Conserved Protein Domain Family
7tmA_D1-like_dopamine_R

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cd15057: 7tmA_D1-like_dopamine_R 
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.
Statistics
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PSSM-Id: 320185
View PSSM: cd15057
Aligned: 8 rows
Threshold Bit Score: 429.157
Threshold Setting Gi: 303324532
Created: 13-Nov-2008
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                     #  
gi 118228     24 ILTACFLSLLILSTLLGNTLVCAAVIRFRHlrsKVTNFFVISLAVSDLLVAVLVMPWKAVAEIa-gFWPFGs-FCNIWVA 101
gi 118214     41 VVTACLLTLLIIWTLLGNVLVCAAIVRSRHlraNMTNVFIVSLAVSDLFVALLVMPWKAVAEVa-gYWPFGa-FCDVWVA 118
gi 118200100  31 VGVGGTLYLIVLLTILGNLMVLTAVMKYPHlrsKVTNYFICSLAVSDLMVGFLVLPWAAAQELl-gYWPFGq-FCSTFVS 108
gi 291227895  72 IIIGLVLAFIVLFTVLGNALVILSVFVYRRlrtNITNWFIVSLAISDLLVAILVMSWAAVNLVa-gYWPFGe-FCQVHIT 149
gi 37499136   40 AILGLITVILILLTVIGNVLVILAVTCHRKm-rTVTNFLIVSLACADLSVGITVLPFAATNDIl-gYWPFGg-YCDVWVS 116
gi 303324532  25 IIIGIILYVIVVLAIGGNALVIASVLVFRKl-rTVTNYFIVSLAISDLLLALFVMDFNACFIVlgdYWPFGkvFCRFYIS 103
gi 217416485  10 ALTGCLLGALVLGTLAGNALVCLAVLRFRHlrtKVTNWFVLSLAISDLCVAILVMPWKAVTEVaggFWLFGsrFCDTWVA 89
gi 1706290    40 ALTGCVLCALIVSTLLGNTLVCAAVIKFRHlrsKVTNAFVVSLAVSDLFVAVLVMPWRAVSEVa-gVWLFGr-FCDTWVA 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         ##  ##                                                                         
gi 118228    102 FDIMCSTASILNLCVISVDRYWAISSPFRYERKMtPKAAFILISVAWTLSVLISFIPVQLSWHkakptspsdg------- 174
gi 118214    119 FDIMCSTASILNLCVISVDRYWAISRPFRYKRKMtQRMALVMVGLAWTLSILISFIPVQLNWHrdqaaswggldlpnnla 198
gi 118200100 109 LDVMCCTASILNLCVISVDRYWAISDPFKYERDMtCCRAAIMIGLAWCLSAMISLIPIGLGFHhigeti----------- 177
gi 291227895 150 LDIMLSTASILNLCVISVDRYWAVMKPFRYQAMMtRKRAVLMIIGVWILAALVSFIPVMTNAHraddvds---------- 219
gi 37499136  117 FDVLNSTASILNLVVIAFDRFLAITAPFTYHTRMtERTAGILIATVWGISLVMSFLPIQAGWYrdnlsaea--------- 187
gi 303324532 104 IDIMLSTASILNLCLISLDRYWAITSPFSYYQRVnATNAIILIVVVWVTSFLISVLPVMLGLHvdyslndee-------- 175
gi 217416485  90 FDIMCSTASILHLCIISLDRYWAIASPFRYERRMtQRLACAMIAMAWALSILISFVPVQLHWHkakdr------------ 157
gi 1706290   118 FDIMCSTASILNLCVISMDRYWAISNPFRYERRMtRRFAFLMIAVAWTLSVLISFIPVQLNWHradnns----------- 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                            #      #  ##  #                                             
gi 118228    175 -------natslaetidNCDSSlSRTYAISSSVISFYIPVAIMIVTYTRIYRIAqkqirriaaleraavhakncqtttgn 247
gi 118214    199 nwtpweedfwepdvnaeNCDSSlNRTYAISSSLISFYIPVAIMIVTYTRIYRIAqvqirrissleraaehaq-------s 271
gi 118200100 178 ------------tvtqrQCESNmNEIYAITSSFVSFYIPVIIMVLAYSKIMQIArrkyediaalhrsv------------ 233
gi 291227895 220 -----------lladppQCEFKlNGIYATVSSSISFYIPSTIILIIYYRIYQTArriekqikqqer-------------- 274
gi 37499136  188 ---------laiyadpcLCIFTaSTAYTIVSSLISFYIPLLIMLVFYGNIFKAArdqarkidalegri------------ 246
gi 303324532 176 --------fdffyteptFCVLIiNQWYALGSSVISFFIPIFIIGYTYARIFVVArrqarqiaaynntg------------ 235
gi 217416485 158 ------------rhpssSCDVSlNRTYAITSSLISFYIPVAIMIVTYTRIYRIAqaqirristleraggq---------- 215
gi 1706290   187 -----------saheqgDCNASlNRTYAISSSLISFYIPVLIMVGTYTRIFRIAqtqirrissleraagqraq------n 249
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                             #  ##  #                        #   #   #  
gi 118228    248 gkpvecsqpessfkmsfKRETKVLKTLSVIMGVFVCCWLPFFILNCILpfcgsge----tqpfciDSNTFDVFVWFGWAN 323
gi 118214    272 crssaacapdtslrasiKKETKVLKTLSVIMGVFVCCWLPFFILNCMVpfcsghpegppagfpcvSETTFDVFVWFGWAN 351
gi 118200100 234 ---nqntksvqesrtalRRETRIFKTLACILGVFIVCWLPFFILNCLLpfcplrtg-gkanftciDHTVFTVFEWLGWAN 309
gi 291227895 275 ------tlnikhkhsrsFGERKAIKTFGLIIGIFVICWLPFFVANCIIsfcd----------qcvPLDCYIAFTWLGWVN 338
gi 37499136  247 ----eqennrrgkkislAKEKKAAKTLGIIMGVFILCWLPFFVVNIVNpfcd----------rcvPDEVFIALTWLGWIN 312
gi 303324532 236 ---qriqgtdkkaqgsmRRERKATKTLAIIVGVFIGCWLPFFILNVVDpfcg----------rcvPPTLFSFTVWLGYVN 302
gi 217416485 216 -wpahskepastlrsslRKETKVLQTLSIIMGVFVCCWLPFFLLNCLLpfcqpesd-sngqspciDQTTFNVFVWFGWAN 293
gi 1706290   250 qshrasthdesalktsfKRETKVLKTLSVIMGVFVFCWLPFFVLNCVVpfcdvdk---vgeppcvSDTTFNIFVWFGWAN 326
                        330
                 ....*....|....*...
Feature 1                          
gi 118228    324 SSLNPIIYAFNAdFRKAF 341
gi 118214    352 SSLNPVIYAFNAdFQKVF 369
gi 118200100 310 SMLNPIIYAFNNdFRKAF 327
gi 291227895 339 STLNPVIYATNRdFRRAF 356
gi 37499136  313 SCFNPIIYAFNKeFRKVF 330
gi 303324532 303 SALNPIIYAQNRsFRNAF 320
gi 217416485 294 SSVNPVIYAFNAdFRRAF 311
gi 1706290   327 SSLNPVIYAFNAdFRKAF 344

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