Conserved Protein Domain Family
7tmA_LWS_opsin

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cd15081: 7tmA_LWS_opsin 
long wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors
Long Wave-Sensitive opsin is also called red-sensitive opsin or red cone photoreceptor pigment, which mediates visual transduction in response to light at long wavelengths. Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.
Statistics
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PSSM-Id: 320209
View PSSM: cd15081
Aligned: 6 rows
Threshold Bit Score: 579.17
Threshold Setting Gi: 60392868
Created: 10-Nov-2008
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 129218     39 GPNYHIAPRWVYNLTSVWMIFVVAASVFTNGLVLVATWKFKKlrhpLNWILVNLAVADLGETVIASTISVINQISGYFIL 118
gi 129219     42 GPNYHIAPRWVYHLTSVWMIFVVTASVFTNGLVLAATMKFKKlrhpLNWILVNLAVADLAETVIASTISIVNQVSGYFVL 121
gi 60392868   38 GPNYHIAPRWVYNVATVWMFFVVVASTFTNGLVLVATAKFKKlrhpLNWILVNLAIADLGETLFASTISVINQVFGYFIL 117
gi 3024311    41 GPNYHIAPRWVYNLTSIWMIFVVFASVFTNGLVIVATLKFKKlrhpLNWILVNMAIADLGETVIASTISVFNQIFGYFIL 120
gi 38231550   40 GPNYHIAPRWMYNLTSFWMIIVVILSLFTNGLVLVATLKFKKlrhpLNWILVNLAIADIGETIFASTVSVVNQIFGYFIL 119
gi 155008486  40 GPNYHIAPRWVYNLTSLWMIFVVFASCFTNGLVLMATYKFKKlrhpLNWILVNLAIADLGETLIASTISVTNQIFGYFIL 119
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1               #   ##  ##                                                               
gi 129218    119 GhpmCVVEGYTVSACGITALWSLAIISWERWFVVCKPfGNIKFdGKLAVAGILFSWLWSCAWTAPPIFGWSRYWPHGLKT 198
gi 129219    122 GhpmCVLEGYTVSLCGITGLWSLAIISWERWLVVCKPfGNVRFdAKLAIVGIAFSWIWSAVWTAPPIFGWSRYWPHGLKT 201
gi 60392868  118 GhpmCIFEGYTVSVCGIAGLWSLTVISWERWVVVCKPfGNVKFdGKWASAGIIFSWVWAAVWCAPPIFGWSRYWPHGLKT 197
gi 3024311   121 GhpmCVLEGFTVSTCGITALWSLTVIAWERWFVVCKPfGNIKFdEKLAATGIIFSWVWSAGWCAPPMFGWSRFWPHGLKT 200
gi 38231550  120 GhplCVFEGFTVSVCGITALWSLAIISFERWMVVCKPfGNLKFdGKVAIVLIIFSWAWSAGWCAPPIFGWSRYWPHGLKT 199
gi 155008486 120 GhpmCMLEGFTVATCGITGLWSLTIIAWERWVVVCKPfGNIKFdGKWAAGGIIFSWVWSAFWCAMPLFGWSRFWPHGLKT 199
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ####                 ##   #                                                    #
gi 129218    199 SCGPDVfsgssdpGVQSYMVVLMVTCCFFPLAIIILCYLQVWLAIravaaQQKESESTQKAEKEVSRMVVVMIVAYCFCW 278
gi 129219    202 SCGPDVfsgssypGVQSYMIVLMVTCCIIPLAIIMLCYLQVWLAIravakQQKESESTQKAEKEVTRMVVVMIFAYCVCW 281
gi 60392868  198 SCGPDVfggnedpGVQSYMLVLMITCCILPLAIIILCYIAVFLAIhavaqQQKDSESTQKAEKEVSRMVVVMILAFCLCW 277
gi 3024311   201 SCGPDVfsgssdpGVQSYMLVLMITCCIIPLAIIILCYLHVWWTIrqvaqQQKESESTQKAEREVSRMVVVMIVAYIFCW 280
gi 38231550  200 SCGPDVfsgstdpGVQSYMVVLMITCCFIPLALIIICYLQVWLAIhtvaqQQKESETTQKAERDVSRMVVVMIFAYIFCW 279
gi 155008486 200 SCGPDVfsgedkyGTRSFMIALMITCCIIPLGVIILCYIQVWWAIrtvakQQKESESTQKAEKEVSRMVVVMIFAYCFCW 279
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
Feature 1           #                      #   #                     
gi 129218    279 GPYTFFACFAaanpgyaFHPLAAALPAYFAKSATIYNPIIYVFMNrQFRNCI 330
gi 129219    282 GPYTFFACFAaanpgyaFHPLMAALPAYFAKSATIYNPVIYVFMNrQFRNCI 333
gi 60392868  278 GPYTAFACFAaanpgyaFHPLAAAMPAYFAKSATIYNPIIYVFMNrQFRVCI 329
gi 3024311   281 GPYTFFACFAafspgysFHPLAAALPAYFAKSATIYNPIIYVFMNrQFRNCI 332
gi 38231550  280 GPYTFFACFAaanpgyaFHPLAAALPAYFAKSATIYNPIIYVFMNrQFRNCI 331
gi 155008486 280 GPYTFMACFGaaypgyaFHPLAAALPAYFAKSATIYNPIIYVFMNrQFRNCI 331

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