Conserved Protein Domain Family
7tmA_Encephalopsin

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cd15078: 7tmA_Encephalopsin 
encephalopsins (opsin-3), member of the class A family of seven-transmembrane G protein-coupled receptors
Encephalopsin, also called Opsin-3 or Panopsin, is a mammalian extra-retinal opsin that is highly localized in the brain. It is thought to play a role in encephalic photoreception. Encephalopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.
Statistics
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PSSM-Id: 320206
View PSSM: cd15078
Aligned: 4 rows
Threshold Bit Score: 440.42
Threshold Setting Gi: 512818095
Created: 10-Nov-2008
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                   #   #
gi 17380172   42 ERLALLLGSIGLLGVGNNLLVLVLYYKFQRLRTPTHLLLVNISLSDLLVSLFGVTFTFVSCLRNGWVWDtvgCVWDGFSG 121
gi 118088156  35 ELLALLIATIGTLGVCNNLLVLVLYYKFKRLRTPTNLFLVNISLSDLLVSVCGVSLTFMSCLRSRWVWDaagCVWDGFSN 114
gi 162287347  26 KLLTFTIGSIGVLGFCNNIIVIILYSRYKRLRTPTNLLIVNISVSDLLVSLTGVNFTFVSCVKRRWVFNsatCVWDGFSN 105
gi 512818095   8 HFLALIVATVGFLGLVNNLLVLILYCKFKRLQTPTNLLFFNTSLCHFVFSLLAITFTFMSCVRGSWAFSvemCVFHGFSK 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  ##                                                            ####           
gi 17380172  122 SLFGIVSIATLTVLAYERYIRVVHARVinFSWAWRAITYIWLYSLAWAGAPLLGWNRYILDvhgLGCTVDWkskDANDSS 201
gi 118088156 115 SLFGIVSIMTLTVLAYERYIRVVHAKVidFSWSWRAITYIWLYSLAWTGAPLLGWNRYTLEihgLGCSMDWkskDPNDTS 194
gi 162287347 106 SLFGIVSIMTLSGLAYERYIRVVHAKVvdFPWAWRAITHIWLYSLAWTGAPLLGWNRYTLEvhqLGCSLDWaskDPNDAS 185
gi 512818095  88 NLLGIVSFGTLTVVAYERYARVVYGKYvnSSWSKRSITFVWVYSLAWTGFPLIGWNLYTFEthkLDCSFEWtatDPKDTA 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1            ##   #                                                        #   #         
gi 17380172  202 FVLFLFLGCLVVPLGVIAHCYGHILYSIRMLRcvedlqtiqviKILKYEKKLAKMCFLMIFTFLVCWMPYIVICFLVVNG 281
gi 118088156 195 FVLLFFLGCLVAPVVIMAYCYGHILYAVRMLRcvedfqtsqviKLLKYEKKVAKMCFLMISTFLICWMPYAVVSLLVTYG 274
gi 162287347 186 FILFFLLGCFFVPVGVMVYCYGNILYTVKMLRsiqdlqtvqtiKILRYEKKVAVMFLMMISCFLVCWTPYAVVSMLEAFG 265
gi 512818095 168 FVLLFFLACITLPLSIMAYCYGYILYEIQKLRsvkniqnfqeiTILDYEIKMAKMCLLMMLTFLIGWMPYTILSLLVTSG 247
                        250       260       270
                 ....*....|....*....|....*....|....*....
Feature 1                     #   #                     
gi 17380172  282 hghlvTPTISIVSYLFAKSNTVYNPVIYVFMIRKFRRSL 320
gi 118088156 275 ysnlvTPTVAIIPSFFAKSSTAYNPVIYIFMSRKFRQCL 313
gi 162287347 266 kksvvSPTVAIIPSLFAKSSTAYNPVIYAFMSRKFRRCM 304
gi 512818095 248 yskfiTPTITVMPSLLAIASAAYNPVIHIFTIKKFRQCL 286

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