Conserved Protein Domain Family
7tmA_Parapinopsin

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cd15075: 7tmA_Parapinopsin 
non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.
Statistics
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PSSM-Id: 320203
View PSSM: cd15075
Aligned: 6 rows
Threshold Bit Score: 466.947
Threshold Setting Gi: 52627178
Created: 10-Nov-2008
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                   #   #
gi 3024298    31 TILSIIMALSSTFGIILNMVVIIVTVRYKQlrqpLNYALVNLAVADLGCPVFGGLLTAVTNAMGYFSLGRvGCVLEGFAV 110
gi 47497974   31 TILALIMAVFCAAALFLNVTVIVVTFKYRQlrhpINYSLVNLAIADLGVTVLGGALTVETNAVGYFNLGRvGCVIEGFAV 110
gi 52627178   30 ITLSLLMAVFSITSVVLNATVIVVTLRHKQlrqpLNFALVNLAVADLGTTLTGSVPSVVTNAVGYYIMGRiGCVLEGFCV 109
gi 47229682   27 IVLSILMALVTGPAIVLNATVIIVSLMHKQlrqpLNYALVNMAAADLGTAVSGGLLSVVNNAQGHFSLGRtGCVLEGFAV 106
gi 45752399   24 TILAVIMAVFTIASLVLNSTVVIVTLRHRQlrhpLNFSLVNLAVADLGVTVFGASLVVETNAVGYFNLGRvGCVIEGFAV 103
gi 393716134  27 TIIAIIMATSCTLSVILNTTVIAVTIKYRQlrqpINYSLVNLAIADLGAALLGGSLNVETNAVGYYNLGRvGCVTEGFAM 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  ##                                                               ####        
gi 3024298   111 AFFGIAGLCSVAVIAVDRYMVVCRPlGAVMFqTKHALAGVVFSWVWSFIWNTPPlFGWGSYQLEGvmTSCAPNWyrrdpv 190
gi 47497974  111 AFFGIAALCTIAVIALDRVFVVCKPmGTLTFtPKQALAGIAASWIWSLIWNTPPlFGWGSYELEGvmTSCAPNWysadpv 190
gi 52627178  110 AFFGISALCTVALIAVERLFVVCRPlGSITFqCRHAAGGLLSCWLWSLIWNTPPlLGWGSYQLEGagTSCGPHWqsrelr 189
gi 47229682  107 SLCGIASLCTVALIAVERMFVICKPlGQMQFqKQHALAGISLSWLWSLTWNLPPlFGWGRYELEGvgTSCAPDWqsreph 186
gi 45752399  104 AFFGIAALCTIAVIAVDRFVVVCKPlGTLMFtRRHALLGIAWAWLWSFVWNTPPlFGWGSYELEGvrTSCAPDWysrdpa 183
gi 393716134 107 AFFGIVALCTIAVIAVDRAIVIAKPmGTLTFtTRKAMIGVAISWIWSLVWNTPPlFGWGGYQMEGvmTSCAPDWynsdpi 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1               ##   #                                                                   
gi 3024298   191 NVSYILCYFMLCFALPFATIIFSYMHLLHTLWQVaklqva--------------dsgstaKVEVQVARMVVIMVMAFLLT 256
gi 47497974  191 NMSYIVCYFSFCFAIPFLIIVGSYGYLMWTLRQVaklgva--------------eggttsKAEVQVSRMVIVMILAFLVC 256
gi 52627178  190 DVSYIICYFSVCFAVPFAIILVSYSWLLYTLRQVllemvnnlgtfgmlfsayydlghifkHYKHCNAALTLVLFFVVEYH 269
gi 47229682  187 NVSYVLAYFTVCFAAPFAIILVSYAKLMWTLHKVtkmtcl--------------eggavaKSEMKVAYMVVLMVATFLLS 252
gi 45752399  184 NVSYITSYFAFCFAIPFLVIVVAYGRLMWTLHQVaklgmg--------------esgstaKAEAQVSRMVVVMVVAFLVC 249
gi 393716134 187 NVSYIVCYFLFCFTIPFVTILVSYGYLLWTLRQVakfgvt--------------qrgstnKAEAQVSRMVIVMVMAFLIC 252
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
Feature 1        #   #                      #   #                     
gi 3024298   257 WLPYAAFALTVIidsniyiNPVIGTIPAYLAKSSTVFNPIIYIFMNrQFRDYA 309
gi 47497974  257 WLPYAAFAMTVVanpgmhiDPIIATVPMYLTKTSTVYNPIIYIFMNkQFQECV 309
gi 52627178  270 WLPYAALALTVVskpevqlAVLVKVLPIYMAKSSTVYNPLIYIYMNkQVSRTS 322
gi 47229682  253 WLPYAGLSMLVVfkpdveiNPLVGTVPVYLAKSSTAYNPIIYIYLNkQVNLPQ 305
gi 45752399  250 WLPYALFAMIVVtkpdvyiDPVIATLPMYLTKTSTVYNPIIYIFMNrQFRDCA 302
gi 393716134 253 WLPYATFALVVVgnpqiyiNPIIATVPMYMAKSSTFYNPIIYIFMNkQFRDCL 305

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