Conserved Protein Domain Family
7tmA_5-HT4

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cd15056: 7tmA_5-HT4 
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors
The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.
Statistics
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PSSM-Id: 320184
View PSSM: cd15056
Aligned: 9 rows
Threshold Bit Score: 406.105
Threshold Setting Gi: 229294304
Created: 13-Nov-2008
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                     #  
gi 12644029   20 VVLLTFLSTVILMAILGNLLVMVAVCWDRQLRkikTNYFIVSLAFADLLVSVLVMPFGAIELVqd-iWIYGevFCLVRTS 98
gi 229294304  11 VLLSSFLALVILLTIVGNILVISTVALFRSLRs-lTNYFVVSLAVADLLVGVIVMTLGTQYEVsg-rWRHGeiFCLIFTS 88
gi 483525120  12 IVLLTFISAVILMAILGNLLVMVAVCRDRQLRkikTNYFIVSLAFADLLVSVLVMPFGAIELVqd-nWIYGemFCLVRTS 90
gi 47216965   10 TVLSFFLSVIIVMTVFGNLLVMVALCKDRHLRrkkTNYFIVSLAFADLLVAVVVMPFAAIELTtg-hWRYGeiFCLVRTS 88
gi 405972155  57 VLIGLVLSLFPVLTLIGNVLVIVAVFTHKRLRt-iTNVFVVSLSVADALVAILVMPFAVYLQInnnqWDLGptICTIYTC 135
gi 327420566  64 ITISAILICVPILTVVGNWVVILAVITHRKLRt-iTNAFVVSLAVADMSVALFVMPFSIYQQLnnklWALGdtLCKLSSS 142
gi 513206414  20 IVLLTFISAVILMAILGNLLVMVAVCRDRQLRkikTNYFIVSLAFADLLVSVLVMPFGAIELVqd-nWIYGemFCLVRTS 98
gi 11321563   20 VVLLTFLSTVILMAILGNLLVMVAVCWDRQLRkikTNYFIVSLAFADLLVSVLVMPFGAIELVqd-iWIYGevFCLVRTS 98
gi 432880360   5 IALICFLSLVMLMSVLGNLLVMVAVCKDRQLRkikTNYFIVSLAFADLLVSVLVMPFGAIELVhq-hWIYGetFCLVRTS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         ##  ##                                                                         
gi 12644029   99 LDVLLTTASIFHLCCISLDRYYAICCQplvyrnkmtPLRIALMLGGCWVIPTFISFLPIMQGwnnigiidlie-krkfnq 177
gi 229294304  89 MDISLTTCSIMHLTPPRGIPHRKMVLM---------IAMCWVVPVIMAYVPIMNRWNTIGIEpvvedtk----------c 149
gi 483525120  91 LDVLLTTASILHLCCISLDRYYAICCQplvyrnkmtPLRIAVMLGGCWVIPTFISFLPIMQGwnsigiidliq-qrqfnk 169
gi 47216965   89 LDVQLTTASILHLCCIALDRYYAICCQplvyrhkmtPVRVAAMLSGCWLIPTFISFLPIMQSwntigiedliknrqasgg 168
gi 405972155 136 FDVMSTTSSIMHLSCLAVDRYLAICRPflhe--rlnNKIVATMVASCWVLPAIIAYIPILKKwnhigied-------yiy 206
gi 327420566 143 LDVMMCTVSIFHLSCLAVDRYLAICRPflhe--rltVRWVAIMLVFCWATPVFISFLPILNGwnhlgieqlv----acaf 216
gi 513206414  99 LDVLLTTASILHLCCISLDRYYAICCQplvyrnkmtPLRIAVMLGGCWVIPTFISFLPIMQGwnsigiidliq-qrqfnk 177
gi 11321563   99 LDVLLTTASIFHLCCISLDRYYAICCQplvyrnkmtPLRIALMLGGCWVIPTFISFLPIMQGwnnigiidlie-krkfnq 177
gi 432880360  84 LDVLLTTASILHLCCIALDRYYAICCQplvyrnkmtPMRVALMMGGCWVIPTFISFLPIMQGwnsigidhvie-errhsg 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                #      #  ##  #                                                         
gi 12644029  178 nsnstYCVFmVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAkehahqiqmlqragas---------------------- 235
gi 229294304 150 algpeSCVFlVNKEFSLIASTLSFYLPAVMMTLAYYQVYRAArrqmqqiisl---------------------------- 201
gi 483525120 170 asnstYCIFmVNKPYAITCSVVAFYIPFLLMVLAYYRIYITArehahqirvlqragtp---------------------- 227
gi 47216965  169 gsndtSCVFmVNTPYALICSTVAFYVPLALMVLAYQRIYVTAmahvrqietlqragsapvpgttptitvksstssdpleh 248
gi 405972155 207 clgdsVCALiVNIPFAIICSTIAFYIPAVFMIISNVKIYLAArtqarhirslea-------------------------- 260
gi 327420566 217 ppgapVCAFiVNTAFAVICSLIAFYIPVLFMGVCNVKIYMAAvqqahqirtlekag------------------------ 272
gi 513206414 178 asnstYCIFmVNKPYAITCSVVAFYFPFLLMVLAYYRIYVTAreharqirvlqragtp---------------------- 235
gi 11321563  178 nsnstYCVFmVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAkehahqiqmlqragas---------------------- 235
gi 432880360 163 gsnttSCVFmVNKPYALTCSLVAFYIPLVLMVLAYQRIYVTArahalqismlqraggagap------------------- 223
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                 #  ##  #                 #   #   #     
gi 12644029  236 -----sesrpqsadqhsthrmRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPfid---ytvPGQVWTAFLWLGYINSGL 307
gi 229294304 202 -----------ersmnnnenmRREKKAAKTLGIIMGCFLVCWMPFFVANIVEPlcgycitrsCDLCLKFFLWLGYINSTL 270
gi 483525120 228 -----adgrqhppdqhsthrmKTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPfin---ytvPGKLWTAFLWLGYINSGL 299
gi 47216965  249 yslrtaasssteqapmansrmRIETKAAKTLAVIMGCFCLCWAPFFITNVVDPfih---ysvPWQLWTTWLWLGYINSGL 325
gi 405972155 261 ----------svhckrrnskfKHETKAAKTIGIIMGCFCVCWFPFFIMNIIDPiig---hkiEYLPWTIALWLGYLNSML 327
gi 327420566 273 -------nhnhyshckrkskfKQESKAAKTLGIIMGCFSVCWFPFFITNVIDPlin---yriPYNPWQIALWLGYINSMM 342
gi 513206414 236 ------adsrhqpdqhsthrmKTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPfin---ytvPGKLWTAFLWLGYINSGL 306
gi 11321563  236 -----sesrpqsadqhsthrmRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPfid---ytvPGQVWTAFLWLGYINSGL 307
gi 432880360 224 ---gtsgvsadsadhqrnhrmRTETKAAKTLCIIMGCFCLCWAPFFVTNVVDPfid---yrvPDQLWTACLWLGYINSML 297
                        330
                 ....*....|....*.
Feature 1                        
gi 12644029  308 NPFLYAFLNksFRRAF 323
gi 229294304 271 NPMIYAFFNrsFRRAF 286
gi 483525120 300 NPFLYAFLNksFRRAF 315
gi 47216965  326 NPFLYAFLNraFRRAF 341
gi 405972155 328 NPFLYYNFNksFKTAF 343
gi 327420566 343 NPLLYYYFNrnFYHAF 358
gi 513206414 307 NPFLYAFLNksFRRAF 322
gi 11321563  308 NPFLYAFLNksFRRAF 323
gi 432880360 298 NPILYAFLNksFRRAF 313

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