Conserved Protein Domain Family
7tmC_Boss

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cd15042: 7tmC_Boss 
Bride of sevenless, member of the class C family of seven-transmembrane G protein-coupled receptors
Bride of Sevenless (Boss) is a putative Drosophila melanogaster G protein-coupled receptor that functions as a glucose-responding receptor to regulate energy metabolism. Boss is expressed predominantly in the fly's fat body, a nutrient-sensing tissue functionally analogous to the mammalian liver and adipose tissues, and in photoreceptor cells. Boss, which is expressed on the surface of R8 photoreceptor cell, binds and activates the Sevenless receptor tyrosine kinase on the neighboring R7 precursor cell. Activation of Sevenless results in phosphorylation of the Sevenless, triggering a signaling transduction cascade through Ras pathway that ultimately leads to the differentiation of the R7 precursor into a fully functional R7 photoreceptor, the last of eight photoreceptors to differentiate in each ommatidium of the developing Drosophila eye. In the absence of either of Sevenless or Boss, the R7 precursor fails to differentiate as a photoreceptor and instead develops into a non-neuronal cone cell. Moreover, Boss mutants in Drosophila showed elevated food intake, but reduced stored triglyceride levels, suggesting that Boss may play a role in regulating energy homeostasis in nutrient sensing tissues. Furthermore, GPRC5B, a mammalian Boss homolog, activates obesity-associated inflammatory signaling in adipocytes, and that the GPRC5B knockout mice showed resistance to high-fat diet-induced obesity and insulin resistance.
Statistics
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PSSM-Id: 320170
View PSSM: cd15042
Aligned: 6 rows
Threshold Bit Score: 322.446
Threshold Setting Gi: 270015727
Created: 2-Feb-2014
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative allosteric modulator binding site [chemical binding site]
Evidence:
  • Comment:based on the binding of human mGluR1 receptor to a negative allosteric modulator FITM (contacts at 4A)

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                  #                     
gi 307177630 386 VYVPIFLIAVVCGTFACCVIVIFIVRRFTte-kRFDGNPTFTIVLVLANVFTLLTVLPFCmtdd------------yfgk 452
gi 307203845 477 VYVPICLVAVVCGTLMCCVTVVFIVYRFTteraELDGDPSLTIALILAIVFTLLTALPFCmadd------------yfga 544
gi 332024924 290 FYVPVFLIVIICGILVCCGMIIFIIYYTTak-eILHGNLVFTIVLVLANLFILLTALSFYmtdd------------yfga 356
gi 270015727 387 SWIFAFLSLSLLGVLFCIAILVFLLVSVCrk-nVLEGNPVLTILLLFTVMVMFCSIVPLSlegn------------rwak 453
gi 2827758   529 TWVATGLTAAILGLIATLAILVFIVVRISlg-dVFEGNPTTSILLLLSLILVFCSFVPYSieyvgeqrnshvtfedaqtl 607
gi 122117692 577 AWVAAGLTIASLGILFCLAILIFLIVRVCmd-dVLEGNPLSSILLLISLIFQFASFLPFSleytgympdllhkadtiytw 655
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1              ##  ##  #                                                                 
gi 307177630 453 TNLDARKILHTTLAFGFTFSIMLSRALFLAlstgd-vfiiHINGYLHSLMAFFMSGVQVAISVMYFVLNAkn-----svV 526
gi 307203845 545 ESLNARRILLATLAFGLTFSIMLSRALFLAlstgg-vlvsHVNGYLQSVMVFFMFAVQLAMSIMYFVLNTad-----saV 618
gi 332024924 357 ENLNAWKILLTTLAFGLTFSIMLSRALFLAlstgg-vfiiHINGYLQSLMALFACGVQIAMSIMYFVLSTmn-----saV 430
gi 270015727 454 RSICMARALSITLSFAAAFSLMLSRSIVLAtaskeigfmsHVAGPVQSFLCLFIFGVQAALSLQVFNHCE---------D 524
gi 2827758   608 NTLCAVRVFIMTLVYCFVFSLLLCRAVMLAsigseggflsHVNGYIQAVICAFSVVAQVGMSVQLLVVMHvasetvsceN 687
gi 122117692 656 NTLCTVKIFLLSVCYCTTFSLLLCRAIMLAsigseggflsHVNGYLQSVICIFSTLVQLGLSTQLVIVLHasshniscnE 735
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         #    #  ##  #                                 #  ##  #   #       ##  #  #   #  
gi 307177630 527 ITRSPIFIALLGYDIFLLISLFIASCFITKIQrNYYEGKCLFGTSTGLLVVWAIWLICFIlmqPENRDTVVSFGIIGTTY 606
gi 307203845 619 ITRSLVFIALLGYDIFLLIALFVACCFITGIRrNYHEGKCFFGTAVGLLAVWTGWLICFVlmqPESRDMIISFGVIGTAY 698
gi 332024924 431 VIRSLIFLALLGYDIFLLIALFVTCYFIIRIQhNYHEEKYFFGASIGLLVIWVIWLTCFIlmqPENRDAVIFFGTVATAY 510
gi 270015727 525 IFRGHSFIYILSYNIILLLLLLCFCPLIFKSQrNYREGKYFTFATIITSLLWCFWVPAYLllgDYYKDSVLCFGLVSTAS 604
gi 2827758   688 IYYGRWLWGLLAYDFALLCCVGALIPSIYRSQrNYREGILIVIGSVLIMVIWVAWIALSLf-gDEWRDAAIPLGLQASGW 766
gi 122117692 736 IYYGNWFWATIAYDGILLAALIVLSPYIFRSQrNYREGMLLVTGSILCLVIWTTWIPLCVf-gYEWREAAVSLGLVATAL 814
                        250
                 ....*....|....*.
Feature 1                        
gi 307177630 607 SIIFGILIPKIYYMIT 622
gi 307203845 699 SIILGTLVPRMYYMLM 714
gi 332024924 511 LIIFGVLVPRIYYITH 526
gi 270015727 605 VLLATIFVPRTYLMTI 620
gi 2827758   767 AVLVGILIPRTFLIVR 782
gi 122117692 815 AVLVGVMIPRCFLMVR 830

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