Conserved Protein Domain Family
7tmA_alpha1_AR

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cd15062: 7tmA_alpha1_AR 
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.
Statistics
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PSSM-Id: 320190
View PSSM: cd15062
Aligned: 4 rows
Threshold Bit Score: 391.852
Threshold Setting Gi: 321453412
Created: 13-Nov-2008
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                   #   #
gi 116241241  46 ISVGLVLGAFILFAIVGNILVILSVACNRHlrtpTNYFIVNLAMADLLLSFTVLPFSAALEVlGYWVLGriFCDIWAAVD 125
gi 1168243    97 VGVGVFLAAFILMAVAGNLLVILSVACNRHlqtvTNYFIVNLAVADLLLSATVLPFSATMEVlGFWAFGraFCDVWAAVD 176
gi 1168246    27 ILLGVILGGLILFGVLGNILVILSVACHRHlhsvTHYYIVNLAVADLLLTSTVLPFSAIFEVlGYWAFGrvFCNIWAAVD 106
gi 321453412   3 LVVAVALSVIVLLTIGGNLLILAAVLFNSNlrgpTHILIANLAVADLLLGFLVLPFSATLEVtGNWYFGpiFCDVWAAVD 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  ##                                                                      #    
gi 116241241 126 VLCCTASILSLCAISIDRYIGVRYSLqYPTLVtRRKAILALLSVWVLSTVISIGPLLGWKEpa----pnDDKECGVteEP 201
gi 1168243   177 VLCCTASILSLCTISVDRYVGVRHSLkYPAIMtERKAAAILALLWVVALVVSVGPLLGWKEpv----ppDERFCGIteEA 252
gi 1168246   107 VLCCTASIMGLCIISIDRYIGVSYPLrYPTIVtQRRGLMALLCVWALSLVISIGPLFGWRQpa----peDETICQIneEP 182
gi 321453412  83 VLCCTASIMSLCVISVDRYIGVTRPLnYYSIVtAKRSTVLCLIVWISSLSISIGPLLGWKErmllldsaELQACNVnkEK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          #  ##  #                                                                      
gi 116241241 202 FYALFSSLGSFYIPLAVILVMYCRVYIVAkrttknleagvmkemsnskeltlrihs--------knfhedtlsstkakgh 273
gi 1168243   253 GYAVFSSVCSFYLPMAVIVVMYCRVYVVArsttrsleagvkrergkasevvlrihcr-----gaatgadgahgmrsakgh 327
gi 1168246   183 GYVLFSALGSFYLPLAIILVMYCRVYVVAkresrglksglktdksdseqvtlri-----------hrknapaggsgmasa 251
gi 321453412 163 AYVLFSTIGSFYLPTLIILAIYWRIYRTAvkqtkflesgtktdkstsslsgsevltlrvhvgranpmktvatttvghhhh 242
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                         #  ##  #               #   #   #               
gi 116241241 274 nprssiavklFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGslfstlkpPDAVFKVVFWLGYFNSCLNPIIYPCSSk 353
gi 1168243   328 tfrsslsvrlLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGslfpqlkpSEGVFKVIFWLGYFNSCVNPLIYPCSSr 407
gi 1168246   252 ktkthfsvrlLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGsffpdfkpSETVFKIVFWLGYLNSCINPIIYPCSSq 331
gi 321453412 243 hrptglsakmFKFRRQKKAAKTLGIVVGAFLLCWFPFFVILPVEalcstcniPSPLFSCCFWLGYCNSCLNPFIYASTSr 322

                 ....*.
Feature 1              
gi 116241241 354 EFKRAF 359
gi 1168243   408 EFKRAF 413
gi 1168246   332 EFKKAF 337
gi 321453412 323 EFKRAF 328

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