled subfamily 10, member of 7-transmembrane G protein-coupled receptors
This group includes subfamily 10 of the frizzled (FZD) family of seven transmembrane-spanning proteins, which constitute a novel and separate class of GPCRs, and its closely related proteins. This class F protein family consists of 10 isoforms (FZD1-10) in mammals. The FZDs are activated by the wingless/int-1 (WNT) family of secreted lipoglycoproteins and preferentially couple to stimulatory G proteins of the Gs family, which activate adenylate cyclase, but can also couple to G proteins of the Gi/Gq families. In the WNT/beta-catenin signaling pathway, the WNT ligand binds to FZD and a lipoprotein receptor-related protein (LRP) co-receptor. This leads to the stabilization and translocation of beta-catenin to the nucleus, where it induces the activation of TCF/LEF family transcription factors. The conserved cytoplasmic motif of FZD, Lys-Thr-X-X-X-Trp, is required for activation of the WNT/beta-catenin pathway, and for membrane localization and phosphorylation of Dsh (dishevelled) protein, a key component of the WNT pathway that relays the WNT signals from the activated receptor to downstream effector proteins. The WNT pathway plays a critical role in many developmental processes, such as cell-fate determination, cell proliferation, neural patterning, stem cell renewal, tissue homeostasis and repair, and tumorigenesis, among many others.
Statistics
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PSSM-Id: 320165
View PSSM: cd15037
Aligned: 4 rows
Threshold Bit Score: 647.426
Threshold Setting Gi: 4585279
Created: 14-Nov-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to Human smoothened receptor bound to an antitumor agent.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #        #                                                 #                  #
gi 17433077 221 VYWSKDDKQFAVIWIAIWSILCFFSSAFTVLTFLIDPQRFKYPERPIIFLSMCYCVYSVGYIIRLFSgAESIACDrdsgQ 300
gi 17433043 222 VYWSKDDKKFAFIWIAIWSILCFFSSAFTVLTFLVDPLRFKYPERPIIFLSMCYCVYSVGYIIRLFAgADSIACDrdsgQ 301
gi 52782829 218 VYWSRDDKRFAVVWLAIWSVLCFFSSAFTVLTFLIDPSRFRYPERPIIFLSMCYCVYSVGYIIRLFAgAESIACDrdsgQ 297
gi 4585279  217 VYWSQGDKRFSMVWIAIWSILCFISSAFTVLTFLIDPQRFKYPERPIIFLSMSYCVYSVGFLVRLFVgVENVACDrdtgV 296
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
gi 17433077 301 LYVIQEGlESTGCTIVFLVLYYFGMASSLWWVILTLTWFLAAGKKWGhEAIEANSSYFHLAAWAIPAVKTIMILVMRrVA 380
gi 17433043 302 LYVIQEGlESTGCTIVFLILYYFGMASSLWWVILTLTWFLAAGKKWGhEAIEANSSYFHLAAWAIPAVKTIMILVMRrVA 381
gi 52782829 298 LYVIQEGlESTGCTLVFLVLYYFGMASSLWWVVLTLTWFLAAGKKWGhEAIEANSSYFHLAAWAIPAVKTILILVMRrVA 377
gi 4585279  297 QYIIQEGlESTGCTIVFLILYYFGMASSLWWVILTLTWFLAAGKKWGhEAIEANSSYFHLAAWAIPAIKTIMILVMRkVA 376
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #    # #  ##    #                                                              
gi 17433077 381 GDELTGLCYVGSMDVNALTGFVLIPLACYLIIGTSFILSGFVALFHIRRVMKtggENTDKLEKLMVRIGVFSVLYTVPAT 460
gi 17433043 382 GDELTGVCYVGSMDVNALTGFVLIPLACYLIIGTSFILSGFVALFHIRRVMKtggENTDKLEKLMVRIGVFSVLYTVPAT 461
gi 52782829 378 GDELTGVCYVGSMDVNALTGFVLVPLACYLVIGTSFILSGFVALFHIRRVMKtggENTDKLEKLMVRIGVFSLLYTVPAT 457
gi 4585279  377 GDELTGVCYVGSMDVKALTGFVLIPLSCYLIIGTSFLLSGFVALFHIRKVMKtegENTDKLEKLMVRIGVFSVLYTVPAT 456
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                   #  ##                         #    #  ##                            
gi 17433077 461 CVIACYFYERLNMDyWKIVASQQKCkmnnqtknldCMMNNSIPAVEIFMVKIFMLLVVGITSGMWIWTSKTLQSWQNVCS 540
gi 17433043 462 CVIACYFYERLNMDfWKILATQDKCkmdsqtktldCTMTSSIPAVEIFMVKIFMLLVVGITSGMWIWTSKTVQSWQNVFS 541
gi 52782829 458 CVIACYFYERLNMDyWKMLATQHKCkmnnqtktpdCLMTTSIPAVEVFMVKVSMLLVVGITSGVWVWTSKTLQSWQHVCS 537
gi 4585279  457 CVIACYFYERLNMDyWKILAGEQKCaddgk-sgeeCVMKSSIPAVEIFMVKIFMLLVVGITSGMWIWTSKTLQSWQNVFS 535

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