Conserved Protein Domain Family
7tmA_SWS2_opsin

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cd15077: 7tmA_SWS2_opsin 
short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes Short Wave-Sensitive opsin 2 (SWS2), which mediates visual transduction in response to light at short wavelengths (violet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.
Statistics
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PSSM-Id: 320205
View PSSM: cd15077
Aligned: 6 rows
Threshold Bit Score: 485.487
Threshold Setting Gi: 38231552
Created: 10-Nov-2008
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                   #   #
gi 147905103  47 MSISAFMLFTIIFGFPLNLLTIICTVKYKKlrshLNYILVNLAVANLIVICFGSTTAFYSFSQmYFSLGtlaCKIEGFTA 126
gi 129202     45 RAMAAFMFLLIALGVPINTLTIFCTARFRKlrshLNYILVNLALANLLVILVGSTTACYSFSQmYFALGptaCKIEGFAA 124
gi 189303851  47 LSLAAFMFLLVTLGFPINLLTVICTVRYKKlrshLNYILVNLAVSNMLVVCVGSATAFYSFAHmYFVLGptaCKIEGFAA 126
gi 21263842   45 MGMSAFMLFLFIAGTAINVLTIVCTIQYKKlrshLNYILVNLAISNLWVSVFGSSVAFYAFYKkYFVFGpigCKIEGFTS 124
gi 155008490  47 MVLSVFMFFLLITGIPINVLTIICTFKYKKlrshLNYILVNLAVANLIVVGFGSTTAFYSFSQmYFAWGplaCKIEGFAA 126
gi 38231552   47 YGMSAFMLFLVLAGFPLNFLTVFVTIKYKKlrshLNYILVNLAIANLIVVCCGSTLAFYSFMHkYFILGplfCKMEGFTA 126
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  ##                                                               ####        
gi 147905103 127 TLGGIIGLWSLAVVAFERFLVICKPmGNFTFrESHAVLGCILTWVIGLVAAIPPLLGWSRYIPEglQCSCGPDWYtvnNK 206
gi 129202    125 TLGGMVSLWSLAVVAFERFLVICKPlGNFTFrGSHAVLGCVATWVLGFVASAPPLFGWSRYIPEglQCSCGPDWYttdNK 204
gi 189303851 127 TLGGMVSLWSLAVIAFERFLVICKPlGNLSFrGTHAIFGCAATWVFGLAASLPPLFGWSRYIPEglQCSCGPDWYttnNK 206
gi 21263842  125 TIGGMVSLWSLAVVALERWLVICKPlGNFTFkTPHAIAGCILPWCMALAAGLPPLLGWSRYIPEglQCSCGPDWYttnNK 204
gi 155008490 127 TLGGMVSLWSLAVVAFERFLVICKPlGNFTFrSTHAIIGCVATWVFGLISSAPPLFGWSRYIPEglQCSCGPDWYttnNK 206
gi 38231552  127 TLGGMLSLWSLAVLAFERCLVICKPfGNIAFrGTHALIRCGFAWAAAIAASTPPLFGWSRYIPEglQCSCGPDWYttnNK 206
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                 ##   #                                                    #   #        
gi 147905103 207 WNNESYVLFLFCFCFGFPLAIIVFSYGRLLLALhavakqqeqsatTQKAEREVTRMVIVMVVGFLVCWLPYASFALWAVt 286
gi 129202    205 WHNESYVLFLFTFCFGVPLAIIVFSYGRLLITLravarqqeqsatTQKADREVTKMVVVMVLGFLVCWAPYTAFALWVVt 284
gi 189303851 207 WNNESYVIFLFSFCFGVPLSIIIFSYGRLLLTLrsvakqqeqsatTQKAEREVTKMVIVMVLGFLVCWLPYASFSLWVVt 286
gi 21263842  205 FNNESYVMFLFCFCFAVPFSTIVFCYGQLLITLklaakaqadsasTQKAEREVTKMVVVMVFGFLICWGPYAIFAIWVVs 284
gi 155008490 207 WNNESYVIFLFCFCFGFPLSVIIFSYGRLLMTLravakqqeqsasTQKAEREVTKMVVVMVLGFLVCWLPYTVFSLWVVt 286
gi 38231552  207 YNNESYVMFLFIFCFGTPFTIIIVSYSKLILTLraaaaqqqesasTQKAEKEVSRMVVIMVGGFLVCWLPYASLALWIVf 286
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
Feature 1                      #   #                     
gi 147905103 287 hrgelFDLRMSSVPSVFSKASTVYNPFIYIFMNrQFRSCM 326
gi 129202    285 hrgrsFEVGLASIPSVFSKSSTVYNPVIYVLMNkQFRSCM 324
gi 189303851 287 nrgqaFDLRMASIPSVFSKASTVYNPVIYVFMNkQFRSCM 326
gi 21263842  285 nrgapFDLRLATIPSCLCKASTVYNPVIYVLMNkQFRSCM 324
gi 155008490 287 hrgesFELALGSIPAVFSKSSTVYNPLIYVFMNkQFRSCM 326
gi 38231552  287 nrgspFDLRLATIPSVFSKASTVYNPVIYIFLNkQFRSCM 326

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