Conserved Protein Domain Family
7tmA_Opsin5_neuropsin

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cd15074: 7tmA_Opsin5_neuropsin 
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors
Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.
Statistics
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PSSM-Id: 320202
View PSSM: cd15074
Aligned: 21 rows
Threshold Bit Score: 332.317
Threshold Setting Gi: 443682495
Created: 10-Nov-2008
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 195539509  37 IIAGFYLTVIGILSTLGNGYVIFMSSKRKKkl--rpAEIMTVNLAVCDLGISVVGKPFSIISFFS-HRWIFGwm----gC 109
gi 229279429  39 IVIGVYLLLIGTGSILGNGRVLWLSYRNWAkl--rpVELFVVSLAVTDVGISVFGYPFAASSSLL-GRWSFGsa----gC 111
gi 3024255    20 RIIGIFISICCIIGVLGNLLIIIVFAKRRSvr--rpINFFVLNLAVSDLIVALLGYPMTAASAFS-NRWIFDni----gC 92
gi 115913856  34 IWAGVYLMFISLIAFIGNISVIVISLRKREkl--kpIDLLTINLAIADFLICVVSYPLPMISAFR-HRWSFGkf----gC 106
gi 115946480  72 LLTALYLTLVGIVSTIGNITVLCVLCRYGTfrk-rsVNILLMNMAVSDLGVSVAGYPLTAISGYR-GRWVFAdi----gC 145
gi 210103981 153 LAVAIYLTLLGIVAVGGNVMAIIVFVTEKEfrk-keHNSLLLNMALADLGVSIFGYPASTVSGYA-GRWVLGev----wC 226
gi 210123684  24 TIMGIYLTVVGLVSTVGNATVVLMFMLKWRqlcrkaPNLLIINLAAVDLCISVFGYPFSASSGFA-NQWLFSda----iC 98
gi 115946480 470 LHFPYDDTEGSSIATVGNITVICVLCRYRTfrk-rsINLLLINMAASDLGVSVAGYPLTTVSGYW-GRWLFGdv----gC 543
gi 125842309  22 TAIGVYLVILGWLSWIGNGTVILLLTKQRKal--epQDFLTLNLAISDASISIFGYSRGILEVFDvFRDEGYliktfwtC 99
gi 118722324  34 TIIGVYLLILGWLSWFGNSIVIFVLFRQRStl--qpTDYLTLNLAVSDASISVFGYSRGILEIFNiFKDSGYiissvwtC 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          #   ##  ##                                                                    
gi 195539509 110 RWYGWAGFFFGCGSLITMTAVSLDRYLKICHLaYGTWLkRHHAFICLALIWAYATFWATVPFAGVGSYAPEPf------g 183
gi 229279429 112 TWYGFTGFFFGLTSIANMALMSIMRFMIVYKGyPGPYPsRRATSALIAAAWLYGLFWACAPLAGWSQYHVEPf------g 185
gi 3024255    93 KIYAFLCFNSGVISIMTHAALSFCRYIIICQYgYRKKItQTTVLRTLFSIWSFAMFWTLSPLFGWSSYVIEVv------p 166
gi 115913856 107 VWYGFTSFLFAVGSMATLMVIALLRYAKLCREnVDQYQsRPFVIKVIVAIWGFAFFTTAPPLFGWSSYVPEPy------h 180
gi 115946480 146 QFSGFCVYALSCSTISTHAVVAIYRYIYIVKPyHRPRLsSSTSCLAILCIWTFTLFWTITPFFGWSSYTYEPf------g 219
gi 210103981 227 VIYAFVCYTFSMVTMNTLCAISIYRYIVMCTPqYAHLLtHRRTMYVILVTWLYALVFTVPPLVGVNYYTFEPireympgg 306
gi 210123684  99 TLYGFSCFLLSMVSMCTLCLISIHRYITICRPeHASKLtMTRTILAVVGAWVYGISVAVPPLFGIARYTYESf------g 172
gi 115946480 544 QFYAFCVYTLSCSTISTHAAIAVYRYIYIVKTdLRPKLtANFTSGVIVVIWVYAFFWTVTPFVGWSSYIYEPf------g 617
gi 125842309 100 KVDGFLILLFGLISINTLTAISVIRYIKGCHPhHAHHInKRNICLVITAVWLFCLFWAGAPLLGWGSYRARGy------- 172
gi 118722324 112 QVDGFFTLVFGLSSINTLTVISITRFIKGCHPhKAHCItNSTVAVCVVFIWIGAFFWSAAPVLGWGSYTDRGy------- 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         ####                 ##   #                                                    
gi 195539509 184 TSCTLDWwlaqasvaGQAFVLSILFFCLLFPTAVIVFSYVKIILKVksstkevah--------ydtriqnshILEMKLTK 255
gi 229279429 186 LSCTVDWgsfsrdagGMSFIICLLVFCVAIPVTAIMASYVAISAIYrqakksiaghl----qdnsamckkrnKLERSITL 261
gi 3024255   167 VSCSVNWygh--glgDVSYTISVIVAVYVFPLSIIVFSYGMILQEKvckdsrkngir----aqqrytprfiqDIEQRVTF 240
gi 115913856 181 LSCTIDFadt--spsGLSYTYFTTIVVFFMPLMIIVLCYVAIARKMihhnrrin----------vghnagrmLLEIRLLK 248
gi 115946480 220 TSCSINWygk--slgDLTYIICCVVFVFILPIIIMLYCYIGVAKKIkgidplrteerdi-avvfgrlrkhetKIDTRVTK 296
gi 210103981 307 IICSLNWnvr--ypgEMAYTVLTIFFGYVVYVVIMGYCYCKIYFKSknlkfgala--------sdkakkavkKDILKASL 376
gi 210123684 173 LSCTIDFhgt--tvaDMVYLSILIILCYVINVAVMGTCYFKIIRKFskhrfrevr---------dvrtshqhSFERGVTL 241
gi 115946480 618 TSCSVNWvgr--tisDISYMVACTIGVYLLQIFIMLYCYIRVAKKIrgvdpgrteekdagvvvfgrlrkreaKIDTHVTK 695
gi 125842309 173 GTCEIDWtralysipFKLYVIGIFFFNFFVPLFIIVFAYVSIIRTVnsshkssqg---------gdvserqkKIERSITR 243
gi 118722324 185 GTCEIDWvkanystiHKSYIISIFIFCFLVPVLLMLFCYISIINTVkrgnamnad---------gdlsdrqrKIERDVTI 255
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
Feature 1                    #   #                      #   #                     
gi 195539509 256 VAMLICAGFLIAWIPYAVVSVWSafgqpdsvPIQFSVVPTLLAKSAAMYNPIIYQVIDckFACCR 320
gi 229279429 262 MALAVCGGFLLAWLPYAVVGLWSavagvdavPLALASAAPLFAKSSSLWNPIIYLGMNdrFSAEL 326
gi 3024255   241 ISFLMMAAFMVAWTPYAIMSALAigs--fnvENSFAALPTLFAKASCAYNPFIYAFTNanFRDTV 303
gi 115913856 249 TACMITMAYTISWTPYAVIAMWVtyipvnqiPDAFRILPAFCAKTSSVYNPIIYCIFNksFRQDL 313
gi 115946480 297 ICFMMMASFIVVWTPYAVGSIWAski--gkiSASASVLPTMFAKSSCMINPIIFLTSSskFRADL 359
gi 210103981 377 MCMTMVVSFLIAWTPYAVSSTWDilte-edlPIIATILPSLFAKSSCMMNPIIYTCCNgkYRQAA 440
gi 210123684 242 RCILMTLFYLISWTPYTAVAVWTmvg--pppPVQLGMVAALTAKTHCAFNPILYMLMSevYRKLV 304
gi 115946480 696 MCFMMMLTFIVVWAPYAVECLRAahv--hriSALSSVLPTMFAKSSCMVNPIIFLTSSskFRQDL 758
gi 125842309 244 VSLILCAAFLLAWSPYAVISMWSalg--yqiPTLNGILASLFAKSASFYNPFIYIGMSskFRKDL 306
gi 118722324 256 VSIVICTAFILAWSPYAVVSMWSawg--fhvPNLTSIFTRLFAKSASFYNPLIYFGLSskFRKDV 318

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