Conserved Protein Domain Family
7tmA_Peropsin

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cd15073: 7tmA_Peropsin 
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors
Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.
Statistics
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PSSM-Id: 320201
View PSSM: cd15073
Aligned: 9 rows
Threshold Bit Score: 408.356
Threshold Setting Gi: 405978352
Created: 10-Nov-2008
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 119331152  26 NIVAAYLITAGVISIFSNIVVLGIFVKYKEfrtaTNAIIINLAFTDIGVSGIGYPMSAASDLHg-----------sWKFG 94
gi 52219136   26 NIVAAYLITAGVISLSSNIVVLLMFVKFRElrtaTNAIIINLAFTDIGVAGIGYPMSAASDLHg-----------sWKFG 94
gi 3024312    26 NIVATYLIMAGMISIISNIIVLGIFIKYKElrtpTNAIIINLAVTDIGVSSIGYPMSAASDLYg-----------sWKFG 94
gi 30268589   37 LIVGLYLFVIGIIGTIENGITLATFSKFRSlrspTTMLLVHLAIADLGICIFGYPFSGASSLRs-----------hWLFG 105
gi 149638042  26 NIVAAYLITAGIMSIVSNVIVLGIFVKFEElrtaTNAIIINLAVTDIGVSGIGYPMSAASDLHg-----------sWKFG 94
gi 6677821    26 SVIAAYLIVAGITSILSNVVVLGIFIKYKElrtpTNAVIINLAFTDIGVSSIGYPMSAASDLHg-----------sWKFG 94
gi 229291185  36 LIVGLYLFVIGIIGTVENGITLATFTKFRSlrspTTMLLVHLAIADLGICIFGYPFSEILAYDvllclslvlhqshWLFG 115
gi 308210738  37 TIVGTYLIIIGILGTLGNGLVLVTFLRFRVlvtpTTLLLVNLAVSDLGLILFGFPFSASSSLSa-----------kWIFG 105
gi 405978352  16 RNFSGLSGKLGIFSLIGNGITIVVICRFPKlrtaANIFIANLAAADLAITILTFPFSVVSHFYn-----------gWQFG 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1              #   ##  ##                                                               #
gi 119331152  95 YtGCQIYAALNIFFGMASIGLLTVVAVDRYLTICRPdIGRRMtTRNYAALILAAWINAVFWASMPtVGWAGYASDPtgAT 174
gi 52219136   95 YmGCQIYAALNIFFGMASIGLLTVVAIDRYLTICRPdIGQKLtTRSYTLLIVAAWLNAVFWSSMPiVGWAGYAPDPtgAT 174
gi 3024312    95 YaGCQVYAGLNIFFGMASIGLLTVVAVDRYLTICLPdVGRRMtTNTYIGLILGAWINGLFWALMPiIGWASYAPDPtgAT 174
gi 30268589  106 GvGCQWYGFNGMFFGMANIGLLTCVAVDRYLVICRHdLVDKVnYNTYGVMAALGWLFAAFWAALPlVGWAEYALEPsgTA 185
gi 149638042  95 HaGCQIYAGLNIFFGMSSIGLLTVVAVDRYLTICRPaIGRKMtRSNYTAMILAAWMNGFFWASMPlLGWASYASDPtgAT 174
gi 6677821    95 HaGCQIYAGLNIFFGMVSIGLLTVVAMDRYLTISCPdVGRRMtTNTYLSMILGAWINGLFWALMPiIGWASYAPDPtgAT 174
gi 229291185 116 GvGCQWYGFNGMFFGMANIGLLTCVAVDRYLVICRQdLVDKVnYNTYGVMAALGWLFAAFWAALPlVGWAEYSLEPsgTA 195
gi 308210738 106 EgGCQWYAFMGFLFGSAHIGTLALLALDRYLIACRIsLRGKLtFKRYTQMITVVWTYAFFWALMPlLGWGRYGLEPsvTT 185
gi 405978352  85 QdVCRWYGFNCMLFGLGSIAFLAAISCDRYLVTCRHeLYCKFsKRHYFIVSVLLWTNCMIWAAAPfMGWGCYDNDVtgVL 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ###                ##   #                                                       
gi 119331152 175 CTANWRKNDv-pFVSYTMSVIAVNFVVPLTVMFYCYYNVSRTMkqytssnc------lesinmdWSDQVDVTKMSVVMIV 247
gi 52219136  175 CTINWRNNDt-sFVSYTMTVITVNFIIPLSVMFYCYYNVSATVkrfkasnc------ldsinmdWSDQMDVTKMSVIMIV 247
gi 3024312   175 CTINWRKNDr-sFVSYTMTVIAINFIVPLTVMFYCYYHVTLSIkhhttsdc------teslnrdWSDQIDVTKMSVIMIC 247
gi 30268589  186 CTINFQKNDs-lYISYVTSCFVLGFVVPLAVMAFCYWQASCFVskvlkgdiagdltfpvaanvdWEYQNHFSKMCLAMVA 264
gi 149638042 175 CTINWRKNDa-sFISYTMTVIAVNFAVPLIVMFYCYYNVSKAMrqypasrv------lenlnidWSEQVDVTKMSVVMIL 247
gi 6677821   175 CTINWRNNDt-sFVSYTMMVIVVNFIVPLTVMFYCYYHVSRSLrlyaasdc------tahlhrdWADQADVTKMSVIMIL 247
gi 229291185 196 CTINWQKNDs-lYISYVTSCFILGFALPLAVMMFCYWQASCFVnkvlkgdisgdltfpvavnvdWEYQNHFSKMCLAMVA 274
gi 308210738 186 CTIDWQHNDs-sYKSFLIVYFVLGFMVPFAIIAVSYIAIARRVgkksker--------pvvrdlWTNERSVTLMAFILIV 256
gi 405978352 165 CTITWTCNGraaFASFIYALSVVCFILPCCIITVSYRKTYQFIkavgagg--------sqenieWTHQKQITKMCVVAVI 236
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
Feature 1             #   #                      #   #                     
gi 119331152 248 MFLVAWSPYSIVCLWSSFgdpkkiSPAMAIIAPLFAKSSTFYNPCIYVIANkKFRRAI 305
gi 52219136  248 MFLAAWSPYSIVCLWASFgdpqkiPAPMAIIAPLLAKSSTFYNPCIYVIANkKFRRAI 305
gi 3024312   248 MFLVAWSPYSIVCLWASFgdpkkiPPPMAIIAPLFAKSSTFYNPCIYVVANkKFRRAM 305
gi 30268589  265 AFVVAWTPYSVLFLFAAFwnpadiPAWLTLLPPLIAKSSALYNPIIYIIANrRFRNAI 322
gi 149638042 248 MFLMAWSPYSIVCLWSSFgdpkkiSPAVAIMAPLFAKSSTFYNPCIYVVANkKFRRAM 305
gi 6677821   248 MFLLAWSPYSIVCLWACFgnpkkiPPSMAIIAPLFAKSSTFYNPCIYVAAHkKFRKAM 305
gi 229291185 275 AFVVAWTPYSVLFLFAAFgnpadiPAWITLLPPLIAKSSALYNPIIYIIANrRFRSAI 332
gi 308210738 257 TFFVAWSPYAVLCLWTIFaepntvPPFLTLIPPLFAKSSTVVNPLIYFLSNpKLRTAI 314
gi 405978352 237 LFLVAWMPFTIYFLIISIqeastlPALFHVVPAVFAKTSTCYNPVIYAIVNkRFRIAI 294

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